1. Recombinant Proteins
  2. Recombinant Mouse Interleukin-1 beta

Recombinant Mouse Interleukin-1 beta

Cat. No.: HY-P7073
Handling Instructions

Recombinant Mouse Interleukin-1 beta is a proinflammatory, cell-associated cytokine, produced by monocytes, tissue macrophages, keratinocytes and other epithelial cells.

For research use only. We do not sell to patients.

Protein Expression Service

Recombinant Proteins-MedChemExpress
Size Price Stock Quantity
10 μg $220 In-stock
Estimated Time of Arrival: December 31
50 μg $560 In-stock
Estimated Time of Arrival: December 31
100 μg   Get quote  
250 μg   Get quote  

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  • Technical Parameters

  • Properties

  • Documentation

rMuIL-1β; Catabolin; IL1F2; IL-1 beta; IL1B



E. coli



Gene ID


Molecular Weight

Approximately 17.5 kDa

AA Sequence


Biological Activity
The ED50 is <2.0 pg/mL as measured by mouse D10S cells, corresponding to a specific activity of >5.0 × 108 units/mg.

Lyophilized powder.


Lyophilized after extensive dialysis against PBS.

Endotoxin Level

<0.2 EU/μg, determined by LAL method.


Reconstitute the lyophilized recombinant Murine Interleukin-1 beta (rMuIL-1β) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability

Lyophilized recombinant Murine Interleukin-1 beta (rMuIL-1β) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.


Room temperature in continental US; may vary elsewhere.


IL-1β is a potent proinflammatory cytokine, whose levels are increased in patients with alcoholic liver disease (ALD). IL-1β is produced as inactive pro–IL-1β (encoded by pro-Il-1b) in response to inflammatory stimuli, including both microbial products and endogenous danger-associated molecules. IL-1β gene expression and synthesis of pro-IL-1β occurs after activation of pattern recognition receptors (PRRs). Inflammatory stimuli also drive activation of cytosolic CARD and PYHIN domain-containing PRRs that recruit ASC and caspase-1 (Casp-1) to assemble into the multiprotein complex inflammasome. Pro-Casp-1 (encoded by pro-Casp-1), activated by the inflammasome, cleaves pro–IL-1β into the bioactive IL-1β. IL-1β acts in an autocrine/paracrine manner via the type I IL-1 receptor (IL-1R1). Activation of IL-1R1 is inhibited by its binding to the IL-1 receptor antagonist (IL-1Ra), a naturally occurring cytokine whose function is to prevent the biologic response to IL-1. Treatment with IL-1Ra significantly improves symptoms in patients with rheumatoid arthritis or autoinflammatory syndromes; unlike anti-TNF therapy, it is not associated with infectious complications[1].

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Recombinant Mouse Interleukin-1 beta
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