NOX4 Protein, Pongo abelii (Cell-Free, His)

NOX4 protein generates intracellular superoxide by forming a complex with CYBA/p22phox. NOX4 Protein, Pongo abelii (Cell-Free, His) is the recombinant NOX4 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of NOX4 Protein, Pongo abelii (Cell-Free, His) is 578 a.a., with molecular weight of 69.7 kDa.

NOX4 protein, a constitutive NADPH oxidase, functions as an intracellular superoxide generator upon complex formation with CYBA/p22phox. This enzyme plays a pivotal role in regulating signaling cascades, potentially through the inhibition of phosphatases. Additionally, NOX4 may act as an oxygen sensor, modulating the KCNK3/TASK-1 potassium channel and HIF1A activity. It is implicated in the regulation of insulin signaling cascades and may contribute to apoptosis, bone resorption, and lipolysaccharide-mediated activation of NFKB. Activated by insulin and inhibited by diphenylene iodonium, NOX4 is also responsive to plumbagin and can be activated by phorbol 12-myristate 13-acetate (PMA). These diverse regulatory functions highlight the versatile role of NOX4 in cellular processes and signaling pathways.

Others

E. coli Cell-free

N-10*His

Q5R5C5 (M1-S578)

100171782

MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHVAAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTYAIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLPEYFSEHFHEPFPEGFSKPEEFTQNTFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVISHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGKTVGVFCCGPNSLSKTLHKLSNQINSYGTRFEYNKESFS

69.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.