Search Result

Targets Recommended:	PI4K MAP4K PD-1/PD-L1 Oct3/4 FXR Serotonin Transporter

Results for "4-1BB L Inhibitors" in MCE Product Catalog:

By Targets:	PD-1/PD-L1 (7) 5-HT Receptor (2) AChE (1) ADC Cytotoxin (2) ADC Linker (5) Adrenergic Receptor (15) Angiotensin Receptor (4) Antibiotic (10) Apoptosis (17) Arginase (2) Aryl Hydrocarbon Receptor (1) Autophagy (13) Bacterial (21) Bcr-Abl (1) c-Kit (1) c-Met/HGFR (1) Calcium Channel (3) CaMK (1) Carbonic Anhydrase (4) Casein Kinase (1) Cathepsin (2) CDK (2) Cholecystokinin Receptor (1) COX (4) CRISPR/Cas9 (1) CXCR (2) DNA Methyltransferase (1) DNA/RNA Synthesis (2) Dopamine Receptor (11) Drug Metabolite (3) DYRK (2) EGFR (1) Elastase (1) Endogenous Metabolite (129) Ephrin Receptor (1) Epigenetic Reader Domain (2) Factor Xa (1) Farnesyl Transferase (1) Ferroptosis (10) FLAP (1) Fungal (5) GABA Receptor (7) GLUT (1) Glutaminase (1) HBV (2) HCV (2) Histone Acetyltransferase (1) Histone Demethylase (3) Histone Methyltransferase (5) HIV (10) HIV Integrase (1) HIV Protease (3) HSV (1) iGluR (8) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (3) Integrin (2) JNK (1) Leukotriene Receptor (2) mAChR (4) MAP3K (1) Melatonin Receptor (1) mGluR (6) Microtubule/Tubulin (1) Mitochondrial Metabolism (3) MMP (2) Monoamine Oxidase (1) mTOR (1) nAChR (1) Neurokinin Receptor (6) Neuropeptide Y Receptor (1) NO Synthase (11) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (1) Oxytocin Receptor (2) p38 MAPK (2) Parasite (4) Phosphatase (7) Phosphodiesterase (PDE) (2) PI3K (1) PKA (1) PKC (1) Porcupine (1) PPAR (2) Prostaglandin Receptor (5) PROTAC (1) PROTAC Linker (6) Raf (1) Ras (1) Reactive Oxygen Species (8) Reverse Transcriptase (2) SARS-CoV (2) SGLT (2) Sodium Channel (3) Somatostatin Receptor (3) Src (1) STAT (4) Thrombin (1) Thyroid Hormone Receptor (4) TNF Receptor (1) Toll-like Receptor (TLR) (1) TRP Channel (5) Tryptophan Hydroxylase (1) Vasopressin Receptor (1) VEGFR (2) Virus Protease (2) Wnt (1) β-catenin (1) γ-secretase (1)
By Research Areas:	Cancer (122) Cardiovascular Disease (34) Endocrinology (34) Infection (47) Inflammation/Immunology (60) Metabolic Disease (88) Neurological Disease (84)

By Targets:

PD-1/PD-L1 (7)

5-HT Receptor (2)

AChE (1)

ADC Cytotoxin (2)

ADC Linker (5)

Adrenergic Receptor (15)

Angiotensin Receptor (4)

Antibiotic (10)

Apoptosis (17)

Arginase (2)

Aryl Hydrocarbon Receptor (1)

Autophagy (13)

Bacterial (21)

Bcr-Abl (1)

c-Kit (1)

c-Met/HGFR (1)

Calcium Channel (3)

CaMK (1)

Carbonic Anhydrase (4)

Casein Kinase (1)

Cathepsin (2)

CDK (2)

Cholecystokinin Receptor (1)

COX (4)

CRISPR/Cas9 (1)

CXCR (2)

DNA Methyltransferase (1)

DNA/RNA Synthesis (2)

Dopamine Receptor (11)

Drug Metabolite (3)

DYRK (2)

EGFR (1)

Elastase (1)

Endogenous Metabolite (129)

Ephrin Receptor (1)

Epigenetic Reader Domain (2)

Factor Xa (1)

Farnesyl Transferase (1)

Ferroptosis (10)

FLAP (1)

Fungal (5)

GABA Receptor (7)

GLUT (1)

Glutaminase (1)

HBV (2)

HCV (2)

Histone Acetyltransferase (1)

Histone Demethylase (3)

Histone Methyltransferase (5)

HIV (10)

HIV Integrase (1)

HIV Protease (3)

HSV (1)

iGluR (8)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Influenza Virus (3)

Integrin (2)

JNK (1)

Leukotriene Receptor (2)

mAChR (4)

MAP3K (1)

Melatonin Receptor (1)

mGluR (6)

Microtubule/Tubulin (1)

Mitochondrial Metabolism (3)

MMP (2)

Monoamine Oxidase (1)

mTOR (1)

nAChR (1)

Neurokinin Receptor (6)

Neuropeptide Y Receptor (1)

NO Synthase (11)

Nucleoside Antimetabolite/Analog (1)

Opioid Receptor (1)

Oxytocin Receptor (2)

p38 MAPK (2)

Parasite (4)

Phosphatase (7)

Phosphodiesterase (PDE) (2)

PI3K (1)

PKA (1)

PKC (1)

Porcupine (1)

PPAR (2)

Prostaglandin Receptor (5)

PROTAC (1)

PROTAC Linker (6)

Raf (1)

Ras (1)

Reactive Oxygen Species (8)

Reverse Transcriptase (2)

SARS-CoV (2)

SGLT (2)

Sodium Channel (3)

Somatostatin Receptor (3)

Src (1)

STAT (4)

Thrombin (1)

Thyroid Hormone Receptor (4)

TNF Receptor (1)

Toll-like Receptor (TLR) (1)

TRP Channel (5)

Tryptophan Hydroxylase (1)

Vasopressin Receptor (1)

VEGFR (2)

Virus Protease (2)

Wnt (1)

β-catenin (1)

γ-secretase (1)

By Research Areas:

Cancer (122)

Cardiovascular Disease (34)

Endocrinology (34)

Infection (47)

Inflammation/Immunology (60)

Metabolic Disease (88)

Neurological Disease (84)

424

Inhibitors & Agonists

Dye Reagents

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

179

Natural
Products

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas

HY-U00439

Protein kinase inhibitors 1
DYRK Cancer

Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC₅₀ of 74 nM and K_d of 9.5 nM.
HY-N2596

Isoscabertopin
Others Cancer Inflammation/Immunology

Isoscabertopin is a sesquiterpene lactone isolated from Elephantopus scaber L and shows anti-tumor activities.
HY-131005

Ehp inhibitor 2
Ephrin Receptor Cancer

Ehp inhibitor 2 is a Eph family tyrosine kinase inhibitor.
HY-121879

SHP836
Phosphatase Cancer

SHP836 is a SHP2 allosteric inhibitor, with an IC₅₀ of 12 μM for the full length SHP2.

*Protein kinase inhibitors* 1**	DYRK	Cancer
Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC₅₀ of 74 nM and K_d of 9.5 nM.

Isoscabertopin	Others	Cancer Inflammation/Immunology
Isoscabertopin is a sesquiterpene lactone isolated from Elephantopus scaber L and shows anti-tumor activities.

Ehp inhibitor 2	Ephrin Receptor	Cancer
Ehp inhibitor 2 is a Eph family tyrosine kinase inhibitor.

SHP836	Phosphatase	Cancer
SHP836 is a SHP2 allosteric inhibitor, with an IC₅₀ of 12 μM for the full length SHP2.

HY-N2905

Aurantiamide acetate Asperglaucide	Cathepsin	Inflammation/Immunology
Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases.

HY-19373

RWJ-445167 3DP-10017	Thrombin Factor Xa	Cardiovascular Disease
RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with K_i of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

HY-16787

ICA-121431	Sodium Channel	Cardiovascular Disease
ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Na_v) blocker, shows equipotent selectivity for human Na_v1.1 and Na_v1.3 subtypes with IC₅₀ values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Na_v1.2 (IC₅₀=240 nM) and 1,000 fold selectivity against Na_v1.4, Na_v1.6, and the TTX-resistant human Na_v1.5 and Na_v1.8 channels (IC₅₀s >10 µM).

HY-U00439A

*Protein kinase inhibitors* 1 hydrochloride** (E)-5-((2-Oxo-6'-(piperazin-1-yl)-1,2-dihydro-[3,3'-bipyridin]-5-yl)methylene)thiazolidine-2,4-dione hydrochloride	DYRK	Cancer
Protein kinase inhibitors 1 hydrochloride is a potent HIPK2 inhibitor, with IC₅₀s of 136 and 74 nM for HIPK1 and HIPK2, and a K_d of 9.5 nM for HIPK2.

HY-W012037

8-Hydroxyquinoline hemisulfate 8-Quinolinol hemisulfate	Bacterial Antibiotic	Infection
8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.

HY-B0744C

L-Eflornithine L-DFMO; L-RMI71782; L-α-difluoromethylornithine	Others	Cancer
L-Eflornithine (L-DFMO) is an enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a K_D of 1.3±0.3 µM, and a K_inact of 0.15±0.03 min^-1.

HY-128434

L-Leucyl-L-alanine
Endogenous Metabolite Metabolic Disease

L-Leucyl-L-alanine is a simple dipeptide composed of L-leucine and L-alanine.
HY-W010042

L-Glucose
L-(-)-Glucose
Others Metabolic Disease

L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose can promote food intake.

L-Leucyl-L-alanine	Endogenous Metabolite	Metabolic Disease
L-Leucyl-L-alanine is a simple dipeptide composed of L-leucine and L-alanine.

L-Glucose L-(-)-Glucose	Others	Metabolic Disease
L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose can promote food intake.

HY-W014102

L-Alanyl-L-glutamine	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations.

HY-107734

L 152804	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a K_i of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.

HY-111271

L 888607
Prostaglandin Receptor Inflammation/Immunology Endocrinology

L 888607 is a potent, and selective CRTH2 (also known as DP₂) agonist with a K_i of 0.8 nM.
HY-101125

L-45
L-Moses
Epigenetic Reader Domain Cancer

L-45 is the first potent, selective, and cell-active p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor with a K_d of 126±15 nM.

L 888607	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
L 888607 is a potent, and selective CRTH2 (also known as DP₂) agonist with a K_i of 0.8 nM.

L-45 L-Moses	Epigenetic Reader Domain	Cancer
L-45 is the first potent, selective, and cell-active p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor with a K_d of 126±15 nM.

HY-101552B

L,L-Dityrosine hydrochloride	Others	Others
L,L-Dityrosine (hydrochloride) is a constituent of acid hydrolysates of a number of biological materials, including the insect cuticular resilin.

HY-A0282

L-Ornithine L-aspartate	Others	Metabolic Disease
L-Ornithine L-aspartate is a stable salt of two natural nonessential L-amino acids: ornithine and aspartic acid. L-Ornithine L-aspartate lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis.

HY-78139

L-Xylose
L-(-)-Xylose
Others Others

L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type.

L-Xylose L-(-)-Xylose	Others	Others
L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type.

HY-101125A

L-45 dihydrochloride L-Moses dihydrochloride	Epigenetic Reader Domain	Cancer
L-45 dihydrochloride (L-Moses dihydrochloride) is the first potent, selective, and cell-active p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor with a K_d of 126±15 nM.

HY-135813

LtaS-IN-1	Bacterial	Infection
LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely.

HY-125957

A-3 hydrochloride	PKA Casein Kinase CaMK PKC	Others
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (K_i=4.3 µM), casein kinase II (K_i=5.1 µM) and myosin light chain kinase (MLCK) (K_i=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with K_i values of 47 µM and 80 µM, respectively.

HY-100781A

L-APB L-AP 4	mGluR	Neurological Disease
L-APB is a potent and specific agonist for the group III mGluRs, with EC₅₀s of 0.13, 0.29, 1.0, 249 μM for mGlu₄, mGlu₈, mGlu₆ and mGlu₇ receptors, respectively.

HY-N1436

L-(+)-Abrine L-Abrine; L-N-Methyltryptophan; N-α-Methyl-L-tryptophan	Others	Inflammation/Immunology
L-(+)-Abrine, a lethal albumin found in Abrus precatorius seeds, is an acute toxic alkaloid and chemical marker for abrin.

HY-112171

γ-L-Glutamyl-L-alanine
Endogenous Metabolite Others

γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is a proteolytic breakdown product of larger proteins.

*γ-L-Glutamyl-L-alanine*	Endogenous Metabolite	Others
γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is a proteolytic breakdown product of larger proteins.

HY-19369

L-685458 L-685,458	γ-secretase Apoptosis	Neurological Disease Cancer
L-685458 is a potent inhibitor of Amyloid β-Protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested.

HY-111271A

L 888607 Racemate	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
L 888607 Racemate is a selective prostaglandin D₂ receptor subtype 1 (DP1) antagonist, with K_is of 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respectively.

HY-101590

Symetine
L 16726
Parasite Infection

Symetine is an antiparasitic and antispirochete agent.

Symetine L 16726	Parasite	Infection
Symetine is an antiparasitic and antispirochete agent.

HY-101918

DS-1040 Tosylate	Others	Cardiovascular Disease
DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC₅₀s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases.

HY-18728

STF-31
GLUT Autophagy Cancer

STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC₅₀ of 1μM^[1][2].

STF-31	GLUT Autophagy	Cancer
STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC₅₀ of 1μM^[1][2].

HY-B0744D

L-Eflornithine monohydrochloride L-DFMO monohydrochloride; L-RMI71782 monohydrochloride; L-α-difluoromethylornithine monohydrochloride	Others	Cancer
L-Eflornithine monohydrochloride (L-DFMO monohydrochloride) is an enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a K_D of 1.3±0.3 µM, and a K_inact of 0.15±0.03 min^-1.

HY-D0187

L-Glutathione reduced GSH; γ-L-Glutamyl-L-cysteinyl-glycine	Endogenous Metabolite Reactive Oxygen Species Ferroptosis	Cancer Inflammation/Immunology Neurological Disease Cardiovascular Disease
L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.

HY-15129

O-Phospho-L-serine L-Serine O-phosphate; L-SOP	mGluR Endogenous Metabolite	Neurological Disease
O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.

HY-Y0293

L-Tartaric acid
L-(+)-Tartaric acid
Endogenous Metabolite Metabolic Disease

L-Tartaric acid (L-(+)-Tartaric acid) is an endogenous metabolite.

L-Tartaric acid L-(+)-Tartaric acid	Endogenous Metabolite	Metabolic Disease
L-Tartaric acid (L-(+)-Tartaric acid) is an endogenous metabolite.

HY-N0229

L-Alanine L-2-Aminopropionic acid	Endogenous Metabolite	Metabolic Disease Neurological Disease
L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.

HY-N6960

L-Stepholidine Stepholidine; (-)-Stepholidine; L-SPD	Dopamine Receptor	Neurological Disease
L-Stepholidine (Stepholidine), an alkaloid extract of the Chinese herb Stephania intermedia, is the first compound known to exhibit mixed dopamine D1 receptor agonist/D2 antagonist properties. L-Stepholidine (Stepholidine) has neuroprotective effect and inhibits heroin-induced reinstatement. L-Stepholidine (Stepholidine) is a potential medication for the treatment of opiate addiction.

HY-101552A

L,L-Dityrosine
o,o'-Dityrosine
Others Others

L,L-Dityrosine is a constituent of acid hydrolysates of a number of biological materials, including the insect cuticular resilin.

L,L-Dityrosine o,o'-Dityrosine	Others	Others
L,L-Dityrosine is a constituent of acid hydrolysates of a number of biological materials, including the insect cuticular resilin.

HY-14166

MK-886 L 663536	FLAP Leukotriene Receptor PPAR Apoptosis	Cancer
MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC₅₀ of 30 nM) and leukotriene biosynthesis (IC₅₀s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis.

HY-104011

L-Pyrrolysine
Others Others

L-Pyrrolysine is the 22nd genetically encoded amino acid.

L-Pyrrolysine	Others	Others
L-Pyrrolysine is the 22nd genetically encoded amino acid.

HY-14325

L-745870	Dopamine Receptor	Neurological Disease
L-745870 is a potent, selective, brain-penetrant and orally active dopamine D₄ receptor antagonist with a K_i of 0.43 nM. L-745870 shows weaker affinity for D₂ (K_i of 960 nM) and D₃ (K_i of 2300 nM) receptors, and exhibits moderate affinity for 5-HT₂ receptors, sigma sites and α-adrenoceptors.

HY-128394

L-Gulose
Others Metabolic Disease

L-Gulose, the putative furanose form of L-sorbosone, is an L-hexose sugar and an intermediate in the biosynthesis of L-Ascorbate (vitamin C).

