1. Search Result
Search Result
Targets Recommended: CRISPR/Cas9
Results for "

1226443-41-9

" in MCE Product Catalog:
Cat. No. Product Name Target Research Areas
  • HY-144981
    HQ461

    CDK Molecular Glues Cancer
    HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.