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" in MCE Product Catalog:
Cat. No. Product Name Target Research Areas
  • HY-123714

    MAP4K Apoptosis Cancer Inflammation/Immunology
    TL4-12 is a selective MAP4K2/GCK inhibitor, dose-dependently downregulates IKZF1 and BCL-6 and leads to MM cell proliferation inhibition (IC50=37 nM) accompanied by induction of apoptosis. TL4-12 can be used to overcome immunomodulatory drug resistance in multiple myeloma (MM).