L-Gulose	Others	Metabolic Disease
L-Gulose, the putative furanose form of L-sorbosone, is an L-hexose sugar and an intermediate in the biosynthesis of L-Ascorbate (vitamin C).

HY-119163

L-902688	Prostaglandin Receptor	Inflammation/Immunology Cardiovascular Disease
L-902688 is a potent, selective and orally active EP4 receptor agonist with a K_i of 0.38 nM and an EC₅₀ of 0.6 nM. L-902688 shows >4,000-fold selective for EP4 over other EP and prostanoid receptors.

HY-101075

L-690330	Phosphatase	Others
L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with K_is of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 exhibits 10-fold more sensitive than mouse and rat IMPase.

HY-100671

L002	Histone Acetyltransferase STAT	Cancer Inflammation/Immunology
L002 is a potent, cell permeable, reversible and specific acetyltransferase p300 (KAT3B) inhibitor with an IC₅₀ of 1.98 μM. L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 activation. L002 has the potential for hypertension‐induced cardiac hypertrophy and fibrogenesis treatment.

HY-19334

L755507
Adrenergic Receptor CRISPR/Cas9 Cancer Endocrinology

L755507 is a potent, selective agonist of β₃-AR with an IC₅₀ of 35 nM.

L755507	Adrenergic Receptor CRISPR/Cas9	Cancer Endocrinology
L755507 is a potent, selective agonist of β₃-AR with an IC₅₀ of 35 nM.

HY-101348

L-741626	Dopamine Receptor	Neurological Disease
L-741626 is a selective D2 dopamine receptor antagonist, with the K_i values of 2.4, 100 and 220 nM for human D2, D3 and D4 receptors respectively.

HY-18698

L-701324
iGluR Neurological Disease

L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.
HY-113144

L-Hexanoylcarnitine
Endogenous Metabolite Metabolic Disease

L-Hexanoylcarnitine is an acylcarnitine and is found to be associated with celiac disease.

L-701324	iGluR	Neurological Disease
L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.

HY-N0391

L-Citrulline	Endogenous Metabolite	Others
L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.

HY-101249

L-732138	Neurokinin Receptor	Cancer Neurological Disease
L-732138 is a selective, potent and competitive neurokinin-1 (NK-1) receptor antagonist with an IC₅₀ of 2.3 nM. L-732138 has 200-fold more potent in cloned human NK-1 receptors than cloned rat NK-1 receptors, and has > 1000-fold more potent than human NK-2 and NK-3 receptors. L-732138 can reduce hyperalgesia and has antitumor action.

HY-100986

L-NIO dihydrochloride	NO Synthase	Cardiovascular Disease
L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with K_is of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively. L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats.

HY-W015611

L-(+)-Arabinose	Endogenous Metabolite	Metabolic Disease
L-(+)-Arabinose selectively inhibits intestinal sucrase activity in a noncompetitive manner and suppresses the plasma glucose increase due to sucrose ingestion.

HY-20019

L-165041	PPAR	Metabolic Disease
L-165041 is a cell permeable PPARδ agonist, with K_is of 6 nM and appr 730 nM for PPARδ and PPARγ, respectively, and induces adipocyte differentiation in NIH-PPARδ cells.

HY-12116

L-NIL
NO Synthase Inflammation/Immunology

L-NIL is an inducible NO synthase inhibitor, with an IC₅₀ of 3.3 μM for miNOS.
HY-W009749

L-Cystathionine
Endogenous Metabolite Others

L-Cystathionine is a key nonprotein amino acid related to metabolic conditions.
HY-U00245

L162441
Angiotensin Receptor Metabolic Disease Endocrinology

L162441 is an Angiotensin type 1 receptor antagonist.
HY-40135

L-Hydroxyproline
Endogenous Metabolite Others

L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.
HY-140346

L-Azidohomoalanine
PROTAC Linker Cancer

L-Azidohomoalanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-N0473

L-Tyrosine
Endogenous Metabolite Neurological Disease

L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
HY-15588

L189
DNA/RNA Synthesis Cancer

L189 is a novel human DNA ligase inhibitor, inhibits hLigI/III/IV with IC50 of 5/9/5 μM.
HY-B1000A

L-SelenoMethionine
Endogenous Metabolite Apoptosis Cancer

L-SelenoMethionine is a major natural food-form of selenium.
HY-N0771

L-Isoleucine
Endogenous Metabolite Others

L-isoleucine is a nonpolar hydrophobic amino acid. L-Isoleucine is an essential amino acid.

HY-108559

L-161982	Prostaglandin Receptor	Inflammation/Immunology
L-161982 is a selective EP4 receptor antagonist. L-161982 completely blocks PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 alleviates collagen-induced arthritis in mice.

HY-113161

L-Octanoylcarnitine
Endogenous Metabolite Metabolic Disease

L-Octanoylcarnitine is the physiologically active form of octanoylcarnitine.

HY-N2375

L-Quebrachitol	Wnt β-catenin	Metabolic Disease
L-Quebrachitol is a natural product isolated from many plants, promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway.

HY-W010347

L-Homocysteine	Endogenous Metabolite	Inflammation/Immunology
L-Homocysteine, a homocysteine metabolite, is a homocysteine that has L configuration. L-Homocysteine induces upregulation of cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia.

HY-N0717

L-Valine
Endogenous Metabolite Others

L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid.

HY-W013494

L-Carnosine	Endogenous Metabolite	Metabolic Disease
L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging.

HY-Y0337

L-Cysteine
Endogenous Metabolite Ferroptosis Metabolic Disease

L-Cysteine is a thiol-containing non-essential amino acid that is oxidized to form cystine.

HY-101076

L-690488	Phosphatase	Metabolic Disease
L-690488 is a prodrug of L-690330 and is a selective inositol monophosphatase (IMPase) inhibitor. L-690488 has more effective cell penetration than L-690330.

HY-104026

L-Kynurenine	Aryl Hydrocarbon Receptor Endogenous Metabolite	Cancer Inflammation/Immunology Neurological Disease Cardiovascular Disease
L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.

HY-U00261

L-689502
HIV Protease Inflammation/Immunology

L-689502 is a potent inhibitor of HIV-l protease with an IC₅₀ of 1 nM.
HY-113147

L-Palmitoylcarnitine
Endogenous Metabolite Metabolic Disease

L-Palmitoylcarnitine is a fatty acid metabolite.

HY-101385

L-765314	Adrenergic Receptor	Cardiovascular Disease Endocrinology
L-765314 is a potent and selective α1b adrenergic receptor antagonist with K_is of 5.4 nM and 2.0 nM for rat and human α1b adrenergic receptor, respectively.

HY-12118

L-NIL dihydrochloride
NO Synthase Inflammation/Immunology

L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC₅₀ of 3.3 μM for miNOS.
HY-N0486

L-Leucine
mTOR Metabolic Disease

L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
HY-Y0399

L-Norvaline
Endogenous Metabolite Metabolic Disease

L-Norvaline is an endogenous metabolite.
HY-U00254

L791943
Phosphodiesterase (PDE) Neurological Disease

L791943 is a potent, selective Phosphodiesterase-4 (PDE4) inhibitor with an IC₅₀ of 4.2 nM.
HY-N0394

L-Cystine
Endogenous Metabolite Ferroptosis Others

L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes.

HY-N0832

L-Histidine	Mitochondrial Metabolism Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Neurological Disease
L-Histidine is an essential amino acid for infants. L-Histidine is an inhibitor of mitochondrial glutamine transport.

HY-108497

L-803087	Somatostatin Receptor	Cancer Neurological Disease
L-803087 is a potent and selective somatostatin sst4 receptor agonist with a K_i of 0.7 nM. L-803087 is >280-fold higher than other somatostatin receptors. L-803087 facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice.

HY-Y0252

L-Proline
Endogenous Metabolite Others

L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.

HY-W018004

L-Homocitrulline	Endogenous Metabolite	Metabolic Disease
L-Homocitrulline is metabolized to homoarginine through homoargininosuccinate via the urea cycle pathway and its metabolic abnormality could lead to Lysinuric Protein Intolerance (LPI).

HY-W002292

L-Homoserine
Endogenous Metabolite Others

L-Homoserine is a non - protein amino acid, which is an important biosynthetic intermediate of threonine, methionine and lysine.
HY-14426

L-655708
GABA Receptor Neurological Disease

L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (K_i=0.45 nM).

HY-W040141

L-Arabinitol	Endogenous Metabolite	Metabolic Disease
L-Arabinitol is a potential biomarker for the comsuption of the food products such as sweet potato, deerberry, moth bean, and is also associated with Alzheimer's disease and ribose-5-phosphate isomerase deficiency.

HY-101178

L-689560	iGluR	Neurological Disease
L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases.

HY-N0658

L-Threonine
Endogenous Metabolite Others

L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed.
HY-WAA0142

L-Prolylglycine
Endogenous Metabolite Metabolic Disease

L-Prolylglycine is an endogenous metabolite.
HY-101618

L162389
Angiotensin Receptor Cardiovascular Disease

L162389 is a potent antagonist of angiotensin AT1 receptor with K_i of 28 nM.

HY-50887

L-873724	Cathepsin	Metabolic Disease
L-873724 is a potent, orally bioavailable, selective and reversible non-basic cathepsin K inhibitor, with IC₅₀s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively. L-873724 also exhibits an IC₅₀ of 0.5 nM for rabbit cathepsin K. L-873724 inhibits bone resorption.

HY-U00237

L-771688
Adrenergic Receptor Cancer Endocrinology

L-771688 is a highly selective α1A-Adrenoceptor antagonist with a K_i of 0.43±0.02 nM.

HY-W011690

L-Homocystine	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Cardiovascular Disease
L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.

HY-129476

L-Canaline	Parasite Endogenous Metabolite	Cancer Infection
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite *Plasmodium falciparum* with an IC₅₀ of 297 nM. L-Canaline has anticancer and antiproliferative effects.

HY-140345

L-Homopropargylglycine
PROTAC Linker Cancer

L-Homopropargylglycine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-N0326

L-Methionine
Endogenous Metabolite Others

L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
HY-12787

L-779450
Raf Autophagy Cancer

L-779450 is a potent and selective B-Raf kinase inhibitor with a K_d of 2.4 nM.

HY-N0469

L-Lysine	Endogenous Metabolite Virus Protease	Inflammation/Immunology
L-lysine is an essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions.

HY-13735C

l-Atabrine dihydrochloride
Bacterial Infection

l-Atabrine dihydrochloride is a less active enantiomer of quinacrine which displays antiprion activity.
HY-W014233

L-Histidinol dihydrochloride
Endogenous Metabolite Metabolic Disease

L-Histidinol dihydrochloride is an endogenous metabolite.

HY-107373

β-Chloro-L-alanine L-β-Chloroalanine	Bacterial	Infection
β-Chloro-L-alanine is a bacteriostatic amino acid analog which inhibits a number of enzymes, including threonine deaminase and alanine racemase.

HY-101414

L-DABA L-2,4-Diaminobutyric acid	GABA Receptor Endogenous Metabolite	Neurological Disease Cancer
L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC₅₀ of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

HY-B0166

L-Ascorbic acid
L-Ascorbate; Vitamin C
Reactive Oxygen Species Apoptosis Metabolic Disease

L-Ascorbic acid is an effective reducing agent and donor antioxidant.

HY-B1716

L-5-Hydroxytryptophan L-5-HTP; Oxitriptan	Endogenous Metabolite	Metabolic Disease Neurological Disease
L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia.

HY-B2188

S-Methyl-L-cysteine L-S-Methylcysteine	Reactive Oxygen Species	Metabolic Disease Neurological Disease
S-Methyl-L-cysteine is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities.

HY-16273A

L-778123 hydrochloride L-778,123 hydrochloride	Farnesyl Transferase	Cancer
L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.

HY-N0666C

L-Aspartic aicd sodium
Sodium L-aspartate
Endogenous Metabolite Others

L-Aspartic aicd sodium is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

HY-N0390

L-Glutamine L-Glutamic acid 5-amide	mGluR Endogenous Metabolite Ferroptosis	Metabolic Disease
L-Glutamine is a non-essential amino acid present abundantly throughout the body and is involved in gastrointestinal disorders.

HY-100385

Brevianamide F Cyclo(L-Pro-L-Trp)	PI3K Bacterial	Infection
Brevianamide F (Cyclo(L-Pro-L-Trp)) is a mycotoxin isolated from Colletotrichum gloeosporioides, with antibacterial activity. Brevianamide F shows potent PI3Kα inhibitory activity with an IC₅₀ of 4.8 µM.

HY-N1480

(-)-Fucose 6-Desoxygalactose; L-(-)-Fucose; L-Galactomethylose	Endogenous Metabolite Parasite	Infection Metabolic Disease
(-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interactions.

HY-15583

Auristatin F	Microtubule/Tubulin ADC Cytotoxin	Cancer
Auristatin F is a potent cytotoxin. Auristatin F, a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (ADC).

HY-15121

L-Theanine L-Glutamic Acid γ-ethyl amide; Nγ-Ethyl-L-glutamine	Apoptosis	Neurological Disease
L-Theanine (L-Glutamic Acid γ-ethyl amide）is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective and anti-oxidative activities. L-Theanine causes anti-stress effects via the inhibition of cortical neuron excitation by oral intake.

HY-16743A

Ibiglustat L-Malic acid Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid)	Others	Metabolic Disease
Ibiglustat L-Malic acid (Venglustat L-Malic acid), a potential therapy for PD Parkinson’s disease, SRT in Fabry’s and Gaucher’s, is a selective, allosteric inhibitor of glucosylceramide synthase (GCS) with ability to cross the blood-brain barrier.

HY-106376A

L-Buthionine-(S,R)-sulfoximine L-Buthionine sulfoximine	Ferroptosis	Cancer
L-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC₅₀ value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.

HY-118100

Cyclo(Tyr-Val)
Cyclo(L-Tyr-L-Val)
Drug Metabolite

Cyclo(Tyr-Val) (Cyclo(L-Tyr-L-Val)) is a diketopiperazine secondary fungal metabolite originally isolated from N. gilva.
HY-W040088

L-Alanyl-L-leucine
H-Ala-Leu-OH
Endogenous Metabolite Metabolic Disease

L-Alanyl-L-leucine is an endogenous metabolite.

HY-79136

Pasireotide L-aspartate salt SOM230 L-aspartate	Somatostatin Receptor	Cancer Endocrinology
Pasireotide(SOM 230) is a stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9 respectively).

HY-15252

Reparixin L-lysine salt Repertaxin L-lysine salt	CXCR	Cancer Inflammation/Immunology Endocrinology
Reparixin L-lysine salt is an allosteric inhibitor of chemokine receptor 1/2 (CXCR1/2) activation.

HY-125773

β-cyano-L-Alanine Beta-cyano-l-alanine	Others	Neurological Disease
β-cyano-L-Alanine (Beta-cyano-l-alanine), a nitrile of widespread occurrence in higher plants, is enzymatically produced by cyanoalanine synthase from cyanide and cysteine as substrates. β-cyano-L-Alanine abolishes the protective effect of ethanol on cerebral ischemia/reperfusion (I/R) injury.

HY-N1914

Ergothioneine L-(+)-Ergothioneine	Endogenous Metabolite	Others
Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant.

HY-P0069A

L-JNKI-1
JNK Neurological Disease

L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK.

HY-70053A

Fesoterodine L-mandelate	mAChR	Metabolic Disease Neurological Disease
Fesoterodine L-mandelate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pK_i values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine L-mandelate is used for the overactive bladder (OAB).

HY-W009208

Calcium L-Threonate	Endogenous Metabolite	Metabolic Disease
Calcium L-Threonate is an anti-osteoporosis agent, and widely used as a calcium supplement. Calcium L-Threonate also stimulates the uptake of ascorbic acid.

HY-N1368B

(-)-Borneol
L-Borneol
GABA Receptor Neurological Disease

(-)-Borneol has a highly efficacious positive modulating action at GABA receptor with an EC₅₀ of 237 μM.
HY-B0399

L-Carnitine
Levocarnitine
Endogenous Metabolite Metabolic Disease

L-carnitine (Levocarnitine) is constituent of striated muscle and liver.

HY-N1420

Rhamnose L-Rhamnose	Endogenous Metabolite	Cancer
Rhamnose (L-Rhamnose) is a monosaccharide found in plants and bacteria. Rhamnose-conjugated immunogens is used in immunotherapies. Rhamnose crosses the epithelia via the transcellular pathway and acts as a marker of intestinal absorption.

HY-W016077

Glycyl-L-leucine
Others Others

Glycyl-l-leucine is a dipeptide that can be a common substrate for glycyl-leucine dipeptidase.
HY-W011393

L-Anserine nitrate
Endogenous Metabolite Metabolic Disease

L-Anserine nitrate is an endogenous metabolite.

