Search Result
Results for "
4-1BB L Inhibitors
" in MedChemExpress (MCE) Product Catalog:
3002
Inhibitors & Agonists
253
Biochemical Assay Reagents
551
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-P99572
-
|
BNT-312; DuoBody-CD40x-4-1BB; GEN1042
|
TNF Receptor
|
Inflammation/Immunology
Cancer
|
|
Tecaginlimab (BNT-312) is a Fc-inert bispecific antibody for dual targeting and conditional stimulation of CD40 and 4-1BB. Tecaginlimab can enhance priming and reactivation of tumor-specific immunity .
|
-
-
- HY-P99119
-
|
|
TNF Receptor
|
Inflammation/Immunology
|
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Anti-Mouse 4-1BB/CD137 Antibody (3H3) is an IgG2a antibody agonist against mouse 4-1BB, derived from a rat host, capable of stimulating 4-1BB signaling in vivo.
|
-
-
- HY-P99605
-
|
PRS 343
|
EGFR
TNF Receptor
|
Cancer
|
|
Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (Kd=0.3 nM) and human monomeric CD137 (4-1BB; Kd=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research .
|
-
-
- HY-P99419
-
|
GEN1046
|
PD-1/PD-L1
|
Cancer
|
|
Acasunlimab (GEN1046) is a bispecific antibody (bsAb) targeting PD-L1 and 4-1BB. Acasunlimab enhances T-cell and NK-cell function through conditional 4-1BB stimulation while constitutively blocking the PD-1/PD-L1 inhibitory axis. Acasunlimab can be used in research of cancer .
|
-
-
- HY-P990067
-
|
ATOR-1017
|
TNF Receptor
|
Cancer
|
|
Evunzekibart (ATOR-1017) is an Fc-γ receptor conditional 4-1BB agonist and IgG4-type antibody. Evunzekibart can be used as monotherapy or in combination with anti-PD1 to exert anticancer activity.
|
-
-
- HY-P1170
-
|
Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH
|
Opioid Receptor
|
Neurological Disease
|
|
N-terminally acetylated Leu-enkephalin is the N-terminally acetylated form of Leu-enkephalin. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.
|
-
-
- HY-121834
-
-
-
- HY-P990017
-
|
CD19-4-1BBL; RO7227166; RG6076
|
CD19
|
Cancer
|
|
Englumafusp alfa (CD19-4-1BBL; RO7227166) is a fusion construct comprised of a CD19-specific antibody domain fused to a trimerized extracellular domains of human 41BBL. Englumafusp alfa promotes CD19-specific 4-1BB cross-linking on the surface of T and NK cells .
|
-
-
- HY-P990809
-
|
|
TNF Receptor
|
Others
|
|
Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) is a kind of rat IgG1 kappa in vivo mouse antibody, targeting to 4-1BB/CD137. The recommend isotype control of Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3): Rat IgG1 kappa, Isotype Control (HY-P99979).
|
-
-
- HY-P99119A
-
|
|
Transmembrane Glycoprotein
|
Others
|
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Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3) is a mouse-derived IgG2a, κ type antibody agonist, targeting to mouse 4-1BB/CD137.
|
-
-
- HY-137392
-
|
1-Naphthalenesulfonyl-Ile-Trp-CHO
|
Cathepsin
|
Others
|
|
Cathepsin L-IN-4 is an inhibitor of cathepsin L with IC50 at nanomolar concentrations .
|
-
-
- HY-163389
-
|
|
SARS-CoV
Cathepsin
|
Infection
|
|
Mpro/Cathepsin L-IN-1 (Compound 4d) is a SARS-CoV-2 M pro/hCatL inhibitor, with Kis of 5.54 μM and 0.701 μM respectively .
|
-
-
- HY-169171
-
|
|
Cathepsin
|
Infection
|
|
Cathepsin L-IN-5 (D6-3) is a potent Cathepsin L (CatL) inhibitor with an IC50 of 0.27 nM. Cathepsin L-IN-5 effectively blocks the CatL function and substantially hinders the entry of the SARS-CoV-2 pseudovirus to cells by inhibiting the cleavage of the spike protein. Cathepsin L-IN-5 can be utilized in SARS-CoV-2 research .
|
-
-
- HY-145729
-
|
AZD9150
|
STAT
Apoptosis
|
Cancer
|
|
Danvatirsen is an antisense oligonucleotide targeting STAT3 with potential antitumor activity. Danvatirsen binds to STAT3 mRNA, thereby inhibiting translation of the transcript. Suppression of STAT3 expression induces tumor cell apoptosis and decreases tumor cell growth.
|
-
-
- HY-147252
-
-
-
- HY-132600
-
|
Temavirsen
|
MicroRNA
HCV
|
Infection
|
|
RG-101 is a hepatocyte targeted N-acetylgalactosamine conjugated oligonucleotide that antagonises miR-122. miR-122 is an important host factor for hepatitis C virus (HCV) replication .
|
-
-
- HY-145725A
-
|
ISIS 598769; IONIS 598769; BIIB 065; ISIS-DMPK-2.5Rx
|
Ser/Thr Kinase
|
Others
|
|
Baliforsen is an antisense oligonucleotide (16 nucleotides) designed to target myotonic dystrophy protein kinase (DMPK) mRNA and research myotonic dystrophy.
|
-
-
- HY-147406
-
-
-
- HY-P99056
-
|
PF 05082566
|
TNF Receptor
|
Inflammation/Immunology
Cancer
|
|
Utomilumab (PF 05082566) is a fully human IgG2 mAb agonist of the T-cell costimulatory receptor 4-1BB/CD137. Utomilumab can be used for the research of relapsed/refractory follicular lymphoma (FL) and other CD20 + non-Hodgkin lymphomas (NHL) .
|
-
-
- HY-P1332
-
|
[D-Ser2, Leu5, Thr6]-enkephalin
|
Opioid Receptor
|
Neurological Disease
|
|
DSLET ([D-Ser2, Leu5, Thr6]-enkephalin) is a highly specific agonist of the δ-receptor. DSLET is an enkephalin-related peptide selectively bound to the δ opioid receptor .
|
-
-
- HY-131923
-
|
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Notch
|
Cancer
|
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DAPM is a Notch pathway inhibitor with anticancer activity and antiproliferative effects. DAPM effectively inhibits tubular adenoma development by inhibiting cell proliferation and inducing the expression of Krüppel-like factor 4 (KLF4) and p21 in human colon cancer cells .
|
-
-
- HY-P5367
-
|
PMDM6-F
|
Fluorescent Dye
|
Others
|
|
5-FAM-PMDM6 (PMDM6-F) is a biological active peptide. (PMDM6-F is a fluorescent-labeled probe for MDM2-binding assay.)
|
-
-
- HY-N12730
-
|
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Others
|
Others
|
|
Euphoscopin B (compound 5) is a cytotoxic macrocyclic diterpene isolated from Euphorbia helioscopia L .
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-
-
- HY-N12731
-
|
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Others
|
Others
|
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Epieuphoscopin B (compound 3) is a cytotoxic macrocyclic diterpene isolated from Euphorbia helioscopia L .
