CHI3L1 Protein, Mouse (360a.a, HEK293, His)

CHI3L1 Protein, a carbohydrate-binding lectin with a preference for chitin, participates in tissue remodeling and cellular adaptation to environmental changes. It is involved in Th2 inflammation, IL-13-induced inflammation, allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation, M2 macrophage differentiation, and pathogenic enteric bacteria invasion. In colonic epithelial cells, it activates the AKT1 signaling pathway, leading to IL8 production. It also enhances antibacterial responses in the lung and regulates hyperoxia-induced injury and inflammation. CHI3L1 exists as a monomer. CHI3L1 Protein, Mouse (360a.a, HEK293, His) is the recombinant mouse-derived CHI3L1 protein, expressed by HEK293 , with C-His labeled tag. The total length of CHI3L1 Protein, Mouse (360a.a, HEK293, His) is 360 a.a., with molecular weight of 42-50 kDa.

CHI3L1 Protein is a carbohydrate-binding lectin that exhibits a specific preference for chitin. Although it lacks chitinase activity, it plays crucial roles in tissue remodeling and enables cells to adapt and respond to environmental changes. It is involved in various processes, such as T-helper cell type 2 (Th2) inflammatory response, IL-13-induced inflammation, regulation of allergen sensitization, modulation of inflammatory cell apoptosis, dendritic cell accumulation, and promotion of M2 macrophage differentiation. Furthermore, it facilitates the invasion of pathogenic enteric bacteria into the colonic mucosa and lymphoid organs. In colonic epithelial cells, it mediates the activation of the AKT1 signaling pathway, leading to subsequent production of IL8. CHI3L1 also regulates antibacterial responses in the lung by enhancing macrophage bacterial killing, controlling bacterial dissemination, and promoting host tolerance. Additionally, it plays a role in regulating hyperoxia-induced injury, inflammation, and epithelial apoptosis in the lung. It exists as a monomer.

Mouse

HEK293

C-His

Q61362 (Y30-A389)

12654  [NCBI]

42-50 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.