HY-W017018

L-Ornithine hydrochloride	Endogenous Metabolite	Metabolic Disease
L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.

HY-W009749B

D,L-Cystathionine dihydrochloride	Others	Others
D,L-Cystathionine dihydrochloride is an intermediate in the synthesis of cysteine that is produced from homocysteine and serine by the action of cystathionine-β-synthase (CBS). DL-Cystathionine contains a carbon-sulfide bond of cystathionine (βC-S) linkage.

HY-114626

L-Lysine thioctate
Others Others

L-Lysine thioctate is a substrate of lipoamidase.
HY-W016785

Glycyl-L-valine
Endogenous Metabolite Others

Glycyl-L-valine is a dipeptide that contains glycine and valine.

HY-14325A

L-745870 trihydrochloride	Dopamine Receptor	Neurological Disease
L-745870 trihydrochloride is a potent, selective, brain-penetrant and orally active dopamine D₄ receptor antagonist with a K_i of 0.43 nM. L-745870 trihydrochloride shows weaker affinity for D₂ (K_i of 960 nM) and D₃ (K_i of 2300 nM) receptors, and exhibits moderate affinity for 5-HT₂ receptors, sigma sites and α-adrenoceptors.

HY-W017443

L-Asparagine monohydrate	Endogenous Metabolite	Metabolic Disease
L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-W016443

L-m-Tyrosine	Others	Inflammation/Immunology Neurological Disease
L-m-Tyrosine is an unnatural amino acid, that has potential in the research of Parkinsons disease, Alzheimers disease, and arthritis.

HY-76082

L-Pyroglutamic acid	Endogenous Metabolite	Others
L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.

HY-B0553

Methazolamide
L584601
Carbonic Anhydrase Others

Methazolamide is a carbonic anhydrase inhibitor used to treat glaucoma.
HY-B1581A

L-Canavanine sulfate
NO Synthase Cancer

L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.

HY-100804

L-Cysteinesulfinic acid	mGluR Endogenous Metabolite	Neurological Disease
L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.

HY-I1196

Sofosbuvir impurity L	HCV	Infection
Sofosbuvir impurity L, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-19333

OG-L002	Histone Demethylase Monoamine Oxidase HSV	Infection
OG-L002 is a potent and highly selective LSD1 inhibitor with an IC₅₀ of 0.02 μM. OG-L002 is a potent monoamine oxidases (MAO) inhibitor with IC₅₀s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IE genes.

HY-113377

L-Glyceric acid	Endogenous Metabolite	Metabolic Disease
L-Glyceric acid is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid excretion to distinguish PH1 from PH2.

HY-N0471

L-Hyoscyamine
Daturine
mAChR Neurological Disease

L-Hyoscyamine is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine.
HY-W015495

L-Dihydroorotic acid
Endogenous Metabolite Others

L-Dihydroorotic acid can reversibly hydrolyze to yield the acyclic L-ureidosuccinic acid by dihydrowhey enzyme.

HY-113165

Isobutyryl-L-carnitine	Endogenous Metabolite	Metabolic Disease
Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases. Isobutyryl-L-carnitine is a member of the class of compounds known as acyl carnitines.

HY-14406A

L-733060 hydrochloride	Neurokinin Receptor	Cancer Neurological Disease
L-733060 hydrochloride is a potent tachykinin NK₁ receptor antagonist. L-733060 hydrochloride inhibits neurogenic plasma extravasation at doses that do not cause adverse cardiovascular effects in rodents and also acts as an antitumoral agent.

HY-N0666

L-Aspartic acid
Endogenous Metabolite Cardiovascular Disease

L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

HY-N2573

Corydalmine L-Corydalmine	Fungal CXCR	Infection Neurological Disease
Corydalmine (L-Corydalmine), an alkaloid isolated from roots of Corydalis Chaerophylla, inhibits spore germination of some plant pathogenic as well as saprophytic fungi. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway.

HY-14894A

Ipragliflozin L-Proline	SGLT	Metabolic Disease
Ipragliflozin (L-Proline) is a highly potent and selective SGLT2 inhibitor with an IC₅₀ of 2.8 nM; little and NO potency for SGLT1/3/4/5/6.

HY-15010

L-371,257	Oxytocin Receptor Vasopressin Receptor	Endocrinology
L-371,257 is an orally bioavailable, non-blood-brain barrier penetrant, selective and competitive antagonist of oxytocin receptor (pA2=8.4) with high affinity at both the oxytocin receptor (K_i=19 nM) and vasopressin V1a receptor (K_i=3.7 nM).

HY-126085

(±)-Alliin
(±)-L-Alliin
SARS-CoV Infection

(±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of SARS-CoV-2 (M_pro).

HY-14407

Fosaprepitant L-758298	Neurokinin Receptor	Neurological Disease Endocrinology
Fosaprepitant (L-758298) is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting.

HY-Y0337A

L-Cysteine hydrochloride	Endogenous Metabolite	Metabolic Disease
L-Cysteine hydrochloride is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents and humans.

HY-14325B

L-745870 hydrochloride	Dopamine Receptor	Neurological Disease
L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D₄ receptor antagonist with a K_i of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D₂ (K_i of 960 nM) and D₃ (K_i of 2300 nM) receptors, and exhibits moderate affinity for 5-HT₂ receptors, sigma sites and α-adrenoceptors.

HY-N0470

L-Lysine hydrochloride	Virus Protease	Infection Endocrinology Inflammation/Immunology Cardiovascular Disease
L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

HY-15683

IDO5L
Indoleamine 2,3-Dioxygenase (IDO) Cancer

IDO5L is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC₅₀ of 67 nM.

HY-19217

Thioflosulide L-745337	COX	Inflammation/Immunology
Thioflosulide (L-745337) is a selective cyclooxygenase-2 (COX2) inhibitor, with an IC₅₀ of 2.3 nM, and shows anti-inflammatory activity.

HY-112234

L-Sepiapterin Sepiapterin	Endogenous Metabolite	Cancer
L-Sepiapterin (Sepiapterin) is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70^S6K-dependent VEGFR-2 expression.

HY-N1765

L-Praziquanamine
(+)-Praziquanamine
Others Others

L-Praziquanamine is a natural product.

HY-128358

MR-L2	Phosphodiesterase (PDE)	Neurological Disease
MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC₅₀ of 1.2 µM.

HY-140346A

L-Azidohomoalanine hydrochloride
PROTAC Linker Cancer

L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-W048838

Acetyl-L-lysine
Endogenous Metabolite Metabolic Disease

Acetyl-L-lysine is an endogenous metabolite.

HY-B2165

Bendazac L-Lysine	Others	Others
Bendazac L-Lysine is one of agents that have been introduced for the management of cataracts, protecting the level of vision in patients, thus delaying the need for surgical intervention.

HY-108497A

L-803087 TFA	Somatostatin Receptor	Cancer Neurological Disease
L-803087 TFA is a potent and selective somatostatin sst4 receptor agonist with a K_i of 0.7 nM. L-803087 TFA is >280-fold more selective for sst4 receptor than other somatostatin receptors. L-803087 TFA facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice.

HY-122470

Stampidine	Reverse Transcriptase HIV	Infection
Stampidine is a nucleoside reverse transcriptase inhibitor (NRTI) with potent and broad-spectrum anti-HIV activity. Stampidine inhibits the laboratory HIV-1 strain HTLV_IIIB (B-envelope subtype) and primary clinical isolates with IC₅₀s of 1 nM and 2 nM, respectively. Stampidine also inhibits NRTI-resistant primary clinical isolates and NNRTI-resistant clinical isolates with IC₅₀s of 8.7 nM and 11.2 nM, respectively.

HY-101427

Bamaquimast
F 10126; L 0042
Others Inflammation/Immunology

Bamaquimast (F 10126; L 0042) is a potent antiasthmatic drug.

HY-17038B

Agomelatine (L(+)-Tartaric acid) S-20098 L(+)-Tartaric acid	Melatonin Receptor 5-HT Receptor	Neurological Disease
Agomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine L(+)-Tartaric acid is a selective 5-HT2C receptor antagonist with pK_is of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively.

HY-W012161

Alanylphenylalanine
L-Alanyl-L-phenylalanine; H-Ala-Phe-OH
Endogenous Metabolite Metabolic Disease

Alanylphenylalanine is an endogenous metabolite.

HY-15461A

Ertugliflozin L-pyroglutamic acid PF-04971729 L-pyroglutamic acid	SGLT	Metabolic Disease
Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC₅₀ of 0.877 nM for h-SGLT2. Has the potential for the treatment of type 2 diabetes mellitus.

HY-102062

Nω-Propyl-L-arginine N-omega-Propyl-L-arginine	NO Synthase	Neurological Disease
Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a K_i of 57 nM. Nω-Propyl-L-arginine displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS).

HY-107378

L-Valyl-L-phenylalanine Valylphenylalanine; H-VAL-PHE-OH	Endogenous Metabolite	Inflammation/Immunology
L-Valyl-L-phenylalanine (Valylphenylalanine; H-VAL-PHE-OH) has been reported as biocompatible polymer.

HY-13718

Oglufanide H-Glu-Trp-OH; L-Glutamyl-L-tryptophan	VEGFR HCV Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Oglufanide inhibits vascular endothelial growth factor (VEGF), which may inhibit angiogenesis.

HY-I1060

L-Alloisoleucine (3R)-LS-Isoleucine; L-Allo-isoleucine	Endogenous Metabolite	Others
L-Alloisoleucine is a branched chain amino acid and is a stereo-isomer of L-isoleucine. L-Alloisoleucine is a common constituent of human plasma (albeit at low levels).

HY-B0762

Acetyl-L-carnitine hydrochloride O-Acetyl-L-carnitine (hydrochloride)	Endogenous Metabolite	Neurological Disease
Acetyl-L-carnitine hydrochloride is a blood-brain permeable acetyl ester of the amino acid L-carnitine found in the body. Acetyl-L-carnitine hydrochloride is often used as a dietary supplement, and exibits anti-stress-related psychiatric disorders.

HY-B0166A

L-Ascorbic acid sodium salt (+)-Sodium L-ascorbate; Vitamin C sodium salt; Sodium L-ascorbate	Reactive Oxygen Species Apoptosis	Cancer
L-Ascorbic acid sodium salt is a more bioavailable form of vitamin C that is an antioxidant agent.

HY-11007

GNF-2
Bcr-Abl SARS-CoV Cancer

GNF-2 is a highly selective, allosteric, non-ATP competitive inhibitor of Bcr-Abl. GNF-2 inhibits Ba/F3.p210 proliferation with an IC₅₀ of 138 nM .

HY-B0447A

L-Epinephrine Bitartrate (-)-Epinephrine (+)-bitartrate salt; L-Adrenaline (+)-bitartrate salt	Adrenergic Receptor	Neurological Disease Endocrinology
L-Epinephrine bitartrate is an α-adrenergic and β-adrenergic receptor agonist. L-Epinephrine is a hormone secreted by the medulla of the adrenal glands.

HY-16714

4-Azido-L-phenylalanine p-Azidophenylalanine; p-Azido-L-phenylalanine	Others	Others
4-Azido-L-phenylalanine is an unnatural amino acid, which is used as an effective vibrational reporter of local protein environments.

HY-103701

L-Ascorbic acid 2-phosphate 2-Phospho-L-ascorbic acid	Phosphatase	Metabolic Disease
L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.

HY-W041171

3-Chloro-L-tyrosine	Endogenous Metabolite	Others
3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.

HY-B0396

Tebipenem pivoxil
L084
Bacterial Antibiotic Infection

Tebipenem Pivoxil is a novel oral carbapenem antibiotic.

HY-126154

L48H37	Toll-like Receptor (TLR)	Inflammation/Immunology
L48H37 is an analog of Curcumin (HY-N0005) with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is used for the research of sepsis or lung injury treatment.

HY-17521

Flumorph
SYP-L190
Fungal Infection

Flumorph(SYP-L190) is a carboxylic acid amide (CAA) fungicide.

HY-N0642

α-L-Rhamnose monohydrate	Others	Infection Metabolic Disease Cancer
α-L-Rhamnose monohydrate is a component of the plant cell wall pectic polysaccharides rhamnogalacturonan I and rhamnogalacturonan II. α-L-Rhamnose monohydrate is also a component of bacterial polysaccharides where it plays an important role in pathogenicity.

HY-N0096

Rotundine (-)-Tetrahydropalmatine; L-Tetrahydropalmatine	5-HT Receptor Dopamine Receptor	Neurological Disease
Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC₅₀s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of 5-HT_1A with an IC₅₀ of 370 nM.

HY-102015

6-Biopterin
L-Biopterin
NO Synthase Endogenous Metabolite Cancer Neurological Disease

6-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor.

HY-16126

Carboxyamidotriazole L-651582; CAI	Calcium Channel	Cancer Inflammation/Immunology
Carboxyamidotriazole (L-651582) is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole shows anti-tumor, anti-inflammatory and antiangiogenic effects.

HY-W011978

N-Acetyl-L-tryptophan
Endogenous Metabolite Metabolic Disease

N-Acetyl-L-tryptophan is an endogenous metabolite.
HY-W017006

1-Methyl-L-histidine
Endogenous Metabolite Metabolic Disease

1-Methyl-L-histidine is an objective indicator of meat ingestion and exogenous 3-methylhistidine (3MH) intake.
HY-100177

L-Threonine derivative-1
Others Others

L-Threonine derivative-1 is a acetylsalicylic-L-threonine ester extracted from patent US 20060287244 A1.
HY-113248

3-Nitro-L-tyrosine
Endogenous Metabolite Metabolic Disease

3-Nitro-L-tyrosine is a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions.
HY-W016480

4-Amino-L-phenylalanine
Endogenous Metabolite Metabolic Disease

4-Amino-L-phenylalanine is an endogenous metabolite.

HY-23460

4-Ethynyl-L-phenylalanine	Tryptophan Hydroxylase	Neurological Disease
4-Ethynyl-L-phenylalanine is a selective, reversible, potent and competitive inhibitor of tryptophan hydroxylase (TPH). 4-Ethynyl-L-phenylalanine is a competitive inhibitor with regard to the substrate tryptophan, with a K_i of 32.6 μM. 4-Ethynyl-L-phenylalanine selectively and reversibly inhibits the biosynthesis of serotonin.

HY-B0106

Levetiracetam
UCB L059
mAChR Neurological Disease

Levetiracetam (UCB L059) is a selective M2 muscarinic acetylcholine receptors (mAChR) inhibitor. Antiepileptic agent.

HY-16933

L-Alanosine NSC-153353	Others	Cancer Infection
L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine (NSC-153353) blocks the common de novo purine biosynthesis pathway and, thereby, inhibits tumor cells with MTAP deficiency.

HY-N0623

L-Tryptophan Tryptophan; Tryptophane	Endogenous Metabolite	Metabolic Disease
L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3.

HY-W013573

S-Allyl-L-cysteine	Apoptosis	Cancer Metabolic Disease Inflammation/Immunology Neurological Disease
S-Allyl-L-cysteine, one of the organosulfur compounds found in AGE, possess various biological effects including neurotrophic activity, anti-cancer activity, anti-inflammatory activity.

HY-10957

L-692429 MK-0751	Others	Metabolic Disease
L-692429 (MK-0751) is a benzolactam derivative and a nonpeptidyl growth hormone secretagogue (GHS) agonist. L-692429 binds to G protein-coupled receptor with a K_i of 63 nM.

HY-N5001

Euphorbia Factor L2	Apoptosis	Cancer
Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed (the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. Euphorbia factor L2 shows potent cytotoxicity and induces apoptosis via a mitochondrial pathway.

HY-101404A

L-Homocysteine thiolactone hydrochloride	Others	Cardiovascular Disease
L-Homocysteine thiolactone hydrochloride is an intramolecular thioester of homocysteine; prevents translational incorporation of homocysteine into proteins.

HY-W012382

N-Acetyl-L-tyrosine	Endogenous Metabolite	Metabolic Disease
N-Acetyl-L-tyrosine originates from tyrosine through an AA acetylase, is associated with aromatic L-amino acid decarboxylase deficiency and tyrosinemia I.

HY-W017230

L-Cysteinesulfinic acid monohydrate	mGluR	Neurological Disease
L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.

HY-U00097

L-4-Oxalysine hydrochloride	Fungal	Infection Cancer
L-4-Oxalysine hydrochloride is a natural product isolated from the culture media of Streptomyces roseovirdofuscus in China which has shown antitumor activities.

HY-13715

Norepinephrine Levarterenol; L-Noradrenaline	Endogenous Metabolite Adrenergic Receptor Autophagy	Endocrinology Cardiovascular Disease
Norepinephrine (Levarterenol; L-Noradrenaline) is a β₁-selective adrenergic receptor agonist with EC₅₀ of 5.37 μM.