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-
-
- HY-N7649
-
|
|
Others
|
Others
|
|
Rhombifoline is an alkaloid isolated for the first time from the leaves and stems of A. foetida L. .
|
-
-
- HY-115387
-
-
-
- HY-P4306
-
-
-
- HY-N1668
-
|
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Others
|
Others
|
|
2,4-Dihydroxyphenylacetic acid (compound 3) is a natural product that can be obtained from Nigella damascene L. seeds .
|
-
-
- HY-N9260
-
|
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Others
|
Inflammation/Immunology
|
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4E-Deacetylchromolaenide 4'-O-acetate (Compound 11) is a sesquiterpenoid that can be isolated fromEupatorium chinense L. .
|
-
-
- HY-149587
-
|
R-(-)-Callosobruchusic acid
|
Insecticide
|
Others
|
|
Callosobruchusic acid (R-(-)-Callosobruchusic acid) is an active compound in sex pheromone of the bean pest Callosobruchus chinensis L. Callosobruchusic acid can be used in pest control strategy development .
|
-
-
- HY-129568
-
|
|
Others
|
Others
|
|
Tetraphyllicine is an alkaloid, which can be isolated from Rauwolfia tetraphylla L. Tetraphyllicine can be used in research about the biosynthetic relationship of indole and indoline alkaloids .
|
-
-
- HY-P0014
-
-
-
- HY-P0014A
-
|
|
GLP Receptor
|
Metabolic Disease
|
|
Liraglutide acetate is the acetate form of Liraglutide (HY-P0014), a glucagon-like peptide-1 (GLP-1) receptor agonist studied in type 2 diabetes .
|
-
-
- HY-P0014S2
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Liraglutide- 13C6, 15N (TFA)is the 13C and 15N labeledLiraglutide(HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus .
|
-
-
- HY-P0014S
-
-
-
- HY-P0014S1
-
|
|
Isotope-Labeled Compounds
GLP Receptor
GCGR
|
Others
|
|
Liraglutide- 13C5, 15N (tetraTFA) is the 13C and 15N labeled Liraglutide (HY-P0014) . Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus .
|
-
-
- HY-N11823
-
-
-
- HY-116139
-
|
Merlin; RP-201772
|
Herbicide
|
Infection
|
|
Isoxaflutole (Merlin; RP-201772) is a selective herbicide for pre-emergence control of a wide range of important broadleaf and grass weeds in corn and sugarcane. Isoxaflutole is a precursor and delivery vector of diketonitrile (DKN), which is an inhibitor for 4-hydroxyphenylpyruvate dioxygenase (HPPD), leads to a characteristic bleaching of susceptible species .
|
-
-
- HY-116139R
-
|
|
Herbicide
|
Infection
|
|
Isoxaflutole (Standard) is the analytical standard of Isoxaflutole. This product is intended for research and analytical applications. Isoxaflutole (Merlin; RP-201772) is a selective herbicide for pre-emergence control of a wide range of important broadleaf and grass weeds in corn and sugarcane. Isoxaflutole is a precursor and delivery vector of diketonitrile (DKN), which is an inhibitor for 4-hydroxyphenylpyruvate dioxygenase (HPPD), leads to a characteristic bleaching of susceptible species .
|
-
-
- HY-N2596
-
-
-
- HY-N1133
-
|
|
Parasite
|
Infection
|
|
trans-Methylisoeugenol is an insect chemosterilant isolated from Acorus calamus L .
|
-
-
- HY-N3012
-
|
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Others
|
Others
|
|
Isovalerylshikonin (IVS) is a shikonin pigment is identified in the root epidermis of Echium italicum L .
|
-
-
- HY-N10893
-
|
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Others
|
Others
|
|
(-)-β-Peltatin-5-O-beta-D-glucopyranoside is an active compound. (-)-β-Peltatin-5-O-beta-D-glucopyranoside can be isolated from P. peltatum L .
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-
-
- HY-N11139
-
|
|
Others
|
Others
|
|
Solidagolactone II is a chloroalkaned diterpene isolated from S. uirgaurea L .
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-
-
- HY-N10901
-
|
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Others
|
Others
|
|
Droseron (compound 3) is a nature product that could be isolated from Plumbago zeylanica L .
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-
-
- HY-N11468
-
|
|
Others
|
Others
|
|
Homocapsaicin II is a pungent compound, that can be isolated from fruits of Capsicum annuum L .
|
-
-
- HY-N3621
-
|
|
Others
|
Others
|
|
Corchoionol C is a n-butanol-soluble fraction of the whole plant extract of Pulicaria undulate .
|
-
-
- HY-N12543
-
|
|
Others
|
Others
|
|
Peonidin 3-rutinoside is a natural product that can be isolated from Lonicera caerulea L .
|
-
-
- HY-163206
-
|
|
Cathepsin
SARS-CoV
|
Infection
|
|
SARS-CoV-2-IN-77 (compound 11e) is a cathepsin L and cathepsin S inhibitor with Ki values of 111 nM and 103 nM, respectively. SARS-CoV-2-IN-77 inhibits SARS-CoV-2 with an EC50 value of 38.4 nM in Calu-3 cells without showing cytotoxicity .
|
-
-
- HY-121909
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Piperic acid is a natural antioxidant and antibacterial agent. Piperic acid can be used in food preservation and human health .
|
-
- HY-171148
-
|
|
PROTACs
|
Cancer
|
|
F1-RIBOTAC is a ribonuclease-targeting chimeras (RIBOTACs). F1-RIBOTAC decreases QSOX1-a mRNA expression level in an RNase L-dependent manner. F1-RIBOTAC can be used for the research of cancer . (Pink: RNA ligand (HY-168460); Black: linker (HY-W008005); Blue: RNase L ligand (HY-168452))
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-
- HY-N11127
-
|
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Others
|
Others
|
|
Umuhengerin is a methoxylated flavone. Umuhengerin can be isolated from Cardiospermum corindum L .
|
-
- HY-N11465
-
|
|
Others
|
Others
|
|
(25R)-Spirost-4-ene-3,6,12-trione is a natural product, that can be isolated from T. terrestris L .
|
-
- HY-137910
-
|
|
Others
|
Others
|
|
Tembotrione is a drug that may reduce the
productivity of carrots. Tembotrione has the activity of reducing carrot stem
mass. Tembotrione can be used to study the total productivity of carrot
.
|
-
- HY-N11926
-
|
|
Others
|
Others
|
|
Ipalbine is a hexahydroindoliziae alkaloid that can be isolated from Ipomoea alba L .
|
-
- HY-137910R
-
|
|
Herbicide
|
Others
|
|
Tembotrione (Standard) is the analytical standard of Tembotrione. This product is intended for research and analytical applications. Tembotrione is a drug that may reduce the
productivity of carrots. Tembotrione has the activity of reducing carrot stem
mass. Tembotrione can be used to study the total productivity of carrot
.
|
-
- HY-N13223A
-
|
|
Others
|
Metabolic Disease
|
|
White Kidney Bean Extract (30:1) is the extract of White Kidney Bean. White Kidney Bean Extract (30:1) can be used in the study of obesity .
|
-
- HY-N1012
-
|
|
Others
|
Cancer
|
|
(-)-11,13-Dehydroeriolin (compound 9), a sesquiterpene lactone, is a nature product that could be isolated from Carpesium abrotanoides L. (-)-11,13-Dehydroeriolin has antiproliferative active. (-)-11,13-Dehydroeriolin can be used in research of cancer .
|
-
- HY-N2905
-
|
Asperglaucide
|
Cathepsin
|
Inflammation/Immunology
|
|
Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases .
|
-
- HY-N8273
-
|
|
Antibiotic
Fungal
|
Infection
|
|
Gliovirin is an antibiotic active against Pythium ultimum. Gliovirin is isolated from Gliocla-dium virens. Gliovirin may be derived from L,L-phenylalanine anhydride, which is also isolated from G. virens .
|
-
- HY-N1524
-
|
|
Others
|
Others
|
|
Quinovic acid is a natural product that can be isolated from Zygophyllum fabago L .
|
-
- HY-N1335
-
|
Rubianol h
|
Others
|
Others
|
|
Rubiarbonol B (Rubianol h) is an arborane type triterpenoid. Rubiarbonol B can be isolated from from the roots of Rubia cordifolia L .
