1226443-41-9
1226443-41-9
Chemical Structure
HQ461
- CAS 番号: 1226443-41-9
- Formula:C15H15N5OS2
- Molecular Weight:345.44
IUPAC Name: 2-(2-((6-methylpyridin-2-yl)amino)thiazol-4-yl)-N-(5-methylthiazol-2-yl)acetamide
InChIKey: QMRBCNQCRMTXBE-UHFFFAOYSA-N
SMILES: O=C(NC1=NC=C(C)S1)CC2=CSC(NC3=NC(C)=CC=C3)=N2
Biological Activity: HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death[1].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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HQ461 | 98.10% | HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.89
HY-148523HQ005 -
Similarity Score 0.60
HY-148133GSK-3β inhibitor 12 -
Similarity Score 0.59
HY-179289ZLY025 -
Similarity Score 0.58
HY-175916LCK ligand-1 -
Similarity Score 0.57
HY-103482RJNJ0966 (Standard) -
Similarity Score 0.56
HY-13257Thiazovivin -
Similarity Score 0.56
HY-108348RBML-259 (Standard) -
Similarity Score 0.55
HY-16689VU 0240551 -
Similarity Score 0.55
HY-171955LXG6403 -
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