HY-124009A

L-Cysteic acid monohydrate
Endogenous Metabolite Metabolic Disease

L-Cysteic acid monohydrate is an endogenous metabolite.

HY-15102

MK-0429 L-000845704	Integrin	Inflammation/Immunology Cancer
MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide pan-integrin antagonist with IC₅₀ values of 1.6 nM, 2.8 nM, 0.1 nM, 0.7 nM, 0.5 nM and 12.2 nM for αvβ1, αvβ3, αvβ5, αvβ6, αvβ8 and α5β1, respectively.

HY-113426

Nepsilon-Acetyl-L-lysine
Endogenous Metabolite Others

Nepsilon-Acetyl-L-lysine is a derivative of the amino acid lysine.
HY-131112

N-Pivaloyl-L-tyrosine
Others Others

N-Pivaloyl-L-tyrosine is an N-pivaloyl amino acid ester.
HY-15300

Skepinone-L
CBS3830
p38 MAPK Autophagy Inflammation/Immunology

Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor.

HY-B0729

Polaprezinc Zinc L-carnosine	Others	Inflammation/Immunology
Polaprezinc is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities.

HY-108677

L-368,899 hydrochloride	Oxytocin Receptor	Endocrinology
L-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC₅₀s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively, used as a tocolytic agent.

HY-W017007

3-Methyl-L-histidine	Endogenous Metabolite	Metabolic Disease
3-Methyl-L-histidine is a biomarker for meat consumption, especially chicken. It is also a biomarker for the consumption of soy products.

HY-N0455

L-Arginine (S)-(+)-Arginine	NO Synthase Endogenous Metabolite	Others
L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-59291

N-Acetyl-L-leucine
Endogenous Metabolite Metabolic Disease

N-Acetyl-L-leucine is an endogenous metabolite.

HY-N2557

Euphorbia Factor L1	Apoptosis	Cancer Cardiovascular Disease
Euphorbia Factor L1 is a diterpenoid from Euphorbia lathyris L., reduces the expression of Bcl-2, PI3K, AKT and mTOR protein and mRNA, upregulates cleaved caspase-9 and caspase-3 levels, buts shows no effect on pro-caspase-9 and pro-caspase-3. Euphorbia Factor L1 induces apoptosis, has anticancer, antiadipogenesis, antiosteoclastogenesis and multidrug resistance-modulating effect.

HY-113377A

L-Glyceric acid sodium	Endogenous Metabolite	Metabolic Disease
L-Glyceric acid sodium is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid sodium can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid sodium excretion to distinguish PH1 from PH2.

HY-14596

Genistein NPI 031L	EGFR Autophagy Apoptosis Endogenous Metabolite	Cancer
Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.

HY-102062A

Nω-Propyl-L-arginine hydrochloride N-omega-Propyl-L-arginine hydrochloride	NO Synthase	Neurological Disease
Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a K_i of 57 nM. Nω-Propyl-L-arginine hydrochloride displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS).

HY-107837

2-Phospho-L-ascorbic acid trisodium L-Ascorbic acid 2-phosphate trisodium	c-Met/HGFR Reactive Oxygen Species Endogenous Metabolite
2-Phospho-L-ascorbic acid trisodium acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production.

HY-103701A

L-Ascorbic acid 2-phosphate magnesium 2-Phospho-L-ascorbic acid magnesium	Phosphatase	Metabolic Disease
L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.

HY-113468A

3-O-Methyldopa 3-Methoxy-L-tyrosine; 3-O-Methyl-L-DOPA	Dopamine Receptor Endogenous Metabolite	Neurological Disease
3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine.

HY-14520

Tetrahydrofolic acid L-5,6,7,8-Tetrahydrofolic acid; L-Tetrahydrofolic acid	Endogenous Metabolite	Metabolic Disease
Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid.

HY-128676

N-ε-propargyloxycarbonyl-L-lysine hydrochloride H-L-Lys(Poc)-OH (hydrochloride)	Others	Cancer
N-ε-propargyloxycarbonyl-L-lysine hydrochloride is a modified amino acid (L-lysine) for cancer therapy development.

HY-135128

Dot1L-IN-5
Histone Methyltransferase Cancer

Dot1L-IN-5 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC_{50 SPA DOT1L} of 0.17 nM.

HY-133685

N-Hexanoyl-L-homoserine lactone	Others
N- N-hexanoyl-L-Homoserine lactone regulates virulence in general and in cystic fibrosis, prevents infection, reduces slime and biofilm in commercial agriculture and aquaculture industries, prevents food spoilage, and septicemia in fish.

HY-135127

Dot1L-IN-4
Histone Methyltransferase Cancer

Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC_{50 SPA DOT1L} of 0.11 nM.
HY-17490

Oxaceprol
N-Acetyl-L-hydroxyproline
Others Inflammation/Immunology

Oxaceprol is an anti-inflammatory drug used in the treatment of osteoarthritis.

HY-100783A

(-)-Bicuculline methochloride l-Bicuculline methochloride	GABA Receptor	Neurological Disease
(-)-Bicuculline methochloride (l-Bicuculline methochloride) is a potent GABA_A receptor antagonist. (-)-Bicuculline methochloride blocks afterhyperpolarizations (AHPs) mediated by Ca²⁺-activated K⁺ channels in various types of neurons.

HY-N0667

L-Asparagine (-)-Asparagine; Asn; Asparamide	Endogenous Metabolite	Neurological Disease
L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-117541

Glycyl-glutamine Glycyl-L-glutamine	Others	Neurological Disease
Glycyl-glutamine (Glycyl-L-glutamine), as a enzymatic cleavage product of β-endorphin, is apparently an endogenous antagonist of beta-endorphin(1-31) in several systems. Glycyl-glutamine (Glycyl-L-glutamine) is an activate and stable glutamine-containing neuropeptide over glutamine (Gln).

HY-12597

Quisqualic acid L-Quisqualic acid	iGluR mGluR	Neurological Disease
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC₅₀ of 45 nM and a K_i of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis chinensis.

HY-15321

Etoricoxib MK-0663; L-791456	COX	Inflammation/Immunology Cancer
Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC₅₀s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-17369B

Tirofiban L700462; MK383	Integrin	Cardiovascular Disease
Tirofiban(L700462;MK383) is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist Target: integrin IIb/IIIa Tirofiban hydrochloride monohydrate blocks platelet aggregation and thrombus formation.

HY-B0109

Dorzolamide
L671152; MK507
Carbonic Anhydrase Others

Dorzolamide(L671152; MK507) is an anti-glaucoma agent, which is a carbonic anhydrase inhibitor.
HY-135129

Dot1L-IN-6
Histone Methyltransferase Cancer

Dot1L-IN-6 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC_{50 SPA DOT1L} of 0.19 nM.

HY-N0471A

L-Hyoscyamine sulfate Daturine sulfate	mAChR	Neurological Disease
L-Hyoscyamine sulfate (Daturine sulfate) is a tropane alkaloid that is a secondary metabolite found in certain plants of the solanaceae family. In vitro it has been shown to be an antagonist of mAChR.

HY-101520

Dot1L-IN-1
Histone Methyltransferase Cancer

Dot1L-IN-1 is a highly potent, selective and structurally novel Dot1L inhibitor with a K_i of 2 pM.
HY-W008646

7,8-Dihydro-L-biopterin
Endogenous Metabolite Others

7,8-Dihydro-L-biopterin is an oxidation product of tetrahydrobiopterin.

HY-17578

Pneumocandin B0 L-688786	Fungal Antibiotic	Infection
Pneumocandin B0(L-688786), a key intermediate in the synthesis of the antifungal agent, Cancidas, has led to the identification of several materials with potential for improved performance.

HY-124237A

N-Octanoyl-L-homoserine lactone	Bacterial
N-octanoyl-L-Homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism. N-octanoyl-L-Homoserine lactone can be used for the infection prevention and regulation of virulence in general and in cystic fibro.

HY-P1175

L-R4W2
TRP Channel Neurological Disease

L-R4W2 is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 may act as a potent analgesic.

HY-136409

N-Decanoyl-L-homoserine lactone	Bacterial
N-Decanoyl-L-homoserine lactone is a member of N-acyl-homoserine lactone family. N-Acylhomoserine lactones (AHL) regulate gene expression in Gram-negative bacteria, such as Echerichia and Salmonella, and are involved in quorum sensing, cell to cell communication among bacteria.

HY-W014130A

N-Acetyl-L-arginine dihydrate
Endogenous Metabolite Metabolic Disease

N-Acetyl-L-arginine (dihydrate) is an endogenous metabolite.

HY-W016628

L-Gulono-1,4-lactone	Endogenous Metabolite	Metabolic Disease
L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.

HY-N1420A

Rhamnose monohydrate L-Rhamnose monohydrate	Others	Cancer
Rhamnose monohydrate (L-Rhamnose monohydrate) is a monosaccharide found in plants and bacteria. Rhamnose monohydrate-conjugated immunogens is used in immunotherapies. Rhamnose monohydrate crosses the epithelia via the transcellular pathway and acts as a marker of intestinal absorption.

HY-136595

3,5-Difluoro-L-tyrosine	Phosphatase	Others
3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine can be used to analyze the substrate specificity of protein tyrosine phosphatases (PTPs).

HY-121513

Torcitabine
2'-Deoxy-L-cytidine
HBV Infection

Torcitabine (2'-Deoxy-L-cytidine) is an antiviral agent. Torcitabine has the potential for chronic hepatitis B virus infection treatment.

HY-111827

S-1-Propenyl-L-cysteine	Others	Inflammation/Immunology Cardiovascular Disease
S-1-Propenyl-L-cysteine is a stereoisomer of S-allyl-l-cysteine, extracted from garlic, with immunomodulatory effects and reduces blood pressure in a hypertensive animal model.

HY-B1038

L-Cysteine methyl ester hydrochloride	Others	Inflammation/Immunology
L-Cysteine methyl ester hydrochloride is an antitussive, and an expectorant agent, used to relieve breathing difficulties caused by mucus.

HY-N0650

L-Serine (-)-Serine; (S)-Serine	Endogenous Metabolite	Cancer
L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-100783

(-)-Bicuculline methobromide l-Bicuculline methobromide	GABA Receptor	Neurological Disease
(-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABA_A receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca²⁺-activated K⁺ channels in various types of neurons.

HY-B0488

Clorsulon
L631529; MK401
Parasite Infection

Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.

HY-D0205A

Carbocisteine S-(Carboxymethyl)-L-cysteine	Others	Infection Inflammation/Immunology
Carbocisteine, a mucolytic agent, can be used for the research of chronic obstructive pulmonary disease (COPD).

HY-W014180

N-Acetyl-L-histidine monohydrate	Endogenous Metabolite	Metabolic Disease
N-Acetyl-L-histidine monohydrate, a histidine derivative, is a prominent biomolecule in brain, retina and lens of poikilothermic vertebrates. N-Acetyl-L-histidine monohydrate has a role as an animal metabolite.

HY-W050044

L-Azetidine-2-carboxylic acid
Endogenous Metabolite Metabolic Disease

L-Azetidine-2-carboxylic acid is an endogenous metabolite.

HY-18341

L-Thyroxine Levothyroxine; T4	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology
L-Thyroxine (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

HY-115393A

N-Heptanoyl-L-homoserine lactone	Others
N-Heptanoyl-L-homoserine lactone is a member of N-acyl-homoserine lactone family. N-acyl-homoserine lactones (AHL) regulate gene expression in gram-negative bacteria, such as Echerichia and Salmonella, and are involved in quorum sensing, cell to cell communication among bacteria.

HY-N0225

(-)-Epigallocatechin Epigallocatechin; EGC; L-Epigallocatechin	MMP Autophagy	Cancer
(-)-Epigallocatechin (EGC) is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils.

HY-W015240

N-Acetyl-L-glutamic acid	Endogenous Metabolite	Metabolic Disease
N-Acetyl-L-glutamic acid, a N-acyl-L-amino acid, is a component of animal cell culturing media. N-Acetyl-L-glutamic acid is a metabolite of Saccharomyces cerevisiae and human.

HY-N0406

2"-O-beta-L-galactopyranosylorientin	Others	Metabolic Disease
2"-O-beta-L-galactopyranosylorientin is extracted from the flowers of Trollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate of multidrug resistance protein 2 (MRP2).

HY-B1035

Levobunolol hydrochloride
l-Bunolol hydrochloride
Others Others

Levobunolol hydrochloride is a non-selective beta blocker. It is used topically to manage glaucoma.

HY-B0689

Indinavir MK-639; L-735524	HIV HIV Protease	Inflammation/Immunology
Indinavir(MK-639; L735524) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability.

HY-113524

N-Acetyl-L-aspartic acid
Endogenous Metabolite Others

N-Acetyl-L-aspartic acid is a derivative of aspartic acid.

HY-133684

N-Tetradecanoyl-L-homoserine lactone	Bacterial
N-Tetradecanoyl-L-homoserine lactone is a major chemical modulators of within and between cell communication and regulation. N-Tetradecanoyl-L-homoserine lactone can be used for the study of quorum sensing in vitro.

HY-B0769

Phenylephrine (R)-(-)-Phenylephrine; L-Phenylephrine	Adrenergic Receptor	Cardiovascular Disease Endocrinology
(R)-(-)-Phenylephrine is a selective α₁-adrenoceptor agonist primarily used as a decongestant.

HY-101409A

O-Acetyl-L-serine hydrochloride
Endogenous Metabolite Metabolic Disease

O-Acetyl-L-serine hydrochloride is an endogenous metabolite.

HY-111390

Dot1L-IN-2	Histone Methyltransferase	Cancer
Dot1L-IN-2 is a potent, selective and orally bioavailable inhibitor of Dot1L (a histone methyltransferase), with an IC₅₀ and K_i of 0.4 nM and 0.08 nM, respectively.

HY-15586

L67
DNA Ligase Inhibitor
DNA/RNA Synthesis Cancer

L67 is a novel, competitive human DNA ligase inhibitor, inhibits DNA ligases I and III with IC50 of 10 μM and 10 μM.
HY-126663

N-Me-L-Ala-maytansinol
ADC Cytotoxin Cancer

N-Me-L-Ala-maytansinol is a hydrophobic, cell permeable payload used for making antibody-drug conjugate (ADC).

HY-108357

6-Diazo-5-oxo-L-nor-Leucine L-6-Diazo-5-oxonorleucine; DON	Glutaminase Bacterial Influenza Virus Antibiotic	Cancer Infection Neurological Disease
L-6-Diazo-5-oxonorleucine (L-6-Diazo-5-oxonorleucine) is a glutaminases antagonist with a K_i of 6 μM. L-6-Diazo-5-oxonorleucine exhibits analgesic, antibacterial, antiviral and anticancer properties. L-6-Diazo-5-oxonorleucine displays genetic toxicity in vitro. L-6-Diazo-5-oxonorleucine decreases the self-renewal potential and metastatic ability of tumor cell.

HY-B0987

Ascorbyl palmitate L-Ascorbic acid 6-hexadecanoate; 6-O-Palmitoyl-L-ascorbic acid	Reactive Oxygen Species Endogenous Metabolite	Cancer
Ascorbyl palmitate is an ester formed from ascorbic acid and palmitic acid creating a fat-soluble form of vitamin C, it is also used as an antioxidant food additive.

HY-13573

Biapenem
CLI 86815; L 627; LJC 10627
Bacterial Antibiotic Infection

Biapenem (CLI 86815; L 627; LJC 10627) a parenteral carbapenem antibacterial agent with a broad spectrum.

HY-16714A

4-Azido-L-phenylalanine hydrochloride p-Azidophenylalanine hydrochloride; p-Azido-L-phenylalanine hydrochloride	Others	Others
4-Azido-L-phenylalanine hydrochloride is an unnatural amino acid, which is used as an effective vibrational reporter of local protein environments.

HY-114816

N-Butanoyl-L-homoserine lactone C4-HSL; N-Butyryl-L-homoserine lactone	ADC Linker Bacterial	Infection
N-Butanoyl-L-homoserine lactone is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm.

HY-32291

Methyl L-pyroglutamate (S)-Methyl 5-oxopyrrolidine-2-carboxylate; L-Pyroglutamic acid methyl ester	Others	Others
Methyl L-pyroglutamate ((S)-Methyl 5-oxopyrrolidine-2-carboxylate;L-Pyroglutamic acid methyl ester) is isolated from P. oleracea and has anti-inflammatory activity.

HY-129172A

PD-1/PD-L1-IN 5	PD-1/PD-L1	Cancer Infection Inflammation/Immunology
PD-1/PD-L1-IN 5 is a PD-1/PD-L1 protein/protein interaction inhibitor extracted from patent WO2017222976A1, compound Example 1, has an IC₅₀ of ≤100 nM.