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-
- HY-122530
-
|
|
Insecticide
|
Endocrinology
|
|
Juvocimene I is a potent juvenile hormone mimic. Juvocimene I can be isolated from the essential oil of sweet basil,Ocimum basilicum L .
|
-
- HY-B0744C
-
|
L-DFMO; L-RMI71782; L-α-difluoromethylornithine
|
Parasite
|
Cancer
|
|
L-Eflornithine (L-DFMO) is an enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 µM, and a Kinact of 0.15±0.03 min -1 .
|
-
- HY-P1939
-
|
Cyclo(L-prolyl-L-leucyl)
|
Fungal
|
Infection
|
|
Cyclo(L-Leu-L-Pro) is an inhibitory substance targeting to production of norsolorinic acid (NA，a precursor of aflatoxin)，which can be isolated from A. xylosoxidans NFRI-A1. Cyclo(L-Leu-L-Pro) inhibits accumulation of NA by A. parasiticus NFRI-95 and inhibits spore formation. Cyclo(L-Leu-L-Pro) inhibits aflatoxin production with an IC50 of 0.2 mg/mL in A. parasiticus SYS-4 .
|
-
- HY-W010789
-
-
- HY-106188
-
|
|
HIV Protease
|
Infection
|
|
L 756423 is a potent HIV protease inhibitor. L 756423 has the potential for the research of HIV infection .
|
-
- HY-W133962
-
|
Potassium L-(+)-tartaric acid
|
Biochemical Assay Reagents
|
Others
|
|
Potassium L-tartaric acid (Potassium L-(+)-tartaric acid) is a kind of biological materials or organic compounds that are widely used in life science research .
|
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- HY-117973
-
|
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Lipoxygenase
|
Inflammation/Immunology
|
|
L 691816 is a potent, selective and orally active inhibitors of 5-lipoxygenase. L 691816 can be used for the research of allergies and asthma .
|
-
- HY-P4257
-
|
|
Angiotensin-converting Enzyme (ACE)
|
Cardiovascular Disease
|
|
L-Isoleucyl-L-arginine is a dipeptide formed from L-isoleucine and L-arginine residues. L-Isoleucyl-L-arginine is a potent angiotensin-converting enzyme (ACE) inhibitor. L-Isoleucyl-L-arginine can be used for research of hypertension .
|
-
- HY-111271
-
|
|
Prostaglandin Receptor
|
Inflammation/Immunology
Endocrinology
|
|
L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite .
|
-
- HY-111271A
-
-
- HY-P1923
-
|
L-ASNase
|
Apoptosis
DNA/RNA Synthesis
|
Cancer
|
|
L-Asparaginase (L-ASNase) is a deamidating enzyme that catalyses the hydrolysis of L-asparagine and L-glutamine, and can be used for the research of acute lymphoblastic leukemia. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis .
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- HY-107734
-
|
|
Neuropeptide Y Receptor
|
Metabolic Disease
Endocrinology
|
|
L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure .
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- HY-128434
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-
- HY-A0282
-
|
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Amino Acid Derivatives
|
Metabolic Disease
Inflammation/Immunology
|
|
L-Ornithine L-aspartate is a stable salt of two natural nonessential L-amino acids with oral activity: ornithine and aspartic acid. L-Ornithine L-aspartate lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis. L-Ornithine L-aspartate also improves mitochondrial functions .
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- HY-78139
-
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L-(-)-Xylose
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Others
|
Others
|
|
L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type .
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- HY-W014102
-
-
- HY-W010042
-
|
L-(-)-Glucose
|
Fluorescent Dye
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Metabolic Disease
Cancer
|
|
L-Glucose (L-(-)-Glucose) is a stereoisomer of D-Glucose (HY-B0389), which does not readily enter the brain. L-Glucose can promote food intake. L-glucose is combined with a fluorescence detector to produce a fluorescent probe that can be used to visualize and characterize cancer cells. L-Glucose also can be used in the research to enhance memory in mice .
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-
- HY-101125A
-
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L-45 dihydrochloride
|
Epigenetic Reader Domain
|
Cancer
|
|
L-Moses (L-45) dihydrochloride is the first potent, selective, and cell-active p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor with a Kd of 126 nM .
|
-
- HY-103352
-
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L-235
|
Cathepsin
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Metabolic Disease
|
|
L-006235 (L-235) is a potent, selective, reversible and orally active inhibitor of cathepsin K, with an IC50 of 5 nM in bone resorption assay. L-006235 shows selectivity for cathepsin K (Ki=0.2 nM) over cathepsin B, cathepsin L, and cathepsin S (Ki=1, 6, and 47 μM, respectively). L-006235 can reduce collagen degradation and prevent bone loss .
|
-
- HY-101125
-
L-Moses
2 Publications Verification
L-45
|
Epigenetic Reader Domain
|
Cancer
|
|
L-Moses (L-45) is the first potent, selective, and cell-active p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor with a Kd of 126 nM .
|
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- HY-108537
-
|
|
Reactive Oxygen Species
|
Inflammation/Immunology
|
|
L 012 sodium salt a luminol-based chemiluminescent (CL) probe, is widely used in vitro and in vivo to detect NADPH oxidase (Nox)-derived superoxide (O2 •−) and identify Nox inhibitors .
|
-
- HY-138903
-
|
L-HCA
|
iGluR
|
Neurological Disease
|
|
L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders .
|
-
- HY-W068839
-
-
- HY-W009686
-
-
- HY-W008733
-
-
- HY-B0400A
-
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L-Glucitol
|
Biochemical Assay Reagents
|
Others
|
|
L-Sorbitol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-108564
-
|
|
Prostaglandin Receptor
|
Cardiovascular Disease
|
|
L 655240 is thromboxane antagonist. L 655240 attenuates early ischemia- and reperfusion-induced arrhythmias in a canine model of coronary artery occlusion. L 655240 also involves in cancer and autoimmune disorders .
|
-
- HY-101349A
-
|
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Dopamine Receptor
|
Neurological Disease
|
|
L 741742 hydrochloride is an orally active and selective antagonist of hD4 receptors. L 741742 hydrochloride has a good brain penetration. L 741742 hydrochloride can be used in study nervous system disorders, particularly schizophrenia .
|
-
- HY-W017200
-
-
- HY-105207
-
|
|
HIV
|
Infection
|
|
L 696229 is a specific inhibitor ofhuman immunodeficiency virus type 1 (HIV-1)reverse transcriptase (RT) activity that possesses antiviral activity .
|
-
- HY-118488
-
-
- HY-129664
-
|
|
Others
|
Inflammation/Immunology
|
|
L 683519, one of the impurities of tacrolimus, is an immunosuppressant. L 683519 can inhibit the activity of FK-506 binding protein .
|
-
- HY-15007
-
|
|
Oxytocin Receptor
|
Endocrinology
|
|
L 366509 is a spiroindenylpiperidine camphorsulfonamide oxytocin (OT) antagonist. Modifications led to a new series of o-tolylpiperazine (TP) camphorsulfonamides, exhibiting high affinity for OT receptors and selectivity over arginine vasopressin receptors. Notably, compound 7 (L-368,899) showed excellent OT receptor affinity, potency in inhibiting OT-stimulated uterine contractions, good aqueous solubility, and oral bioavailability in multiple species. Compound 7 has entered clinical testing as an oral and intravenous tocolytic agent. Molecular modeling suggests the TP camphorsulfonamide structure mimics the D-AA2-Ile3 dipeptide, crucial in potent OT antagonists .
