1. Cell Cycle/DNA Damage
    PROTAC
  2. CDK
    Molecular Glues
  3. HQ461

HQ461 

Cat. No.: HY-144981
Handling Instructions

HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.

For research use only. We do not sell to patients.

HQ461 Chemical Structure

HQ461 Chemical Structure

CAS No. : 1226443-41-9

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Description

HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death[1].

Molecular Weight

345.44

Formula

C15H15N5OS2

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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HQ461
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