HY-D0844

Glutathione oxidized L-Glutathione oxidized; GSSG	Endogenous Metabolite Reactive Oxygen Species	Metabolic Disease
Glutathione oxidized is produced by the oxidation of glutathione which is a major intracellular antioxidant and detoxifying agent.

HY-140848

Azide-PEG3-L-alanine-Fmoc
PROTAC Linker Cancer

Azide-PEG3-L-alanine-Fmoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-13458

Droxidopa L-DOPS; DOPS; SM5688	Others	Neurological Disease
Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood–brain barrier.

HY-B1480

Ethoxzolamide
Redupresin; L-643786; PNU-4191
Carbonic Anhydrase Bacterial Infection Inflammation/Immunology

Ethoxzolamide is a carbonic anhydrase inhibitor with K_i of 1 nM.

HY-N0666B

Aspartic acid calcium Calcium L-aspartate	Others	Cardiovascular Disease
Aspartic acid calcium (Calcium L-aspartate) is a chelate where calcium is attached to an amino acid naming L-Aspartic acid. L-Aspartic acid is an amino acid and serves as a building block for proteins in the body.

HY-B2246

L-Carnitine hydrochloride (R)-Carnitine hydrochloride	Endogenous Metabolite	Metabolic Disease
L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism.

HY-129405

N-(Ketocaproyl)-D,L-homoserine lactone	Bacterial	Infection
N-(Ketocaproyl)-D,L-homoserine lactone is a natural, very active ligand of LuxR. N-(Ketocaproyl)-D,L-homoserine lactone is a quorum sensing (QS) autoinducer.

HY-106301

Devazepide L-364,718; MK-329	Cholecystokinin Receptor	Metabolic Disease
Devazepide (L-364,718) is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC₅₀s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders.

HY-P1175A

L-R4W2 TFA
TRP Channel Neurological Disease

L-R4W2 TFA is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 TFA may act as a potent analgesic.
HY-101409

O-Acetylserine
O-Acetyl-L-serine
Endogenous Metabolite Others

O-Acetylserine (O-Acetyl-L-serine) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants.

HY-101840

EIPA L593754; MH 12-43	TRP Channel Sodium Channel	Cancer Inflammation/Immunology
EIPA (L593754) is a TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA also inhibits Na⁺/H⁺-exchanger (NHE) and macropinocytosis.

HY-W012499

N-Acetyl-L-methionine N-Acetylmethionine	Endogenous Metabolite	Metabolic Disease
N-Acetyl-L-methionine, a human metabolite, is nutritionally and metabolically equivalent to L-methionine. L-methionine is an indispensable amino acid required for normal growth and development.

HY-13625

Ertapenem sodium L-749345; MK-826	Bacterial Antibiotic	Infection Cancer
Ertapenem sodium is a new long-acting 1-β-methyl carbapenem antibiotic with a broad antibacterial spectrum including common aerobic and anaerobic bacteria and organisms with extended-spectrum β-lactamases.

HY-N6858

4-Hydroxyisoleucine 4-Hydroxy-L-isoleucine	Others	Metabolic Disease
4-Hydroxyisoleucine (4-Hydroxy-L-isoleucine) is an amino acid which can be extracted and purified from fenugreek seeds. 4-Hydroxyisoleucine (4-Hydroxy-L-isoleucine) displays an insulinotropic activity of great interest.

HY-N4112

L-Fucitol
1-Deoxy-D-galactitol
Others Endocrinology

L-Fucitol (1-Deoxy-D-galactitol) is a sugar alcohol isolated from Nutmeg.

HY-13642

RG108 N-Phthalyl-L-tryptophan	DNA Methyltransferase	Cancer
RG108 (N-Phthalyl-L-tryptophan) is a non-nucleoside DNA methyltransferases (DNMTs) inhibitor (IC₅₀=115 nM) that blocks the DNMTs active site. RG108 (N-Phthalyl-L-tryptophan) causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences.

HY-128704A6

c-Kit-IN-3 L-tartrate	c-Kit	Cancer
c-Kit-IN-3 L-tartrate (Compound 18) is a potent and selective c-KIT kinase inhibitor with an IC₅₀s of 4 nM, 8 nM for c-KIT wt and c-KIT T670I, respectively. c-Kit-IN-3 L-tartrate displays great potencies against most of the gain-offunction mutations in the juxtamembrane domain, drugresistant mutations in the ATP binding pocket, and activation loops.

HY-N0455A

L-Arginine hydrochloride (S)-(+)-Arginine hydrochloride	NO Synthase Endogenous Metabolite	Others
L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-75957

DMP 777
L-694458
Elastase Inflammation/Immunology

DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.

HY-14608

(S)-Glutamic acid (+)-L-Glutamic acid	Endogenous Metabolite iGluR Ferroptosis Apoptosis	Neurological Disease
(S)-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-W008315

L-Allothreonine
H-allo-Thr-OH
Endogenous Metabolite Metabolic Disease

L-Allothreonine (H-allo-Thr-OH) is an endogenous metabolite.

HY-121765

Dacisteine N,S-Diacetyl-L-cysteine	Endogenous Metabolite	Metabolic Disease
Dacisteine (N,S-Diacetyl-L-cysteine) is a cysteine derivative and displays a less New Delhi metallo-beta-lactamase-1 (NDM-1) inhibitor with an IC₅₀ value of 1000 μM. Dacisteine can be used for the treatment of cardiovascular and cerebrovascular diseases caused by platelet aggregation.

HY-N0304

L-DOPA Levodopa; 3,4-Dihydroxyphenylalanine	Dopamine Receptor Endogenous Metabolite	Neurological Disease
L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease.

HY-15274

L-798106 CM9; GW671021	Prostaglandin Receptor	Cancer
L-798106 is potent and highly selective prostanoid EP3 receptor antagonist (K_i=0.3 nM), it also has micromolar activities at the EP4, EP1 and EP2 receptors with K_i values of 916 nM, >5000 nM and >5000 nM at EP4, EP1 and EP2, respectively.

HY-15825

IWP L6
Porcn Inhibitor III
Porcupine Cancer

IWP L6 (Porcn Inhibitor III) is a Porcn inhibitor with an EC₅₀ of 0.5 nM.

HY-131039

MDNI-caged-L-glutamate MDNI-glu	Others
MDNI-caged-L-glutamate (MDNI-glu) rapidly and efficiently releases glutamate when photolysed (350-365 nm excitation). MDNI-caged-L-glutamate is inactive at neuronal glutamate receptors (up to 200 μM) and stable at neutral pH. MDNI-caged-L-glutamate is activated by laser to evoke a rapid increase in intracellular ca²⁺ concentration in astrocytes.

HY-B0225

L-(-)-α-Methyldopa MK-351; Methyldopa	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Methyldopa is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.

HY-19191

L-159282 MK 996	Angiotensin Receptor	Cardiovascular Disease Endocrinology
L-159282 is a highly potent, orally active, nonpeptide angiotensin II receptor antagonist, with anti-hypertensive activity.

HY-14407A

Fosaprepitant dimeglumine MK-0517; L785298	Neurokinin Receptor	Neurological Disease Endocrinology Cancer
Fosaprepitant dimeglumine(MK-0517) is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting.

HY-N2042

Cimigenol-3-O-α-L-arabinoside
Others Neurological Disease

Cimigenol-3-O-α-L-arabinoside is a triterpenoid isolated from Cimicifuga foetida L.

HY-P1170

N-terminally acetylated Leu-enkephalin Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH	Opioid Receptor	Neurological Disease
N-terminally acetylated Leu-enkephalin is the N-terminally acetylated form of Leu-enkephalin. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

HY-103048A

PD-1/PD-L1-IN 3 TFA	PD-1/PD-L1	Cancer
PD-1/PD-L1-IN 3 TFA is a PD-1/PD-L1 interaction inhibitor extracted from patent WO2014151634A1, compound 1. PD-1/PD-L1-IN 3 TFA inhibits the binding of human PD-1 to PD-Ll with an IC₅₀ of 9 nM.

HY-129172

PD-1/PD-L1-IN 5 TFA	PD-1/PD-L1	Cancer Infection Inflammation/Immunology
PD-1/PD-L1-IN 5 TFA is a PD-1/PD-L1 protein/protein interaction inhibitor extracted from patent WO2017222976A1, compound Example 1, has an IC₅₀ of ≤100 nM.

HY-20336

Mc-Val-Cit-PABC-PNP Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate	ADC Linker	Cancer
Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W050031

(S)-3-Hydroxybutanoic acid (S)-β-Hydroxybutanoic acid; L-(+)-3-Hydroxybutyric acid; L-β-Hydroxybutyric acid	Endogenous Metabolite	Others
(S)-3-Hydroxybutanoic acid is a normal human metabolite, that has been found elevated in geriatric patients remitting from depression. In humans, 3-Hydroxybutyric acid is synthesized in the liver from acetyl-CoA, and can be used as an energy source by the brain when blood glucose is low.

HY-41919

Mal-L-PA-NH-Boc
mDPR(boc)
ADC Linker Cancer

Mal-L-PA-NH-Boc is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-100468

REV7/REV3L-IN-1	Others	Cancer
REV7/REV3L-IN-1 is a REV7/REV3L interaction inhibitor with an IC₅₀ of 78 μM, which directly binds to REV7 in nuclear magnetic resonance analyses, and inhibits the reactivation of a reporter plasmid containing an interstrand crosslink (ICL) in between the promoter and reporter regions.

HY-N2310

Domoic acid (-)-Domoic acid; L-Domoic acid	iGluR	Neurological Disease
Domoic acid ((-)-Domoic acid; L-Domoic acid) is an excitatory neurotransmitter isolated from a form of marine vegetation, Nitzschia pungens. Domoic acid produces neurotoxic effect through activating kainate receptor.

HY-W010104

L-Methionine sulfoxide H-Met(O)-OH	Endogenous Metabolite	Metabolic Disease
L-Methionine sulfoxide (H-Met(O)-OH), a metabolite of Methionine, induces M1/classical macrophage polarization, and modulates oxidative stress and purinergic signaling parameters.

HY-B0017

Telbivudine Epavudine; L-Thymidine; NV 02B	HBV	Infection
Telbivudine, a specific inhibitor of hepatitis B virus (HBV) replication, is an antiviral drug used in the treatment of hepatitis B infection.

HY-133021

Arazine N-Acetyl-S-farnesyl-L-cysteine	Others	Inflammation/Immunology
Arazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator of G protein and G-protein coupled receptor signaling. Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site.

HY-18732A

L-NMMA acetate Tilarginine acetate; Methylarginine acetate	NO Synthase	Cardiovascular Disease
L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The K_i values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.

HY-10052

Aprepitant MK-0869; MK-869; L-754030	Neurokinin Receptor Bacterial HIV Antibiotic	Neurological Disease Endocrinology Cancer
Aprepitant (MK-0869) is a selective and high-affinity neurokinin 1 receptor antagonist with a K_d of 86 pM.

HY-13715C

Noradrenaline tartrate Levarterenol tartrate; L-Noradrenaline tartrate	Endogenous Metabolite Adrenergic Receptor Autophagy	Endocrinology Cardiovascular Disease
Norepinephrine tartrate (Levarterenol tartrate) is a β₁-selective adrenergic receptor agonist with EC₅₀ of 5.37 μM.

HY-16125

Carboxyamidotriazole Orotate L-651582 Orotate; CAI Orotate	Calcium Channel	Cancer Inflammation/Immunology
Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate shows anti-tumor, anti-inflammatory and antiangiogenic effects.

HY-13715A

Norepinephrine hydrochloride Levarterenol hydrochloride; L-Noradrenaline hydrochloride	Adrenergic Receptor Autophagy	Cardiovascular Disease Endocrinology
Norepinephrine hydrochloride (Levarterenol hydrochloride) is a β₁-selective adrenergic receptor agonist with EC₅₀ of 5.37 μM.

HY-14608A

L-Glutamic acid monosodium salt Monosodium glutamate	iGluR Apoptosis Ferroptosis	Neurological Disease
L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-114245

Se-Methylselenocysteine Methylselenocysteine; Se-Methylseleno-L-cysteine	Apoptosis	Cancer
Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis.

HY-111642

3'-Azido-3'-deoxy-beta-L-uridine
Nucleoside Antimetabolite/Analog Others

3'-Azido-3'-deoxy-beta-L-uridine (Compound 25) is a nucleoside derivative.

HY-N7132

Menthyl acetate L-Menthyl acetate; (-)-Menthyl acetate	Others	Others
Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation.

HY-B1352

L-Ornithine (S)-2,5-Diaminopentanoic acid	Endogenous Metabolite	Others
L-ornithine has an antifatigue effect in increasing the efficiency of energy consumption and promoting the excretion of ammonia.

HY-136614

H-Val-βNA
L-Valine β-naphthylamide
Others Others

H-Val-βNA (L-Valine β-naphthylamide) can be used as an aminopeptidase and a Valine arylamidase substrate.

HY-B0711

Carglumic Acid N-Carbamyl-L-glutamic acid	Others	Cancer
Carglumic acid (N-Carbamyl-L-glutamic acid), a functional analogue of N-acetylglutamate (NAG) and a carbamoyl phosphate synthetase 1 (CPS1) activator, is used to treat acute and chronic hyperammonemia associated with NAG synthase (NAGS) deficiency.

HY-10005

Flavopiridol Alvocidib; L86-8275; HMR-1275	CDK Autophagy HIV	Cancer
Flavopiridol (Alvocidib) is a broad spectrum and competitive inhibitor of CDKs, inhibiting CDK1, CDK2, CDK4 with IC₅₀s of 30, 170, 100 nM, respectively.

HY-Y0479

L-Lactic acid (S)-2-Hydroxypropanoic acid	Bacterial Endogenous Metabolite Antibiotic	Infection
L-Lactic acid is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid.

HY-113468AS

3-O-Methyldopa D3 3-Methoxy-L-tyrosine D3; 3-O-Methyl-L-DOPA D3	Dopamine Receptor Endogenous Metabolite	Neurological Disease
3-O-Methyldopa D3 (3-Methoxy-L-tyrosine D3) is deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine.

HY-B0979

Lobeline hydrochloride α-Lobeline hydrochloride; L-Lobeline hydrochloride	nAChR	Neurological Disease
Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes.

HY-P0133

(Arg)9 Nona-L-arginine; Peptide R9	Others	Neurological Disease
(Arg)9 (Nona-L-arginine;Peptide R9) is a cell-penetrating peptide; exhibits neuroprotective activity with an IC₅₀ of 0.78 μM in the glutamic acid model.

HY-Y0017

L-Norleucine (S)-Norleucine; (S)-2-Aminohexanoic acid	Influenza Virus Endogenous Metabolite	Infection Cancer
L-Norleucine is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

HY-B0689A

Indinavir sulfate MK-639 sulfate; L735524 sulfate	HIV HIV Protease	Infection
Indinavir sulfate(MK-639 sulfate; L735524 sulfate ) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability.

HY-128420

Lobeline sulfate α-Lobeline sulfate; L-Lobeline sulfate	Endogenous Metabolite	Neurological Disease
Lobeline sulfate (α-Lobeline sulfate; L-Lobeline sulfate) is a nonstimulant medication that can alter dopamine uptake in brain. Lobeline sulfate (α-Lobeline sulfate; L-Lobeline sulfate) inhibits nicotine-induced hyperactivity and is effective in smoking cessation.

HY-19989A

MK-571 sodium salt L-660711 sodium salt	Leukotriene Receptor	Inflammation/Immunology
MK-571 sodium salt is a selective, orally active leukotriene D4 receptor antagonist, with K_is of 0.22 and 2.1 nM in guinea pig and human lung membranes.

HY-N6674

Diazepinomicin ECO-4601; TLN-4601; BU 4664L	Ras Apoptosis	Cancer
Diazepinomicin (TLN-4601) is a secondary metabolite produced by Micromonospora sp. Diazepinomicin (TLN-4601) inhibits the EGF-induced Ras-ERK MAPK signaling pathway and induces apoptosis. An anti-tumor agent for K-Ras mutant models.

HY-101410

SDMA Symmetric dimethylarginine; NG,NG'-Dimethyl-L-arginine	Endogenous Metabolite	Inflammation/Immunology
SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity.

HY-W050026

Phenylacetylglutamine
NSC 203800; Phenylacetyl-L-glutamine
Endogenous Metabolite Others

Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation.

HY-118697

N-dodecanoyl-L-Homoserine lactone C12-HSL	Others	Infection
N-dodecanoyl-L-Homoserine lactone (C12-HSL) is a quorum sensing (QS) signaling molecule. N-dodecanoyl-L-Homoserine lactone (C12-HSL) aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa.

HY-113039

L-2-Hydroxyglutaric acid (S)-2-Hydroxyglutaric acid	Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite	Cancer
L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with K_m and K_i of 2.52 mM and 11.13 mM, respectively.