|
-
- HY-117952
-
|
|
Neurokinin Receptor
|
Neurological Disease
|
|
L 743310 is a non-peptide, selective antagonist of the human neurokinin hNK1 receptor, with high affinity for primate and cloned human hNK1 receptors and lower affinity for rodent NK1 receptors. L 743310 inhibits resiniferatoxin-induced plasma protein extravasation in guinea pig esophagus. L 743310 has a dose-dependent inhibitory effect on cisplatin-induced emesis .
|
-
- HY-118261
-
|
|
Elastase
|
Inflammation/Immunology
|
|
L 659286 is an inhibitor of human polymorphonuclear leukocyte elastase (PMN elastase) (Ki=0.4 μM). Intratracheal injection of L 659286 can induce lung injury in hamsters.
|
-
- HY-120390
-
|
|
HIV Protease
HIV
|
Infection
|
|
L 694746 is the metabolite of L-689502 (HY-U00261). L 694746 is an inhibitor for HIV-1 protease with an IC50 of 1 nM and a Ki of 0.34 nM .
|
-
- HY-120491
-
|
|
Thrombin
|
Cardiovascular Disease
|
|
L 722151 is a competitive inhibitor for factor XIIIa with Ki of 49 µM. L 722151 accelerates tissue plasminogen activator-catalyzed clot dissolution, and exhibits antithrombotic efficacy .
|
-
- HY-101349
-
|
|
Dopamine Receptor
Apoptosis
|
Neurological Disease
Cancer
|
|
L 741742 is a dopamine receptor D4 (DRD4) antagonist that selectively inhibits glioblastomas (GBM) growth in vitro and in vivo, synergyed with Temozolomide (TMZ) (HY-17364). L 741742 disrupts in effectors PDGFRβ/ERK1/2 and mTOR signaling. Additionally, L 741742 disrupts endolysosmal function compromising the autophagy-lysosomal degradation pathway, followed by G0/G1 cell cycle arrest and Apoptosis. L 741742 is promising for research of GBM and neurogenesis .
|
-
- HY-124887
-
-
- HY-118459
-
-
- HY-125304
-
|
|
Neurokinin Receptor
|
Endocrinology
|
|
L 363851 is a Neurokinin 2 receptor agonist, and induces the contractile response of tracheal smooth muscle devoid of epithelium (IC50 of 3.2 nM) and phosphoinositide hydrolysis (IC50 of 36 μM).
|
-
- HY-119025
-
-
- HY-117627
-
|
|
Angiotensin Receptor
|
Cardiovascular Disease
|
|
L 158338 is an angiotensin II receptor antagonist. L 158338 alleviates acidosis and increases coronary blood flow during the ischemic period and increases coronary blood flow during the reperfusion period. L 158338 can be used to study myocardial injury during ischemia and reperfusion .
|
-
- HY-133854
-
-
- HY-116973
-
|
|
HIV
|
Infection
|
|
L-738372 is a non-competitive reversible inhibitor of HIV-1 reverse transcriptase (RT) with an inhibition constant (Ki) of 140 nM against dTTP. When combined with any nucleoside analogs (such as azidothymidine triphosphate, didexoyinosine triphosphate, or didexoycytidine triphosphate), L-738372 exhibits synergistic inhibition of RT activity. L-738372 has 2-3 times more inhibitory potency against the azidothymidine-resistant RT (D67N, K70R, T215Y, K219Q) compared to the wild-type RT. L-738372 holds promise for research in the field of HIV virus treatment .
|
-
- HY-117591
-
|
|
Elastase
|
Inflammation/Immunology
Cancer
|
|
L-684248 is an inhibitor of human leukocyte elastase (HLE). L-684248 exerts its inhibitory effect on HLE by forming a covalent bond with the active site of the enzyme, showing potential value for applications in anti-inflammatory and anti-tumor research .
|
-
- HY-118209
-
|
|
Dopamine Receptor
5-HT Receptor
|
Neurological Disease
|
|
L-646462 is an antagonist of dopamine and 5-HT, with selectivity for the peripheral system (the central/peripheral activity ratio of L-646462 is 143). L-646462 can be used in research related to nausea, vomiting, and associated neurological disorders .
|
-
- HY-135728
-
-
- HY-105216
-
-
- HY-105396
-
-
- HY-114840
-
|
|
Ras
|
Cancer
|
|
L 731734 is a prodrug of L-731735 (HY-129273), and inhibits Ras processing in cells transformed with v-ras .
|
-
- HY-116610
-
|
|
COX
|
Inflammation/Immunology
|
|
L 748780 (compound 2) is a selectivity COX-2 inhibitor with the IC50 values of 0.5 μM and ＞ 100 μM for COX-2 and COX-1, respectively .
|
-
- HY-23093
-
-
- HY-113725
-
|
|
HMG-CoA Reductase (HMGCR)
|
Others
|
|
L 668411 is a β-lactone inhibitor with activity against 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis. L 668411 inhibits rat liver cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase and [14C] acetate incorporation into sterols in cultured Hep G2 cells, and the inhibition appears to be irreversible in cells but reversible in cultured cells and animals.
|
-
- HY-118196
-
-
- HY-119012
-
-
- HY-120862
-
-
- HY-116540
-
|
|
Adenylate Cyclase
|
Others
|
|
L 858051 is an analog of forskolin that activates adenylate cyclase while also having modulatory effects on intracellular cAMP levels, particularly enhancing the CNG current in cardiac myocytes.
|
-
- HY-124391
-
-
- HY-121720
-
-
- HY-W104816
-
|
|
Others
|
Others
|
|
L-Tyrosyl-L-glutamic acid is an amino acid penetrase GAP1 inhibitor .
|
-
- HY-W507009
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
L-Arginyl-L-alanine is a dipeptide, is a vascular smooth muscle-derived relaxing factor. L-Arginyl-L-alanine increases the smooth muscle levels of cyclic GMP and nitrite in endothelium-denuded arterial rings .
|
-
- HY-W011607
-
|
|
Amino Acid Derivatives
|
Others
|
|
L-Alanyl-L-tryptophan is a dipeptide formed from L-alanyl and L-tryptophan, and is also a metabolite. L-Alanyl-L-tryptophan can be adsorbated on the surface of gold nanoparticles, and the Raman signal can be enhanced by SERS technology to obtain the enhanced Raman spectroscopy .
|
-
- HY-N9588
-
|
|
Others
|
Cancer
|
|
Pedaliin is a bioactive component obtained from the ethanol extract of Sesame (Sesamum indicum L.) leaves (SLs). Pedaliin shows in vitro antioxidant and anti-colon cancer efficacy with radical scavenging activity and ferric reducing antioxidant power (FRAP) .
|
-
- HY-N0455B
-
|
(S)-(+)-Arginine (L-glutamate)
|
Endogenous Metabolite
NO Synthase
|
Metabolic Disease
|
|
L-Arginine L-glutamate ((S)-(+)-Arginine L-glutamate) is the nitrogen donor for synthesis of nitric oxide. L-Arginine L-glutamate can be used for upper gastrointestinal hypofunction or dysfunction like functional dyspepsia research .
