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" in MCE Product Catalog:
Cat. No. Product Name Target Research Areas
  • HY-146105
    Anticancer agent 65

    Apoptosis MDM-2/p53 ROS Kinase MMP Bcl-2 Family Cancer
    Anticancer agent 65 (compound 4c) shows excellent activity in cancer cell lines, especially A549 cells, with an IC50 of 1.07 μM. Anticancer agent 65 induces S-phase arrest in A549 cells and increases the expression level of p53 and p21. Anticancer agent 65 causes apoptosis, ROS generation and collapse of MMP in A549 cells.