HY-17006

Caspofungin Acetate MK-0991 Acetate; L-743872 Acetate	Fungal Antibiotic	Infection
Caspofungin Acetate (MK-0991 Acetate) is an antifungal drug, and noncompetitively inhibits 1,3-β-d glucan synthase activity.

HY-B0109A

Dorzolamide hydrochloride L671152 hydrochloride; MK507 hydrochloride	Carbonic Anhydrase	Others
Dorzolamide hydrochloride (L671152 Hcl; MK507 Hcl) is an anti-glaucoma agent, which is a carbonic anhydrase inhibitor.

HY-19057A

Vatinoxan hydrochloride MK-467 hydrochloride; L-659066 hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology
Vatinoxan hydrochloride (MK-467 hydrochloride;L-659066 hydrochloride) is a peripheral α2 adrenergic receptor antagonist.

HY-B0215

Acetylcysteine N-Acetylcysteine; N-Acetyl-L-cysteine; NAC	Reactive Oxygen Species Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus	Infection Neurological Disease
Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities.

HY-131183

PROTAC PD-1/PD-L1 degrader-1	PROTAC PD-1/PD-L1	Inflammation/Immunology
PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 degrader, inhibits PD-1/PD-L1 interaction with an IC₅₀ of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner.

HY-18341A

L-Thyroxine sodium salt pentahydrate Sodium levothyroxine pentahydrate	Thyroid Hormone Receptor	Endocrinology
L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

HY-18729A

L-NAME hydrochloride NG-Nitroarginine methyl ester hydrochloride	NO Synthase	Cancer
L-NAME hydrochloride inhibits NOS with an IC₅₀ of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC₅₀ value of 1.4 μM.

HY-116016

Etilevodopa L-DOPA ethyl ester; Levodopa ethyl ester	Dopamine Receptor Drug Metabolite	Neurological Disease
Etilevodopa (L-Dopa ethyl ester), an ethyl-ester prodrug of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable prodrug as it facilitates CNS penetration and delivers dopamine.

HY-140846

N-Fmoc-N'-(azido-PEG4)-L-Lysine
PROTAC Linker Cancer

N-Fmoc-N'-(azido-PEG4)-L-Lysine is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-112716

N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride	Others	Cancer
N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death.

HY-P0197

Neurokinin A
α-Neurokinin; Neuromedin L; Substance K
Neurokinin Receptor Neurological Disease Endocrinology

Neurokinin A acts via neurokinin 2 (NK-2) receptor.

HY-N6821

2-O-α-D-Glucopyranosyl-L-ascorbic Acid	Others	Cancer
2-O-α-D-Glucopyranosyl-L-ascorbic Acid is a glucoside derivative of ascorbic acid, shows anti-cancer activity after enzymatic hydrolysis to ascorbic acid.

HY-B0471

Phenylephrine hydrochloride (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
(R)-(-)-Phenylephrine hydrochloride is a selective α₁-adrenoceptor agonist with pK_is of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

HY-131347

PD-1/PD-L1-IN-NP19	PD-1/PD-L1	Cancer Inflammation/Immunology
PD-1/PD-L1-IN-NP19 is a PD-1/PD-L1 inhibitor, with an IC₅₀ of 12.5 nM for human PD-1/PD-L1 interaction. PD-1/PD-L1-IN-NP19 could activate the immune microenvironment in tumor, which may contribute to its antitumor effects.

HY-N0457A

L-Chicoric Acid (-)-Chicoric acid; trans-Caffeoyltartaric acid	HIV Integrase HIV	Infection Cancer
L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC₅₀ of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture.

HY-106376

D,L-Buthionine-(S,R)-sulfoximine
Butionine sulfoximine
Ferroptosis Cancer

D,L-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

HY-10572

Efavirenz DMP 266; EFV; L-743726	Reverse Transcriptase HIV Autophagy	Infection Cancer
Efavirenz is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅ of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture.

HY-113025A

L-hydroxylysine dihydrochloride (2S,5R)-5-Hydroxylysine dihydrochloride	Endogenous Metabolite	Others
L-hydroxylysine dihydrochloride ((2S,5R)-5-Hydroxylysine dihydrochloride), an amino acid, is exclusive to collagen protein, which is formed by posttranslational hydroxylation of some lysine residues.

HY-N0215

L-Phenylalanine (S)-2-Amino-3-phenylpropionic acid	Calcium Channel iGluR Endogenous Metabolite	Metabolic Disease
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca⁺ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (K_B of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.

HY-111825

1-PeCSO S-1-Propenyl-L-cysteine sulfoxide	Others	Others
1-PeCSO is isolated from onion or garlic bulbs, acts as a key compound in garlic greening, and reacts with lachrymatory factor synthase.

HY-B0932

Levocarnitine propionate hydrochloride L-Propionylcarnitine chloride; ST-261	Others	Others
Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride; ST-261) is used to treat the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.

HY-133513

(±)-H3RESCA-TFP (±)-H3L28	Others	Cancer
(±)-H3RESCA-TFP ((±)-H3L28) is a tetrafluorophenyl ester derivative of restrained complexing agent (RESCA). (±)-H3RESCA-TFP can be used to conjugate the chelator with a biomolecule via amine coupling (e.g., N terminus and/or the ε-amino groups of lysine).

HY-122872

MKK7-COV-9	p38 MAPK	Cancer
MKK7-COV-9 is a potent and selective covalent inhibitor of MKK7 and targets a specific protein–protein interaction of MKK7. MKK7-COV-9 blocks primary B cell activation in response to LPS with an EC₅₀ of 4.98 μM.

HY-129974

3,3'-Diiodo-L-thyronine 3,3'-T2	Endogenous Metabolite COX	Metabolic Disease
3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity.

HY-B0919

Azaserine CI-337; O-Diazoacetyl-L-serine; P-165	Bacterial Antibiotic	Cancer Infection
Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase, a key enzyme responsible for glutamine metabolism.

HY-B1065

Aceglutamide α-N-Acetyl-L-glutamine; N2-Acetylglutamine	Autophagy Endogenous Metabolite	Neurological Disease
Aceglutamide (α-N-Acetyl-L-glutamine) is a psychostimulant and nootropic, used to improve memory and concentration.

HY-B0225B

L-(-)-α-Methyldopa (hydrate) MK-351 hydrate; Methyldopa hydrate	Adrenergic Receptor	Cardiovascular Disease Endocrinology
L-(-)-α-Methyldopa hydrate is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.

HY-B0225A

L-(-)-α-Methyldopa hydrochloride MK-351 hydrochloride; Methyldopa hydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
L-(-)-α-Methyldopa hydrochloride is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.

HY-136155

Fmoc-NH-Azide-PEG4-L-Lysine-PFP ester	ADC Linker	Cancer
Fmoc-NH-Azide-PEG4-L-Lysine-PFP ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-112885B

nor-NOHA monoacetate Nω-Hydroxy-nor-L-arginine monoacetate	Arginase	Metabolic Disease
nor-NOHA (Nω-Hydroxy-nor-L-arginine) monoacetate is a potent and selective arginase inhibitor. nor-NOHA monoacetate inhibits rat liver arginase with a K_i of 0.5 µM.

HY-112885A

nor-NOHA acetate Nω-Hydroxy-nor-L-arginine acetate	Arginase Apoptosis	Cancer Metabolic Disease Inflammation/Immunology
nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dysfunction, immunosuppression and metabolism.

HY-114557

NSC 90469
3,5-Diiodo-L-thyronine
Endogenous Metabolite Metabolic Disease

NSC 90469 is an endogenous metabolite.

HY-101840A

EIPA hydrochloride L593754 hydrochloride; MH 12-43 hydrochloride	TRP Channel Sodium Channel	Cancer Inflammation/Immunology
EIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA hydrochloride also inhibits Na⁺/H⁺-exchanger (NHE) and macropinocytosis.

HY-B1122

L-Cycloserine (S)-Cycloserine; (S)-4-Amino-3-isoxazolidone	GABA Receptor HIV	Neurological Disease Cancer
L-Cycloserine ((S)-4-Amino-3-isoxazolidone) irreversibly inhibits GABA pyridoxal 5′-phosphate-dependent aminitransferase in E.

HY-N0562

5,15-Diacetyl-3-benzoyllathyrol
Euphorbia factor L3
Others Cancer

5,15-Diacetyl-3-benzoyllathyrol is one of the lathyrane diterpenoids, that has anti-cancer activity.

HY-B0617

S-Adenosyl-L-methionine Ademetionine; S-Adenosyl methionine; AdoMet	Endogenous Metabolite	Cancer Inflammation/Immunology Neurological Disease
S-Adenosyl-L-methionine (Ademetionine) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research.

HY-19717

DCVC
S-[(1E)-1,2-dichloroethenyl]--L-cysteine
TNF Receptor

DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.

HY-A0167

Gadopentetate dimeglumine SH-L-451A; Gadopentetic acid dimeglumine salt	Others	Cancer
Gadopentetate dimeglumine (SH-L-451A) is used in combination with magnetic resonance imaging (MRI) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on the MRI.

HY-W015114

L-2-Hydroxyglutaric acid disodium (S)-2-Hydroxyglutaric acid disodium	Histone Demethylase Mitochondrial Metabolism	Cancer
L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with K_m and K_i of 2.52 mM and 11.13 mM, respectively.

HY-13715B

Norepinephrine bitartrate monohydrate Levarterenol bitartrate monohydrate; L-Noradrenaline bitartrate monohydrate	Adrenergic Receptor Autophagy	Cardiovascular Disease Endocrinology
Norepinephrine bitartrate monohydrate (Levarterenol bitartrate monohydrate; L-Noradrenaline bitartrate monohydrate) is a β₁-selective adrenergic receptor agonist with EC₅₀ of 5.37 μM.

HY-14743

Golotimod SCV 07; Gamma-D-glutamyl-L-tryptophan	Bacterial STAT	Infection Inflammation/Immunology
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2).

HY-13682

Mifamurtide
MTP-PE; L-MTP-PE; CGP 19835
TRP Channel Cancer

Mifamurtide (MTP-PE; CGP19835) is a drug against osteosarcoma.

HY-114348

N,N'-Diacetyl-L-cystine DiNAC; (Ac-Cys-OH)2	Others	Cardiovascular Disease
N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits.

HY-N4310

Taxifolin 7-O-rhamnoside
Taxifolin 7-O-α-L-rhamnoside
Others Infection

Taxifolin 7-O-rhamnoside (Taxifolin 7-O-α-L-rhamnoside) is a flavonoid isolated from Hypericum japonicum.
HY-Y0068

NSC 45699
N-Acetyl-L-phenylalanine; N-Acetylphenylalanine
Endogenous Metabolite Metabolic Disease

NSC 45699 is an endogenous metabolite.

HY-106376B

D,L-Buthionine-(S,R)-sulfoximine hydrochloride Buthionine sulfoximine hydrochloride	Ferroptosis	Cancer
D,L-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

HY-A0070A

Liothyronine Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Thyroid Hormone Receptor Endogenous Metabolite	Cancer Endocrinology
Liothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.

HY-140847

N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester	PROTAC Linker	Cancer
N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-A0124A

Sapropterin dihydrochloride 6R-BH4 dihydrochloride; 6R-Tetrahydro-L-biopterin dihydrochloride	Others	Cardiovascular Disease
Sapropterin dihydrochloride is a synthetic form of BH4 that is approved for the treatment of BH4 responsive PKU.

HY-100228A

SKF89976A hydrochloride d,l-SKF89976A hydrochloride	GABA Receptor	Neurological Disease
SKF89976A hydrochloride is a selective GABA transporter (GAT-1) inhibitor with IC₅₀s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively.

HY-15321S

Etoricoxib D4 MK-0663 D4; L-791456 D4	COX	Others
Etoricoxib D4 (MK-0663 D4) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC₅₀s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-10006

Flavopiridol Hydrochloride Alvocidib Hydrochloride; L86-8275 Hydrochloride; HMR-1275 Hydrochloride	CDK Autophagy HIV	Cancer
Flavopiridol Hydrochloride (Alvocidib Hydrochloride) is a broad inhibitor of CDK, competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 with IC₅₀s of 30, 170, 100 nM, respectively.

HY-13770

Troxacitabine
BCH 4556; L-OddC; SPD 758
Others Cancer

Troxacitabine is nucleoside analog with potent anticancer activity.

HY-17380

(S)-Timolol Maleate L-714,465 Maleate; MK 950	Adrenergic Receptor	Neurological Disease Cardiovascular Disease
(S)-Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. (S)-Timolol Maleate is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. (S)-Timolol Maleate can be used for hypertension, angina pectoris and myocardial infarction.

HY-100260

beta-L-D4A
2'3'-didehydro-2'3'-dideoxyadenosine
HIV Infection

beta-L-D4A is a nucleoside HIV-1 reverse transcriptase inhibitor.

HY-N2174

Ophiogenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside	Others	Cardiovascular Disease
Ophiogenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside, a terpenoid glycoside from Ophiopogon japonicus roots, has good pharmacological effects on the cardiovascular system.

HY-19991

BMS-1
PD-1/PD-L1 inhibitor 1
PD-1/PD-L1 Apoptosis Cancer Inflammation/Immunology

BMS-1 is an inhibitor of the PD-1/PD-L1 protein/protein interaction (IC₅₀ between 6 and 100 nM).

HY-N6958

2-O-β-D-Glucopyranosyl-L-ascorbic acid AA-2βG	Others	Cancer Metabolic Disease
2-O-β-D-Glucopyranosyl-L-ascorbic acid (AA-2βG), isolated from Lycium Fruit, is a stable vitamin C analog with anti-tumor activity.

HY-116016A

Etilevodopa hydrochloride L-DOPA ethyl ester hydrochloride; Levodopa ethyl ester hydrochloride	Dopamine Receptor Drug Metabolite	Neurological Disease
Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester prodrug of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable prodrug as it facilitates CNS penetration and delivers dopamine.

HY-N5128

Apigenin6-C-α-L-arabinopyranosyl-8-C-β-D-xylopyranoside
Others Others

Apigenin6-C-α-L-arabinopyranosyl-8-C-β-D-xylopyranoside is a natural flavanone compound.

HY-17552

sn-Glycero-3-phosphocholine Choline Alfoscerate; Alpha-GPC; L-α-GPC	AChE Endogenous Metabolite	Neurological Disease
sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. sn-Glycero-3-phosphocholine (Choline Alfoscerate) has significant effects on cognitive function with a good safety profile and tolerability, and is effective in the treatment of Alzheimer's disease and dementia.

HY-W018035

DL-Glyceric Acid Glyceric Acid (20% in Water,ca.2 mol/L)	Endogenous Metabolite	Metabolic Disease
DL-Glyceric Acid is a compound that is secreted excessively in the urine by patients suffering from D-glyceric aciduria.

HY-P0108

Angiotensin II 5-valine
Valine angiotensin II; 5-L-Valine angiotensin II
Angiotensin Receptor Cancer Endocrinology

Angiotensin II 5-valine is an agonist of angiotensin receptor.

HY-100217

D,L-3-Indolylglycine α-Amino-1H-indole-3-acetic acid	Others	Others
D,L-3-Indolylglycine is an unnatural amino acid that is very similar to Tryptophan, with the indole moiety directly attached to the α-position.

HY-W050026S

Phenylacetylglutamine-D5 NSC 203800-D5; Phenylacetyl-L-glutamine-D5	Others	Others
Phenylacetylglutamine-D5 (NSC 203800-D5;Phenylacetyl-L-glutamine-D5) is a deuterated form of Phenylacetylglutamine. Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation.

HY-131096

L-Proline 4-methoxy-β-naphthylamide hydrochloride H-Pro-4MβNA hydrochloride	Others	Cancer
L-Proline 4-methoxy-β-naphthylamide hydrochloride (H-Pro-4MβNA hydrochloride) can be used for Fap-activated anti-tumor compounds preparaction.

HY-12686

5Z-7-Oxozeaenol FR148083; L783279; LL-Z 1640-2	MAP3K VEGFR	Infection Inflammation/Immunology
5Z-7-Oxozeaenol is a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC₅₀s of 8 nM and 52 nM, respectively.

HY-16477

Talaporfin sodium
ME2906; Mono-L-aspartyl chlorin e6; NPe6
Others Others

Talaporfin (ME2906; NPe6) is a photosensitizer used in photodynamic therapy (PDT).

HY-14743B

Golotimod hydrochloride SCV 07 hydrochloride; Gamma-D-glutamyl-L-tryptophan hydrochloride	Bacterial STAT	Infection Inflammation/Immunology
Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod hydrochloride (SCV 07 hydrochloride) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod hydrochloride (SCV 07 hydrochloride) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2).

HY-14743A

Golotimod TFA SCV 07 TFA; Gamma-D-glutamyl-L-tryptophan TFA	Bacterial STAT	Infection Inflammation/Immunology
Golotimod TFA (SCV 07 TFA), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod TFA (SCV 07 TFA) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod TFA (SCV 07 TFA) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2).