|
-
- HY-N1436
-
|
L-Abrine; L-N-Methyltryptophan; N-α-Methyl-L-tryptophan
|
Others
|
Inflammation/Immunology
|
|
L-(+)-Abrine, a lethal albumin found in Abrus precatorius seeds, is an acute toxic alkaloid and chemical marker for abrin.
|
-
- HY-Z0291
-
|
Isopropyl L-alaninate; L-Alanine 2-propyl ester; L-Alanine isopropyl ester; O-Isopropyl-L-alanine
|
Amino Acid Derivatives
|
Others
|
|
L-Alanine isopropyl ester is an alanine derivative .
|
-
- HY-12115
-
|
Nω-nitro-L-arginine; L-NOARG; L-NG-Nitroarginine
|
NO Synthase
|
Cardiovascular Disease
|
|
NG-nitro-L-arginine (Nω-nitro-L-arginine) is a NO Synthase inhibitor, with Kis of 0.61 μM (nNOS), 4.28 μM (iNOS), 0.72 μM (eNOS) respectively. NG-nitro-L-arginine inhibits endothelium-derived relaxing factor (EDRF) formation and release. NG-nitro-L-arginine inhibits portal-systemic shunting in portal-hypertensive rats, and increases blood pressure .
|
-
- HY-15129
-
|
L-Serine O-phosphate; L-SOP
|
mGluR
Endogenous Metabolite
|
Neurological Disease
|
|
O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2 .
|
-
- HY-101590
-
-
- HY-19369
-
|
L-685,458
|
γ-secretase
Apoptosis
|
Neurological Disease
Cancer
|
|
L-685458 is a potent transition state analog (TSA) γ-secretase inhibitor (GSI). L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimer’s disease (AD) and cancers .
|
-
- HY-100781A
-
L-AP4
1 Publications Verification
L-APB
|
mGluR
|
Neurological Disease
|
|
L-AP4 (L-APB) is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively .
|
-
- HY-N0666C
-
|
Sodium L-aspartate
|
Endogenous Metabolite
|
Others
|
|
L-Aspartic aicd sodium is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly .
|
-
- HY-100781B
-
|
L-APB monohydrate
|
mGluR
|
Neurological Disease
|
|
L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively .
|
-
- HY-P1934A
-
|
|
Fungal
Bacterial
IFNAR
Reactive Oxygen Species
|
Infection
Inflammation/Immunology
Cancer
|
|
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay .
|
-
- HY-P2124
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candida albicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research .
|
-
- HY-N8631
-
|
Acetylschisantherin L
|
NO Synthase
|
Inflammation/Immunology
|
|
O-Acetylschisantherin L (Acetylschisantherin L) is a natural lignan, which exhibits inhibitory effects on LPS-induced NO production in BV-2 cells with an IC50 of 23.1 μM .
|
-
- HY-N0059A
-
-
- HY-P1938
-
|
|
Bacterial
|
Infection
|
|
Cyclo(L-Pro-L-Val) is a 2,5-diketopiperazine, with toxic activity against phytopathogenic microorganisms (such as R. fascians LMG 3605). Cyclo(L-Pro-L-Val) shows toxicity similar to Chloramphenicol (HY-B0239) with comparable concentration. Cyclo(L-Pro-L-Val) can also inhibit gram-positive phytopathogenic bacterium. Cyclo(L-Pro-L-Val) has potential development as biopesticide .
|
-
- HY-121982
-
|
|
Fungal
|
Infection
|
|
Cyclo(L-Phe-L-Val) is a potent inhibitor of enzymes isocitrate lyase (ICL) (IC50=27 μg/mL). cyclo(L-Phe-L-Val) inhibits the gene transcription of ICL in C. albicans under C2-carbon-utilizing conditions .
|
-
- HY-118090
-
|
|
Others
|
Others
|
|
L-γ-Glutamyl-L-glutamic acid is the isomer of D-γ-Glutamyl-D-glutamic acid (HY-118090A), and can be used as an experimental control. D-γ-Glutamyl-D-glutamic acid is a poly(γ-glutamic acid) of clusters of D- and D-glutamic acid repeating units in a linear chain .
|
-
- HY-N12056
-
|
|
Fungal
|
Infection
|
|
Cyclo(L-leucyl-L-valyl) inhibits Aflatoxin production by Aspergillus parasiticus.Cyclo(L-leucyl-L-valyl) inhibits transcription of the Aflatoxin-related genes aflR, hexB, pksL1, and dmtA. .
|
-
- HY-P5924
-
|
|
Bacterial
|
Infection
|
|
L-K6L9 shows antimicrobial and antibiofilm activities against P. aeruginosa from cystic fibrosis patients. L-K6L9 is stable and resistant to degradation by cystic fibrosis sputum proteases and will not induce bacterial resistance .
|
-
- HY-122359B
-
|
L-Centchroman fumarate; L-Ormeloxifene fumarate
|
Estrogen Receptor/ERR
|
Others
|
|
Levormeloxifene (fumarate) is a stable salt form of Levormeloxifene. Levormeloxifene (fumarate) is an estrogen receptor modulator that plays an important role in prevention of postmenopausal bone loss .
|
-
- HY-114788
-
|
L-Lysyl-L-cysteine
|
Others
|
Others
|
|
Lysylcysteine (L-Lysyl-L-cysteine) is a dipeptide composed of lysine and cysteine.
|
-
- HY-W014102R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
Inflammation/Immunology
|
|
L-Alanyl-L-glutamine (Standard) is the analytical standard of L-Alanyl-L-glutamine. This product is intended for research and analytical applications. L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations .
|
-
- HY-101590A
-
|
L 16726 dihydrochloride
|
Parasite
|
Infection
|
|
Symetine dihydrochloride (L 16726 dihydrochloride) is the dihydrochloride form of Symetine (HY-101590). Symetine dihydrochloride exhibits antiprotozoal activity aginst Entamoeba histolytica, and ameliorates the amebic liver abscess in guinea pig model .
|
-
- HY-122359
-
|
L-Centchroman; L-Ormeloxifene
|
Estrogen Receptor/ERR
|
Endocrinology
Cancer
|
|
Levormeloxifene (L-Centchroman) is a selective estrogen receptor modulator (SERM), which prevents and ameliorates postmenopausal osteoporosis. Levormeloxifene causes multiple adverse gynecological effects .
|
-
- HY-N13025
-
|
Verrucarin L acetate
|
Fungal
|
Infection
|
|
8-Acetylverrucarin L (Verrucarin L acetate) is a mycotoxin, which exhibits antitumor and antimicrobial activities. 8-Acetylverrucarin L exhibits cytotoxicity to cancer cells HCT116 and A2780S, with IC100 of 9.77 and 9.77 ng/mL. 8-Acetylverrucarin L exhibits antifungal activity against Saccharomyces cerevisiae, Candida albicans and Geotrichum candidum .
|
-
- HY-117644
-
|
(Rac)-L-754142
|
Endothelin Receptor
|
Cardiovascular Disease
|
|
L-749329 ((Rac)-L-754142) is an ETA and ETB receptor antagonist, with Kis of 0.062 nM and 2.25 nM for ETA and ETB respectively. L-749329 inhibits ET-1-stimulated signaling .
|
-
- HY-B0522C
-
|
L-(+)-α-Aminobenzylpenicillin
|
Antibiotic
|
Infection
|
|
L-(+)-Ampicillin (L-(2S) ampicillin) is the L-isomer of Ampicillin (HY-B0522). Ampicillin is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria .
