150438-02-1
Chemical Structure
CI-996
- CAS No.: 150438-02-1
- Formula:C27H22F3N7O3
- Molecular Weight:549.50
IUPAC Name: 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-propyl-4-(2-(2,2,2-trifluoroacetyl)-1H-pyrrol-1-yl)-1H-imidazole-5-carboxylic acid
InChIKey: MGSBGAVGFLLRDU-UHFFFAOYSA-N
SMILES: O=C(C1=C(N2C(C(C(F)(F)F)=O)=CC=C2)N=C(CCC)N1CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3)O
Biological Activity: CI-996 is a potent, selective, orally active angiotensin II (Ang II) type 1 (AT1) receptor antagonist. In rat liver membranes CI-996 displaces specifically bind [125I]Ang II with an IC50 of 0.8 nM. CI-996 has blood pressure-lowering activity[1].
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CI-996 | CI-996 is a potent, selective, orally active angiotensin II (Ang II) type 1 (AT1) receptor antagonist. In rat liver membranes CI-996 displaces specifically bind [125I]Ang II with an IC50 of 0.8 nM. CI-996 has blood pressure-lowering activity. | |||||||||||||||||||||
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Keywords