HY-19695

(-)-p-Bromotetramisole oxalate L-p-Bromotetramisole oxalate; 6-Bromolevamisole oxalate; (-)-p-Bromolevamisole oxalate	Phosphatase	Cancer
(-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor.

HY-B0617A

S-Adenosyl-L-methionine tosylate Ademetionine tosylate; S-Adenosyl methionine tosylate; AdoMet tosylate	Endogenous Metabolite	Cancer Inflammation/Immunology Neurological Disease
S-Adenosyl-L-methionine tosylate (Ademetionine tosylate) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research.

HY-101053

Src Inhibitor 1 Src Kinase Inhibitor 1; Src-l1	Src	Cancer
Src Inhibitor 1 is a potent and selective dual site Src tyrosine kinase inhibitor with IC₅₀ values of 44 nM for Src and 88nM for Lck.

HY-A0070

Liothyronine sodium Triiodothyronine sodium; 3,3',5-Triiodo-L-thyronine sodium; T3 sodium	Thyroid Hormone Receptor	Cancer Endocrinology
Liothyronine sodium is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.

HY-130946

NH2-C5-PEG4-N3-L-Lysine-PEG3-N3
ADC Linker Cancer

NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-108730

Avelumab Anti-Human PD-L1, Human Antibody; MSB 0010718C; MSB0010718C	PD-1/PD-L1	Cancer Inflammation/Immunology
Avelumab is a fully human IgG1 anti-PD-L1 monoclonal antibody with potential antibody-dependent cell-mediated cytotoxicity.

HY-N6964

Quercetin 3-O-β-D-(6''-p-coumaroyl)glucopyranosyl(1→2)-α-L-rhamnopyranoside Quercetin-3-O-[2-O-(6-O-p-hydroxyl-E-coumaroyl)-D-glucosyl]-(1→2)-L-rhamnoside	Others	Metabolic Disease
Quercetin 3-O-β-D-(6''-p-coumaroyl)glucopyranosyl(1→2)-α-L-rhamnopyranoside (Quercetin-3-O-[2-O-(6-O-p-hydroxyl-E-coumaroyl)-D-glucosyl]-(1→2)-L-rhamnoside) is one of the major antioxidants of Ginkgo biloba leaves.

HY-100839

(RS)-(Tetrazol-5-yl)glycine D,L-(tetrazol-5-yl)glycine; LY 285265	iGluR	Neurological Disease
(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a highly potent and selective N-methyl-D-aspartate (NMDA) receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC₅₀s of 99 nM, 1.7 μM for GluN1/GluN2D and GluN1/GluN2A, respectively. (RS)-(Tetrazol-5-yl)glycine induces seizure responses and Fos in mice.

HY-N7404

Nε,Nε,Nε-Trimethyllysine chloride Ne-(Trimethyl)-L-lysine chloride; H-Lys(Me)3-OH chloride	Endogenous Metabolite	Others
Nε,Nε,Nε-Trimethyllysine chloride serves as a precursor for gut flora-dependent formation of N,N,N-trimethyl-5-aminovaleric acid (TMAVA).

HY-120944

BAY-7598	MMP	Inflammation/Immunology
BAY-7598 is a potent, orally bioavailable, and selective MMP12 inhibitor probe with IC₅₀s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively.

HY-W010271

(2S,3R,4S)-4-Hydroxyisoleucine (2S,3R,4S)-4-Hydroxy-L-isoleucine	Others	Metabolic Disease
(2S,3R,4S)-4-Hydroxyisoleucine is an orally active compound isolated from Trigonella foenum-graecum, with anti-diabetes and anti-diabetic nephropathy activity.

Cat. No.	Product Name	Type

HY-101937

L-ANAP
Fluorescent Dyes/Probes

L-ANAP is a genetically encodable and polarity-sensitive fluorescent unnatural amino acid (Uaa).
HY-101937B

L-ANAP hydrochloride
Fluorescent Dyes/Probes

L-ANAP hydrochloride is a genetically encodable and polarity-sensitive fluorescent unnatural amino acid (Uaa).

HY-D0853

H-L-Photo-lysine	Fluorescent Dyes/Probes
H-L-Photo-lysine is a diazirine-containing lysine amino acid and is a photo-cross-linker. H-L-Photo-lysine can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. H-L-Photo-lysine acts as a UV light-activated photo-crosslinking probe.

HY-D0720

Lucigenin NSC-151912; L-6868	Fluorescent Dyes/Probes
Lucigenin(L-6868; NSC-151912) is a chemiluminescent probe used to indicate the presence of endogenously generated superoxide anion radicals in cells.

HY-D0853A

H-L-Photo-lysine hydrochloride	Fluorescent Dyes/Probes
H-L-Photo-lysine hydrochloride is a diazirine-containing lysine amino acid and is a photo-cross-linker. H-L-Photo-lysine hydrochloride can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. H-L-Photo-lysine hydrochloride acts as a UV light-activated photo-crosslinking probe.

Cat. No.	Product Name	Type

HY-D0187

L-Glutathione reduced GSH; γ-L-Glutamyl-L-cysteinyl-glycine	Biochemical Assay Reagents
L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.

HY-15911

CNP-AFU
2-Chloro-4-nitrophenyl α-L-fucopyranoside
Enzyme Substrates

CNP-AFU (2-Chloro-4-nitrophenyl α-L-fucopyranoside) is a substrate for alpha-L-fucosidase(AFU).

HY-19695

(-)-p-Bromotetramisole oxalate L-p-Bromotetramisole oxalate; 6-Bromolevamisole oxalate; (-)-p-Bromolevamisole oxalate	Biochemical Assay Reagents
(-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor.

Cat. No.	Product Name	Target	Research Area

HY-128434

L-Leucyl-L-alanine
Endogenous Metabolite Metabolic Disease

L-Leucyl-L-alanine is a simple dipeptide composed of L-leucine and L-alanine.

HY-P1923

L-Asparaginase L-ASNase	Peptides	Cancer
L-Asparaginase (L-ASNase), a hydrolase that catalyzes the conversion of L-asparagine, used in acute lymphoblastic leukemia treatment. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis.

HY-P1171

N-terminally acetylated Endomorphin-1
Ac-L-Tyr-L-Pro-L-Trp-L-Phe-CONH2
Peptides Neurological Disease

N-terminally acetylated Endomorphin-1 is a modified Endomorphin-1.
HY-P0069A

L-JNKI-1
JNK Neurological Disease

L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK.
HY-P1175

L-R4W2
TRP Channel Neurological Disease

L-R4W2 is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 may act as a potent analgesic.
HY-P1175A

L-R4W2 TFA
TRP Channel Neurological Disease

L-R4W2 TFA is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 TFA may act as a potent analgesic.

HY-133026

N-Acetylcarnosine N-Acetyl-L-carnosine	Peptides	Inflammation/Immunology
N-Acetylcarnosine, a natural histidine-containing dipeptide, is a source of pharmacological principal L-carnosine. N-Acetylcarnosine is a potent ophthalmic drug in human cataracts.

HY-W013750

Fmoc-Arg-OH
Fmoc-L-Arginine
Peptides Others

Fmoc-Arg-OH (Fmoc-L-Arginine), an Fmoc modified Arginine, is a used in peptide synthesis.

HY-P1170

N-terminally acetylated Leu-enkephalin Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH	Opioid Receptor	Neurological Disease
N-terminally acetylated Leu-enkephalin is the N-terminally acetylated form of Leu-enkephalin. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

HY-103048A

PD-1/PD-L1-IN 3 TFA	PD-1/PD-L1	Cancer
PD-1/PD-L1-IN 3 TFA is a PD-1/PD-L1 interaction inhibitor extracted from patent WO2014151634A1, compound 1. PD-1/PD-L1-IN 3 TFA inhibits the binding of human PD-1 to PD-Ll with an IC₅₀ of 9 nM.

HY-112173

Prolylleucine
((Benzyloxy)carbonyl)-L-prolyl-D-leucine
Peptides Cardiovascular Disease

Prolylleucine is a dipeptide containing branched-chain amino acids.
HY-P0197

Neurokinin A
α-Neurokinin; Neuromedin L; Substance K
Neurokinin Receptor Neurological Disease Endocrinology

Neurokinin A acts via neurokinin 2 (NK-2) receptor.
HY-111922

H-Gly-Gly-Pro-OH
Glycyl-glycyl-L-proline
Peptides Others

H-Gly-Gly-Pro-OH is a peptide with 3 amino acid.

HY-P0133A

(Arg)9 TFA Nona-L-arginine TFA; Peptide R9 TFA	Peptides	Neurological Disease
(Arg)9 TFA (Nona-L-arginine TFA), a cell-penetrating peptide, exhibits neuroprotective activity with an IC₅₀ of 0.78 μM in the glutamic acid model.

HY-P0108

Angiotensin II 5-valine
Valine angiotensin II; 5-L-Valine angiotensin II
Angiotensin Receptor Cancer Endocrinology

Angiotensin II 5-valine is an agonist of angiotensin receptor.

Cat. No.	Product Name	Target	Research Area

HY-108730

Avelumab Anti-Human PD-L1, Human Antibody; MSB 0010718C; MSB0010718C	PD-1/PD-L1	Cancer Inflammation/Immunology
Avelumab is a fully human IgG1 anti-PD-L1 monoclonal antibody with potential antibody-dependent cell-mediated cytotoxicity.

Cat. No.	Product Name	Target	Category

HY-N2596

Isoscabertopin
Others Terpenoids and Glycosides

Isoscabertopin is a sesquiterpene lactone isolated from Elephantopus scaber L and shows anti-tumor activities.

HY-N2905

Aurantiamide acetate Asperglaucide	Cathepsin	Natural Products
Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases.

HY-128434

L-Leucyl-L-alanine
Endogenous Metabolite Acids and Aldehydes

L-Leucyl-L-alanine is a simple dipeptide composed of L-leucine and L-alanine.
HY-W010042

L-Glucose
L-(-)-Glucose
Others Saccharides and Glycosides

L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose can promote food intake.

HY-W014102

L-Alanyl-L-glutamine	Endogenous Metabolite	Acids and Aldehydes
L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations.

HY-78139

L-Xylose
L-(-)-Xylose
Others Saccharides and Glycosides

L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type.

HY-N1436

L-(+)-Abrine L-Abrine; L-N-Methyltryptophan; N-α-Methyl-L-tryptophan	Others	Alkaloids
L-(+)-Abrine, a lethal albumin found in Abrus precatorius seeds, is an acute toxic alkaloid and chemical marker for abrin.

HY-D0187

L-Glutathione reduced GSH; γ-L-Glutamyl-L-cysteinyl-glycine	Endogenous Metabolite Reactive Oxygen Species Ferroptosis	Natural Products
L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.

HY-15129

O-Phospho-L-serine L-Serine O-phosphate; L-SOP	mGluR Endogenous Metabolite	Alkaloids Acids and Aldehydes
O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.

HY-Y0293

L-Tartaric acid
L-(+)-Tartaric acid
Endogenous Metabolite Acids and Aldehydes

L-Tartaric acid (L-(+)-Tartaric acid) is an endogenous metabolite.

HY-N0229

L-Alanine L-2-Aminopropionic acid	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.

HY-N6960

L-Stepholidine Stepholidine; (-)-Stepholidine; L-SPD	Dopamine Receptor	Alkaloids
L-Stepholidine (Stepholidine), an alkaloid extract of the Chinese herb Stephania intermedia, is the first compound known to exhibit mixed dopamine D1 receptor agonist/D2 antagonist properties. L-Stepholidine (Stepholidine) has neuroprotective effect and inhibits heroin-induced reinstatement. L-Stepholidine (Stepholidine) is a potential medication for the treatment of opiate addiction.

HY-113144

L-Hexanoylcarnitine
Endogenous Metabolite Natural Products

L-Hexanoylcarnitine is an acylcarnitine and is found to be associated with celiac disease.

HY-N0391

L-Citrulline	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.

HY-W015611

L-(+)-Arabinose	Endogenous Metabolite	Saccharides and Glycosides
L-(+)-Arabinose selectively inhibits intestinal sucrase activity in a noncompetitive manner and suppresses the plasma glucose increase due to sucrose ingestion.

HY-W009749

L-Cystathionine
Endogenous Metabolite Natural Products

L-Cystathionine is a key nonprotein amino acid related to metabolic conditions.

HY-40135

L-Hydroxyproline	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.

HY-N0473

L-Tyrosine
Endogenous Metabolite Natural Products

L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
HY-B1000A

L-SelenoMethionine
Endogenous Metabolite Apoptosis Alkaloids Acids and Aldehydes

L-SelenoMethionine is a major natural food-form of selenium.
HY-N0771

L-Isoleucine
Endogenous Metabolite Alkaloids Acids and Aldehydes

L-isoleucine is a nonpolar hydrophobic amino acid. L-Isoleucine is an essential amino acid.
HY-113161

L-Octanoylcarnitine
Endogenous Metabolite Natural Products

L-Octanoylcarnitine is the physiologically active form of octanoylcarnitine.

HY-N2375

L-Quebrachitol	Wnt β-catenin	Natural Products
L-Quebrachitol is a natural product isolated from many plants, promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway.

HY-W010347

L-Homocysteine	Endogenous Metabolite	Acids and Aldehydes
L-Homocysteine, a homocysteine metabolite, is a homocysteine that has L configuration. L-Homocysteine induces upregulation of cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia.

HY-N0717

L-Valine
Endogenous Metabolite Alkaloids Acids and Aldehydes

L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid.

HY-W013494

L-Carnosine	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging.

HY-Y0337

L-Cysteine
Endogenous Metabolite Ferroptosis Acids and Aldehydes

L-Cysteine is a thiol-containing non-essential amino acid that is oxidized to form cystine.

HY-104026

L-Kynurenine	Aryl Hydrocarbon Receptor Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.

HY-113147

L-Palmitoylcarnitine
Endogenous Metabolite Acids and Aldehydes

L-Palmitoylcarnitine is a fatty acid metabolite.
HY-N0486

L-Leucine
mTOR Alkaloids Acids and Aldehydes

L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
HY-Y0399

L-Norvaline
Endogenous Metabolite Acids and Aldehydes

L-Norvaline is an endogenous metabolite.

HY-N0394

L-Cystine	Endogenous Metabolite Ferroptosis	Alkaloids Acids and Aldehydes
L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes.

HY-N0832

L-Histidine	Mitochondrial Metabolism Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Histidine is an essential amino acid for infants. L-Histidine is an inhibitor of mitochondrial glutamine transport.

HY-Y0252

L-Proline
Endogenous Metabolite Acids and Aldehydes

L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.

HY-W018004

L-Homocitrulline	Endogenous Metabolite	Antibiotics
L-Homocitrulline is metabolized to homoarginine through homoargininosuccinate via the urea cycle pathway and its metabolic abnormality could lead to Lysinuric Protein Intolerance (LPI).

HY-W002292

L-Homoserine	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Homoserine is a non - protein amino acid, which is an important biosynthetic intermediate of threonine, methionine and lysine.

HY-W040141

L-Arabinitol	Endogenous Metabolite	Natural Products
L-Arabinitol is a potential biomarker for the comsuption of the food products such as sweet potato, deerberry, moth bean, and is also associated with Alzheimer's disease and ribose-5-phosphate isomerase deficiency.

HY-N0658

L-Threonine
Endogenous Metabolite Alkaloids Acids and Aldehydes

L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed.
HY-WAA0142

L-Prolylglycine
Endogenous Metabolite Acids and Aldehydes

L-Prolylglycine is an endogenous metabolite.

HY-W011690

L-Homocystine	Endogenous Metabolite	Acids and Aldehydes
L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.

HY-129476

L-Canaline	Parasite Endogenous Metabolite	Natural Products
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite *Plasmodium falciparum* with an IC₅₀ of 297 nM. L-Canaline has anticancer and antiproliferative effects.

HY-N0326

L-Methionine	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.

HY-N0469

L-Lysine	Endogenous Metabolite Virus Protease	Alkaloids Acids and Aldehydes
L-lysine is an essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions.

HY-W014233

L-Histidinol dihydrochloride
Endogenous Metabolite Natural Products

L-Histidinol dihydrochloride is an endogenous metabolite.

HY-101414

L-DABA L-2,4-Diaminobutyric acid	GABA Receptor Endogenous Metabolite	Acids and Aldehydes
L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC₅₀ of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

HY-B0166

L-Ascorbic acid
L-Ascorbate; Vitamin C
Reactive Oxygen Species Apoptosis Natural Products

L-Ascorbic acid is an effective reducing agent and donor antioxidant.

HY-B1716

L-5-Hydroxytryptophan L-5-HTP; Oxitriptan	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia.