|
-
- HY-W040055A
-
|
L-erythro-Neopterin
|
mAChR
|
Neurological Disease
Metabolic Disease
|
|
L-(-)-Neopterin (L-erythro-Neopterin) is a cholinergic receptor that acts as a competitive antagonist, countering the inhibitory effects of pteridine diuretics on the growth of Crithidia fasciculata. L-(-)-Neopterin can be used in research related to the nervous system and purine metabolism .
|
-
- HY-122323
-
|
Leucylarginine
|
Amino Acid Derivatives
|
Others
|
|
L-Leucyl-L-arginine (Leucylarginine) is a compound that inhibits the analgesic effect of systemically administered L-arginine in a carrageenan-induced hyperalgesia model in mice when administered intracerebroventricularly.
|
-
- HY-23093R
-
|
|
Angiotensin-converting Enzyme (ACE)
Drug Metabolite
|
Cardiovascular Disease
|
|
L-Aspartyl-L-phenylalanine (Standard) is the analytical standard of L-Aspartyl-L-phenylalanine. This product is intended for research and analytical applications. L-Aspartyl-L-phenylalanine is a metabolite of aspartame that can inhibit angiotensin converting enzyme (ACE) purified from rabbit lungs with a Ki of 11 μM .
|
-
- HY-B0744D
-
|
L-DFMO monohydrochloride; ; L-RMI71782 monohydrochloride; L-α-difluoromethylornithine monohydrochloride
|
Parasite
|
Cancer
|
|
L-Eflornithine monohydrochloride (L-DFMO monohydrochloride) is an enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 µM, and a Kinact of 0.15±0.03 min -1 .
|
-
- HY-100714B
-
|
L-APV; L-2-Amino-5-phosphonovaleric acid
|
iGluR
|
Neurological Disease
|
|
L-AP5 (L-APV; L-2-Amino-5-phosphonovaleric acid) is an NMDA antagonist and is the isomer of D-AP5 (HY-100714A).
L-AP5 shows a relatively weak amino acid and synaptic blocking activity .
|
-
- HY-106376A
-
|
L-Buthionine sulfoximine; L-BSO
|
Ferroptosis
|
Cancer
|
|
L-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.
|
-
- HY-106376C
-
|
L-Buthionine sulfoximine hydrochloride; L-BSO hydrochloride
|
Ferroptosis
|
Metabolic Disease
Cancer
|
|
L-Buthionine-(S,R)-sulfoximine hydrochloride is a cell-permeable, potent, fast acting, orally active and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively .
|
-
- HY-16009B
-
|
(+)-Phenserine L-Tartrate; ANVS401 L-Tartrate
|
Amyloid-β
|
Cancer
|
|
Buntanetap (L-Tartrate) is an orally administered small molecule inhibitor of several neurotoxic proteins. Buntanetap reduces amyloid precursor protein (APP) production by blocking its mRNA translation .
|
-
- HY-137031
-
|
XDE-175-L; 3'-O-Ethyl spinosyn L
|
Insecticide
|
Infection
|
|
Spinetoram L (XDE-175-L) is a minor component of Spinetoram. Spinetoram is a kind of green and efficient insecticide with a broad range of action against various insects .
|
-
- HY-133721
-
|
|
HBV
|
Infection
Inflammation/Immunology
|
|
Chamaechromone is a biflavonoid ingredient isolated from the roots of Stellera chamaejasme L. (Thymelaeaceae). Chamaechromone possesses anti-hepatitis B virus (HBV) effects against the surface antigen of HBV (HBsAg) secretion and has insecticidal activities .
|
-
- HY-A0097A
-
|
Antibiotic MDL-507 sodium; MDL-507 sodium
|
Antibiotic
HIV
SARS-CoV
|
Infection
|
|
Teicoplanin sodium is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin sodium shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity .
|
-
- HY-N7332
-
|
|
P-glycoprotein
|
Cancer
|
|
Pepluanin A is a natural compound isolated from Euphorbia peplus L. Pepluanin A shows a very high activity for a jatrophane diterpene, outperforming Cyclosporin A by a factor of at least 2 in the inhibition of Pgp-mediated Daunomycin (HY-13062A) transport [1]
|
-
- HY-W002112
-
|
Nornicotine
|
Endogenous Metabolite
Drug Metabolite
|
Neurological Disease
|
|
(±)-Nornicotine is the primary metabolite of nicotine that is formed through demethylation of nicotine in the genus Nicotiana tabacum L. (±)-Nornicotine is a precursor of tobacco-specific nitrosamine N-nitrosonornicotine. (±)-Nornicotine has detrimental effects to human health .
|
-
- HY-W002112R
-
|
|
Endogenous Metabolite
Drug Metabolite
|
Neurological Disease
|
|
(±)-Nornicotine (Standard) is the analytical standard of (±)-Nornicotine. This product is intended for research and analytical applications. (±)-Nornicotine is the primary metabolite of nicotine that is formed through demethylation of nicotine in the genus Nicotiana tabacum L. (±)-Nornicotine is a precursor of tobacco-specific nitrosamine N-nitrosonornicotine. (±)-Nornicotine has detrimental effects to human health .
|
-
- HY-W134004
-
|
L-(+)-Tartaric acid ammonium
|
Biochemical Assay Reagents
|
Others
|
|
L-Tartaric acid (ammonium) (L-(+)-Tartaric acid (ammonium)) is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-134240
-
|
Magnesium L-threonate
|
Drug Metabolite
|
Metabolic Disease
|
|
L-Threonic acid magnesium salt is the enantiomer of Threonic acid and a metabolite of vitamin C. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent .
|
-
- HY-15252
-
-
- HY-N0390
-
|
L-Glutamic acid 5-amide
|
mGluR
Endogenous Metabolite
Ferroptosis
|
Metabolic Disease
Cancer
|
|
L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells .
|
-
- HY-B0166
-
-
- HY-14166
-
|
L 663536
|
FLAP
Leukotriene Receptor
PPAR
Apoptosis
|
Cancer
|
|
MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis .
|
-
- HY-101414
-
-
- HY-112171
-
|
|
Endogenous Metabolite
CaSR
|
Others
|
|
γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is a proteolytic breakdown product of larger proteins. γ-L-Glutamyl-L-alanine is a natural substrate of the γ-Glutamylcyclotransferase. γ-L-Glutamyl-L-alanine is a positive modulator of calcium-sensing receptor (CaR) function .
|
-
- HY-101552B
-
|
o,o'-Dityrosine hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
L,L-Dityrosine hydrochloride (o,o'-Dityrosine hydrochloride) is a constituent of acid hydrolysates of a number of biological materials, including the insect cuticular resilin .
|
-
- HY-101552A
-
|
o,o'-Dityrosine
|
Amino Acid Derivatives
|
Others
|
|
L,L-Dityrosine (o,o'-Dityrosine) is a constituent of acid hydrolysates of a number of biological materials, including the insect cuticular resilin .
|
-
- HY-B1148B
-
|
Altafur L-tartrate
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Furaltadone L-tartrate (Altafur L-tartrate), a nitrofuran agent, has the potential for the study in infections of chickens with salmonella enteritidis. Furaltadone is inhibitory and bactericidal in vitro for staphylococci .
|
-
- HY-N6960
-
|
Stepholidine; (-)-Stepholidine; L-SPD
|
Dopamine Receptor
|
Neurological Disease
|
|
L-Stepholidine (Stepholidine) exhibits mixed dopamine D1 receptor agonist and D2 antagonist properties. L-Stepholidine has neuroprotective effect and inhibits Heroin-induced reinstatement. L-Stepholidine is a potential medication for the research of opiate addiction .
|
-
- HY-108591
-
|
R-L3
|
Potassium Channel
|
Cardiovascular Disease
|
|
L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1)/mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes .
|
-
- HY-100586
-
|
(±)-Ibuprofen L-lysine
|
COX
Apoptosis
Parasite
|
Infection
Inflammation/Immunology
Cancer
|
|
Ibuprofen ((±)-Ibuprofen) L-lysine is a potent orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen L-lysine inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen L-lysine is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen L-lysine can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .
|
-
- HY-W109973
-
|
L-(+)-Tartaric acid diammonium
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
L-Tartaric acid diammonium (L-(+) -tartaric acid) is an orally active weak organic acid that can be isolated from grapes. L-Tartaric acid diammonium has vasodilatory and antihypertensive effects. L-Tartaric acid diammonium can be used as flavorings and antioxidants in a range of foods and beverages. L-Tartaric acid diammonium can be used in laser frequency doubling and optical limiting applications .
|
-
- HY-W048828
-
-
- HY-W048831
-
-
- HY-122811
-
-
- HY-W038703
-
-
- HY-142006
-
|
(-)-JA-L-Ile
|
Endogenous Metabolite
|
Others
|
|
(-)-Jasmonoyl-L-isoleucine ((-)-JA-L-Ile) is an inactive endogenous hormone. (-)-Jasmonoyl-L-isoleucine is an enantiomer of (+)-JA-L-Ile .
|
-
- HY-130687
-
|
L-ribo-2-Hexulose
|
Biochemical Assay Reagents
|
Others
|
|
L-Psicose is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-14166A
-
|
L 663536 sodium salt
|
PPAR
Apoptosis
Leukotriene Receptor
FLAP
|
Cancer
|
|
MK-886 (L 663536) sodium salt is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 sodium salt is also a non-competitive PPARα antagonist and can induce apoptosis .
|
-
- HY-111271B
-
|
|
Prostaglandin Receptor
Drug Isomer
|
Inflammation/Immunology
Endocrinology
|
|
(R)-L 888607 is the isomer of L 888607 (HY-111271), and can be used as an experimental control. L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite .
|
-
- HY-W019599
-
-
- HY-107340
-
-
- HY-128425A
-
|
L-Ureidosuccinic acid
|
Endogenous Metabolite
|
Others
|
|
N-Carbamoyl-L-aspartic acid is intermediate of pyrimidine (HY-Y0519) metabolism. N-Carbamoyl-L-aspartic acid can be used to measure enzyme activity of dihydroorotase (DHOse) .
|
-
- HY-W337739
-
|
Monopotassium L-glutamate
|
Others
|
Others
|
|
L-Glutamic acid monopotassium salt is a food additive and flavor enhancer that can reduce the harmful effects of lithium .
|
-
- HY-163383
-
|
L-EOP
|
Bacterial
|
Infection
|
|
L-Ent-oxPt IV (L-EOP) is a Oxaliplatin (HY-17371)-based siderophore-platinum conjugate. L-Ent-oxPt IV exhibits selectivity towards Escherichia coli and antibacterial activity through DNA damage .
|
-
- HY-118050
-
|
L-420
|
Sodium Channel
Endogenous Metabolite
|
Cardiovascular Disease
|
|
L589420-0-2 (L-420) is a sodium pump inhibitor with inhibitory activity in human erythrocytes. L589420-0-2 can regulate the concentration of intracellular sodium ions, thereby affecting the electrophysiological properties of cells. L589420-0-2 may also play an important role in the inhibition of cardiovascular diseases .
|
-
- HY-129263
-
|
Ile-Val
|
Ser/Thr Protease
|
Cancer
|
|
L-Isoleucyl-L-valine (Ile-Val) is a dipeptide that induces the bovine trypsinogen-trypsin transition .
|
-
- HY-16384
-
|
Antibiotic L 156602; PD 124966
|
Complement System
|
Inflammation/Immunology
|
|
L-156602 is a C5a receptor antagonist. L-156602 inhibits inflammation, and the migration of monocytes and neutrophils to the infiltrating site in mouse inflammatory models. L-156602 suppresses the efferent phase of delayed-type hypersensitivity (DTH) .
|
-
- HY-D0187
-
-
- HY-118391
-
|
N-Benzoyl-L-phenylalanine; Bz-L-Phe-OH
|
Others
|
Others
|
|
Benzoyl-L-phenylalanine (N-Benzoyl-L-phenylalanine) is a chorisate mutase-prephenate dehydrogenase inhibitor .
|
-
- HY-W010162
-
|
L-Alanyl-L-alanine; Ala-Ala
|
Amino Acid Derivatives
|
Others
|
|
H-Ala-Ala-OH (L-Alanyl-L-alanine; Ala-Ala) is a nonpolar dipeptide that is absorbed by human intestinal Caco-2 cells. The transport of alanine (Ala), like proton/amino acid symport, can lead to cytoplasmic acidification .
|
-
- HY-P1171
-
-
- HY-15121
-
|
L-Glutamic Acid γ-ethyl amide; Nγ-Ethyl-L-glutamine
|
Apoptosis
Endogenous Metabolite
Reactive Oxygen Species
|
Neurological Disease
Cancer
|
|
L-Theanine (L-Glutamic Acid γ-ethyl amide) is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective, anticancer and anti-oxidative activities. L-Theanine can pass through the blood–brain barrier and is orally active .
|
-
- HY-144345S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
L-GAMMA-glutamyl-L-cysteinyl-L-lysine- 13C5, 15N is a 15N-labeled and 13C-labled labeled L-GAMMA-glutamyl-L-cysteinyl-L-lysine[1].
|
-
- HY-165118
-
|
L-Carnitine pentadecanoyl ester chloride; L-Pentadecanoylcarnitine chloride; C15:0 Carnitine chloride
|
Biochemical Assay Reagents
|
Others
|
|
Pentadecanoyl-L-carnitine (chloride) 是一种生化试剂。
|
-
- HY-114928
-
|
L 3937; Dideiodo Amiodarone
|
Drug Intermediate
|
Others
|
|
Deiodoamiodarone (L 3937; Dideiodo Amiodarone) is an intermediate of amiodarone. Amiodarone is a potent calmodulin antagonist .
|
-
- HY-79136
-
|
SOM230 L-aspartate
|
Somatostatin Receptor
|
Endocrinology
Cancer
|
|
Pasireotide (SOM230) L-aspartate salt, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide L-aspartate salt exhibits antisecretory, antiproliferative, and proapoptotic activity .
|
-
- HY-100385
-
|
Cyclo(L-Pro-L-Trp)
|
PI3K
Bacterial
|
Infection
|
|
Brevianamide F (Cyclo(L-Pro-L-Trp)) is a mycotoxin isolated from Colletotrichum gloeosporioides, with antibacterial activity. Brevianamide F shows potent PI3Kα inhibitory activity with an IC50 of 4.8 μM .
|
-
- HY-B0166A
-
|
Sodium ascorbate; Sodium L-ascorbate; Vitamin C sodium salt
|
Reactive Oxygen Species
Calcium Channel
Apoptosis
Endogenous Metabolite
|
Cancer
|
|
L-Ascorbic acid sodium salt (Sodium ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor .
|
-
- HY-B2188
-
|
L-S-Methylcysteine
|
Reactive Oxygen Species
|
Neurological Disease
Metabolic Disease
|
|
S-Methyl-L-cysteine is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities.
|
-
- HY-W016628
-
|
L-Gulonolactone
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.
|
-
- HY-N1480
-
|
6-Desoxygalactose; L-(-)-Fucose; L-Galactomethylose
|
Endogenous Metabolite
Parasite
|
Infection
Metabolic Disease
Cancer
|
|
(-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interactions. (-)-Fucose is orally active, inhibits CL11-induced inflammatory response in kidney and tumor growth .
|
-
- HY-15461A
-
|
PF-04971729 L-pyroglutamic acid
|
SGLT
|
Metabolic Disease
|
|
Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2 . Has the potential for the treatment of type 2 diabetes mellitus .
|
-
- HY-B1716
-
|
L-5-HTP; Oxitriptan
|
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
|
L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist . L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia .
|
-
- HY-103701
-
|
2-Phospho-L-ascorbic acid
|
Phosphatase
Reactive Oxygen Species
Endogenous Metabolite
|
Metabolic Disease
|
|
L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .
|
-
- HY-121513
-
|
2'-Deoxy-L-cytidine; L-dC
|
HBV
|
Infection
|
|
Torcitabine (2'-Deoxy-L-cytidine) is an antiviral agent. Torcitabine has the potential for chronic hepatitis B virus infection treatment .
|
-
- HY-108546
-
|
3-Phosphono-L-alanine
|
mGluR
|
Neurological Disease
|
|
L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC50s of 368 μM and 2087 μM, respectively .
|
-
- HY-76511
-
-
- HY-W008642
-
-
- HY-N0666D
-
-
- HY-79861
-
-
- HY-107373A
-
-
- HY-P1315
-
|
Glycylglycyl-L-tyrosyl-L-arginine
|
Cathepsin
|
Others
|
|
Papain inhibitor (Glycylglycyl-L-tyrosyl-L-arginine) acts as an effective competitive inhibitor to papain, with a Ki of 9 μM at pH 6.2 .
|
-
- HY-135627
-
|
cyclo(L-Hyp-L-Ser)
|
Endogenous Metabolite
|
Others
|
|
JBP485 (cyclo-trans-4-L-hydroxyprolyl-L-serine) is a dipeptide with anti-hepatotoxic and wound healing properties. JBP485 can be used for research of various kinds of corneal epithelial diseases .
|
-
- HY-P2807J
-
|
|
Lactate Dehydrogenase
|
Metabolic Disease
|
L-Lactate Dehydrogenase (L-LDH), pig muscle is an L-lactate dehydrogenase found in pig muscle, mainly present in anaerobic tissues (skeletal muscle, red blood cells). L-Lactate Dehydrogenase (L-LDH), pig muscle can interact with acidic liposomes at low pH, causing protein to adsorb onto the liposomes and inhibit enzyme activity. The IC50 values for L-Lactate Dehydrogenase (L-LDH), pig muscle are 0.05 μM for cardiolipin and 1.3 μM for phosphatidylserine liposomes .
|
-
- HY-137157
-
-
- HY-16743A
-
|
Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid)
|
Glucosylceramide Synthase (GCS)
|
Metabolic Disease
|
|
Ibiglustat (Venglustat) L-Malic acid is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat L-Malic acid can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease .
|
-
- HY-P1173
-
|
Myristoylated L 803; GSK-3β Inhibitor XIII
|
GSK-3
Amyloid-β
|
Neurological Disease
|
|
L803-mts (Myristoylated L 803) is a selective and substrate-competitive GSK-3 peptide inhibitor (IC50: 40 μM). L803-mts also reduces Aβ deposits and ameliorates cognitive deficits in 5XFAD mice. L803-mts shows antidepressive effect in the forced swimming test .
|
-
- HY-79415
-
-
- HY-130673
-
|
|
NO Synthase
|
Cardiovascular Disease
|
|
L-NABE is a nitric oxide (NO) synthase inhibitor. L-NABE is also a potent endothelium dependent vasoconstrictor and inhibitor of relaxation .
|
-
- HY-W017894
-
|
|
Biochemical Assay Reagents
|
Others
|
|
TPO-L is a photoinitiator for the 3D printing of resin that promotes two-photon induced polymerization. The two-photon absorption cross-section spectrum of Lucirin TPO-L shows a maximum of 1.2 GM at 610 nm. Despite its small two-photon absorption cross-section, Lucirin TPO-L exhibits high polymerization quantum yields .
|
-
- HY-W002450
-
|
|
Drug Derivative
|
Cardiovascular Disease
|
|
L-Cyclohexylalanine is an amino acid derivative. L-Cyclohexylalanine modifies an atrial natriuretic peptide, regulates homeostasis of body fluid and blood pressure homeostasis and vasodilation activity .
|
-
- HY-W008351
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
L-Ribose, a non-naturally occurring pentose, is an ideal starting material for use in synthesizing L-nucleosides analogues. Many anticancer and antiviral drugs are synthesized based on a backbone of L-Ribose and its derivatives .
|
-
- HY-112824
-
|
|
Angiotensin Receptor
|
Cardiovascular Disease
|
|
L-162313 is a non-peptide angiotensin II AT1 and AT2 receptor agonist, with IC50 values of 1.1 and 2.0 nM for AT1 and AT2 receptor, respectively. L-162313 can be used for the research of vasoconstriction, aldosterone release, and cardiovascular growth .
|
-
- HY-100930
-
-
- HY-N11773
-
|
|
PPAR
|
Metabolic Disease
|
|
Gancaonin L is an isoflavone, that can be isolated from Glycyrrhiza glabra roots. Gancaonin L exhibits significant PPAR-γ ligand-binding activity. Gancaonin L can be used for anti-diabetes and anti-obesity research .
|
-
- HY-101618
-
-
- HY-20019
-
|
|
PPAR
|
Metabolic Disease
|
|
L-165041 is a cell permeable PPARδ agonist, with Kis of 6 nM and appr 730 nM for PPARδ and PPARγ, respectively, and induces adipocyte differentiation in NIH-PPARδ cells.
|
-
- HY-N0455
-
|
|
NO Synthase
Endogenous Metabolite
|
Cardiovascular Disease
Cancer
|
|
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .
|
-
- HY-12787
-
|
|
Raf
Autophagy
|
Cancer
|
|
L-779450 is a potent and selective B-Raf kinase inhibitor with a Kd of 2.4 nM.
|
-
- HY-14426
-
-
- HY-18698
-
|
|
iGluR
|
Neurological Disease
|
|
L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC50=2 nM). L-701324 has antidepressant activity .
|
-
- HY-15588
-
L189
3 Publications Verification
|
DNA/RNA Synthesis
|
Cancer
|
|
L189 is a DNA ligase inhibitor. L189 has inhibition effect for DNA Ligase I, III and IV with IC50 values of 5 μM, 9 μM and 5 μM, respectively. L189 has no cytotoxicity and individually increase cell death. L189 can be used for the research of cancer .
|
-
- HY-B1000A
-
|
|
Endogenous Metabolite
Apoptosis
|
Cancer
|
|
L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium. L-SelenoMethionin is a cancer chemopreventive agent that can reduce cancer incidence by dietary supplementation and induce apoptosis of cancer cells. L-SelenoMethionine also can increase expression of glutathione peroxidase .
|
-
- HY-16273A
-
|
|
Farnesyl Transferase
|
Cancer
|
|
L-778123 hydrochloride is a dual inhibitor of FPTase and GGPTase-I, with IC50 values of 2 nM and 98 nM respectively.
|
-
- HY-U00237
-
-
- HY-U00245
-
-
- HY-U00254
-
-
- HY-U00261
-
-
- HY-19334
-
-
- HY-N0832
-