HY-B2188

S-Methyl-L-cysteine L-S-Methylcysteine	Reactive Oxygen Species	Alkaloids Acids and Aldehydes
S-Methyl-L-cysteine is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities.

HY-N0666C

L-Aspartic aicd sodium Sodium L-aspartate	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Aspartic aicd sodium is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

HY-N0390

L-Glutamine L-Glutamic acid 5-amide	mGluR Endogenous Metabolite Ferroptosis	Alkaloids Acids and Aldehydes
L-Glutamine is a non-essential amino acid present abundantly throughout the body and is involved in gastrointestinal disorders.

HY-100385

Brevianamide F Cyclo(L-Pro-L-Trp)	PI3K Bacterial	Alkaloids
Brevianamide F (Cyclo(L-Pro-L-Trp)) is a mycotoxin isolated from Colletotrichum gloeosporioides, with antibacterial activity. Brevianamide F shows potent PI3Kα inhibitory activity with an IC₅₀ of 4.8 µM.

HY-N1480

(-)-Fucose 6-Desoxygalactose; L-(-)-Fucose; L-Galactomethylose	Endogenous Metabolite Parasite	Natural Products
(-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interactions.

HY-15121

L-Theanine L-Glutamic Acid γ-ethyl amide; Nγ-Ethyl-L-glutamine	Apoptosis	Alkaloids Acids and Aldehydes
L-Theanine (L-Glutamic Acid γ-ethyl amide）is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective and anti-oxidative activities. L-Theanine causes anti-stress effects via the inhibition of cortical neuron excitation by oral intake.

HY-W040088

L-Alanyl-L-leucine
H-Ala-Leu-OH
Endogenous Metabolite Natural Products

L-Alanyl-L-leucine is an endogenous metabolite.

HY-N1914

Ergothioneine L-(+)-Ergothioneine	Endogenous Metabolite	Alkaloids
Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant.

HY-W009208

Calcium L-Threonate	Endogenous Metabolite	Acids and Aldehydes
Calcium L-Threonate is an anti-osteoporosis agent, and widely used as a calcium supplement. Calcium L-Threonate also stimulates the uptake of ascorbic acid.

HY-N1368B

(-)-Borneol
L-Borneol
GABA Receptor Terpenoids and Glycosides

(-)-Borneol has a highly efficacious positive modulating action at GABA receptor with an EC₅₀ of 237 μM.
HY-B0399

L-Carnitine
Levocarnitine
Endogenous Metabolite Natural Products

L-carnitine (Levocarnitine) is constituent of striated muscle and liver.

HY-N1420

Rhamnose L-Rhamnose	Endogenous Metabolite	Saccharides and Glycosides
Rhamnose (L-Rhamnose) is a monosaccharide found in plants and bacteria. Rhamnose-conjugated immunogens is used in immunotherapies. Rhamnose crosses the epithelia via the transcellular pathway and acts as a marker of intestinal absorption.

HY-W016077

Glycyl-L-leucine
Others Acids and Aldehydes

Glycyl-l-leucine is a dipeptide that can be a common substrate for glycyl-leucine dipeptidase.
HY-W011393

L-Anserine nitrate
Endogenous Metabolite Natural Products

L-Anserine nitrate is an endogenous metabolite.

HY-W017018

L-Ornithine hydrochloride	Endogenous Metabolite	Acids and Aldehydes
L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.

HY-W016785

Glycyl-L-valine
Endogenous Metabolite Acids and Aldehydes

Glycyl-L-valine is a dipeptide that contains glycine and valine.

HY-W017443

L-Asparagine monohydrate	Endogenous Metabolite	Acids and Aldehydes
L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-W016443

L-m-Tyrosine
Others Acids and Aldehydes

L-m-Tyrosine is an unnatural amino acid, that has potential in the research of Parkinsons disease, Alzheimers disease, and arthritis.

HY-76082

L-Pyroglutamic acid	Endogenous Metabolite	Acids and Aldehydes
L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.

HY-B1581A

L-Canavanine sulfate
NO Synthase Natural Products

L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.

HY-113377

L-Glyceric acid	Endogenous Metabolite	Acids and Aldehydes
L-Glyceric acid is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid excretion to distinguish PH1 from PH2.

HY-N0471

L-Hyoscyamine
Daturine
mAChR Alkaloids

L-Hyoscyamine is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine.
HY-W015495

L-Dihydroorotic acid
Endogenous Metabolite Acids and Aldehydes

L-Dihydroorotic acid can reversibly hydrolyze to yield the acyclic L-ureidosuccinic acid by dihydrowhey enzyme.

HY-113165

Isobutyryl-L-carnitine	Endogenous Metabolite	Natural Products
Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases. Isobutyryl-L-carnitine is a member of the class of compounds known as acyl carnitines.

HY-N0666

L-Aspartic acid
Endogenous Metabolite Alkaloids Acids and Aldehydes

L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

HY-N2573

Corydalmine L-Corydalmine	Fungal CXCR	Alkaloids
Corydalmine (L-Corydalmine), an alkaloid isolated from roots of Corydalis Chaerophylla, inhibits spore germination of some plant pathogenic as well as saprophytic fungi. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway.

HY-126085

(±)-Alliin
(±)-L-Alliin
SARS-CoV Acids and Aldehydes

(±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of SARS-CoV-2 (M_pro).

HY-Y0337A

L-Cysteine hydrochloride	Endogenous Metabolite	Acids and Aldehydes
L-Cysteine hydrochloride is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents and humans.

HY-N0470

L-Lysine hydrochloride	Virus Protease	Alkaloids Acids and Aldehydes
L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

HY-112234

L-Sepiapterin Sepiapterin	Endogenous Metabolite	Natural Products
L-Sepiapterin (Sepiapterin) is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70^S6K-dependent VEGFR-2 expression.

HY-N1765

L-Praziquanamine
(+)-Praziquanamine
Others Alkaloids

L-Praziquanamine is a natural product.
HY-W048838

Acetyl-L-lysine
Endogenous Metabolite Acids and Aldehydes

Acetyl-L-lysine is an endogenous metabolite.
HY-W012161

Alanylphenylalanine
L-Alanyl-L-phenylalanine; H-Ala-Phe-OH
Endogenous Metabolite Natural Products

Alanylphenylalanine is an endogenous metabolite.

HY-13718

Oglufanide H-Glu-Trp-OH; L-Glutamyl-L-tryptophan	VEGFR HCV Endogenous Metabolite	Acids and Aldehydes
Oglufanide inhibits vascular endothelial growth factor (VEGF), which may inhibit angiogenesis.

HY-I1060

L-Alloisoleucine (3R)-LS-Isoleucine; L-Allo-isoleucine	Endogenous Metabolite	Natural Products
L-Alloisoleucine is a branched chain amino acid and is a stereo-isomer of L-isoleucine. L-Alloisoleucine is a common constituent of human plasma (albeit at low levels).

HY-B0762

Acetyl-L-carnitine hydrochloride O-Acetyl-L-carnitine (hydrochloride)	Endogenous Metabolite	Natural Products
Acetyl-L-carnitine hydrochloride is a blood-brain permeable acetyl ester of the amino acid L-carnitine found in the body. Acetyl-L-carnitine hydrochloride is often used as a dietary supplement, and exibits anti-stress-related psychiatric disorders.

HY-B0166A

L-Ascorbic acid sodium salt (+)-Sodium L-ascorbate; Vitamin C sodium salt; Sodium L-ascorbate	Reactive Oxygen Species Apoptosis	Natural Products
L-Ascorbic acid sodium salt is a more bioavailable form of vitamin C that is an antioxidant agent.

HY-B0447A

L-Epinephrine Bitartrate (-)-Epinephrine (+)-bitartrate salt; L-Adrenaline (+)-bitartrate salt	Adrenergic Receptor	Phenols
L-Epinephrine bitartrate is an α-adrenergic and β-adrenergic receptor agonist. L-Epinephrine is a hormone secreted by the medulla of the adrenal glands.

HY-W041171

3-Chloro-L-tyrosine	Endogenous Metabolite	Phenols Acids and Aldehydes
3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.

HY-N0642

α-L-Rhamnose monohydrate	Others	Saccharides and Glycosides
α-L-Rhamnose monohydrate is a component of the plant cell wall pectic polysaccharides rhamnogalacturonan I and rhamnogalacturonan II. α-L-Rhamnose monohydrate is also a component of bacterial polysaccharides where it plays an important role in pathogenicity.

HY-N0096

Rotundine (-)-Tetrahydropalmatine; L-Tetrahydropalmatine	5-HT Receptor Dopamine Receptor	Alkaloids
Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC₅₀s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of 5-HT_1A with an IC₅₀ of 370 nM.

HY-102015

6-Biopterin
L-Biopterin
NO Synthase Endogenous Metabolite Alkaloids

6-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor.
HY-W011978

N-Acetyl-L-tryptophan
Endogenous Metabolite Acids and Aldehydes

N-Acetyl-L-tryptophan is an endogenous metabolite.
HY-W017006

1-Methyl-L-histidine
Endogenous Metabolite Natural Products

1-Methyl-L-histidine is an objective indicator of meat ingestion and exogenous 3-methylhistidine (3MH) intake.
HY-113248

3-Nitro-L-tyrosine
Endogenous Metabolite Natural Products

3-Nitro-L-tyrosine is a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions.
HY-W016480

4-Amino-L-phenylalanine
Endogenous Metabolite Natural Products

4-Amino-L-phenylalanine is an endogenous metabolite.

HY-N0623

L-Tryptophan Tryptophan; Tryptophane	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3.

HY-W013573

S-Allyl-L-cysteine	Apoptosis	Alkaloids Acids and Aldehydes
S-Allyl-L-cysteine, one of the organosulfur compounds found in AGE, possess various biological effects including neurotrophic activity, anti-cancer activity, anti-inflammatory activity.

HY-N5001

Euphorbia Factor L2	Apoptosis	Terpenoids and Glycosides
Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed (the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. Euphorbia factor L2 shows potent cytotoxicity and induces apoptosis via a mitochondrial pathway.

HY-W012382

N-Acetyl-L-tyrosine	Endogenous Metabolite	Alkaloids Phenols Acids and Aldehydes
N-Acetyl-L-tyrosine originates from tyrosine through an AA acetylase, is associated with aromatic L-amino acid decarboxylase deficiency and tyrosinemia I.

HY-13715

Norepinephrine Levarterenol; L-Noradrenaline	Endogenous Metabolite Adrenergic Receptor Autophagy	Phenols
Norepinephrine (Levarterenol; L-Noradrenaline) is a β₁-selective adrenergic receptor agonist with EC₅₀ of 5.37 μM.

HY-113426

Nepsilon-Acetyl-L-lysine
Endogenous Metabolite Acids and Aldehydes

Nepsilon-Acetyl-L-lysine is a derivative of the amino acid lysine.

HY-W017007

3-Methyl-L-histidine	Endogenous Metabolite	Natural Products
3-Methyl-L-histidine is a biomarker for meat consumption, especially chicken. It is also a biomarker for the consumption of soy products.

HY-N0455

L-Arginine (S)-(+)-Arginine	NO Synthase Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-59291

N-Acetyl-L-leucine
Endogenous Metabolite Acids and Aldehydes

N-Acetyl-L-leucine is an endogenous metabolite.

HY-N2557

Euphorbia Factor L1	Apoptosis	Terpenoids and Glycosides
Euphorbia Factor L1 is a diterpenoid from Euphorbia lathyris L., reduces the expression of Bcl-2, PI3K, AKT and mTOR protein and mRNA, upregulates cleaved caspase-9 and caspase-3 levels, buts shows no effect on pro-caspase-9 and pro-caspase-3. Euphorbia Factor L1 induces apoptosis, has anticancer, antiadipogenesis, antiosteoclastogenesis and multidrug resistance-modulating effect.

HY-113377A

L-Glyceric acid sodium	Endogenous Metabolite	Acids and Aldehydes
L-Glyceric acid sodium is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid sodium can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid sodium excretion to distinguish PH1 from PH2.

HY-14596

Genistein NPI 031L	EGFR Autophagy Apoptosis Endogenous Metabolite	Flavonoids
Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.

HY-107837

2-Phospho-L-ascorbic acid trisodium L-Ascorbic acid 2-phosphate trisodium	c-Met/HGFR Reactive Oxygen Species Endogenous Metabolite	Natural Products
2-Phospho-L-ascorbic acid trisodium acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production.

HY-113468A

3-O-Methyldopa 3-Methoxy-L-tyrosine; 3-O-Methyl-L-DOPA	Dopamine Receptor Endogenous Metabolite	Natural Products
3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine.

HY-14520

Tetrahydrofolic acid L-5,6,7,8-Tetrahydrofolic acid; L-Tetrahydrofolic acid	Endogenous Metabolite	Natural Products
Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid.

HY-17490

Oxaceprol
N-Acetyl-L-hydroxyproline
Others Acids and Aldehydes

Oxaceprol is an anti-inflammatory drug used in the treatment of osteoarthritis.

HY-N0667

L-Asparagine (-)-Asparagine; Asn; Asparamide	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N0471A

L-Hyoscyamine sulfate Daturine sulfate	mAChR	Alkaloids
L-Hyoscyamine sulfate (Daturine sulfate) is a tropane alkaloid that is a secondary metabolite found in certain plants of the solanaceae family. In vitro it has been shown to be an antagonist of mAChR.

HY-W008646

7,8-Dihydro-L-biopterin
Endogenous Metabolite Natural Products

7,8-Dihydro-L-biopterin is an oxidation product of tetrahydrobiopterin.
HY-W014130A

N-Acetyl-L-arginine dihydrate
Endogenous Metabolite Natural Products

N-Acetyl-L-arginine (dihydrate) is an endogenous metabolite.

HY-W016628

L-Gulono-1,4-lactone	Endogenous Metabolite	Natural Products
L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.

HY-N1420A

Rhamnose monohydrate L-Rhamnose monohydrate	Others	Saccharides and Glycosides
Rhamnose monohydrate (L-Rhamnose monohydrate) is a monosaccharide found in plants and bacteria. Rhamnose monohydrate-conjugated immunogens is used in immunotherapies. Rhamnose monohydrate crosses the epithelia via the transcellular pathway and acts as a marker of intestinal absorption.

HY-111827

S-1-Propenyl-L-cysteine	Others	Natural Products
S-1-Propenyl-L-cysteine is a stereoisomer of S-allyl-l-cysteine, extracted from garlic, with immunomodulatory effects and reduces blood pressure in a hypertensive animal model.

HY-N0650

L-Serine (-)-Serine; (S)-Serine	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-W014180

N-Acetyl-L-histidine monohydrate	Endogenous Metabolite	Acids and Aldehydes
N-Acetyl-L-histidine monohydrate, a histidine derivative, is a prominent biomolecule in brain, retina and lens of poikilothermic vertebrates. N-Acetyl-L-histidine monohydrate has a role as an animal metabolite.

HY-W050044

L-Azetidine-2-carboxylic acid
Endogenous Metabolite Acids and Aldehydes

L-Azetidine-2-carboxylic acid is an endogenous metabolite.

HY-18341

L-Thyroxine Levothyroxine; T4	Thyroid Hormone Receptor Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Thyroxine (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

HY-N0225

(-)-Epigallocatechin Epigallocatechin; EGC; L-Epigallocatechin	MMP Autophagy	Flavonoids
(-)-Epigallocatechin (EGC) is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils.

HY-W015240

N-Acetyl-L-glutamic acid	Endogenous Metabolite	Natural Products
N-Acetyl-L-glutamic acid, a N-acyl-L-amino acid, is a component of animal cell culturing media. N-Acetyl-L-glutamic acid is a metabolite of Saccharomyces cerevisiae and human.

HY-N0406

2"-O-beta-L-galactopyranosylorientin	Others	Flavonoids
2"-O-beta-L-galactopyranosylorientin is extracted from the flowers of Trollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate of multidrug resistance protein 2 (MRP2).

HY-113524

N-Acetyl-L-aspartic acid
Endogenous Metabolite Alkaloids Acids and Aldehydes

N-Acetyl-L-aspartic acid is a derivative of aspartic acid.
HY-101409A

O-Acetyl-L-serine hydrochloride
Endogenous Metabolite Acids and Aldehydes

O-Acetyl-L-serine hydrochloride is an endogenous metabolite.

HY-32291

Methyl L-pyroglutamate (S)-Methyl 5-oxopyrrolidine-2-carboxylate; L-Pyroglutamic acid methyl ester	Others	Alkaloids
Methyl L-pyroglutamate ((S)-Methyl 5-oxopyrrolidine-2-carboxylate;L-Pyroglutamic acid methyl ester) is isolated from P. oleracea and has anti-inflammatory activity.

HY-D0844

Glutathione oxidized L-Glutathione oxidized; GSSG	Endogenous Metabolite Reactive Oxygen Species	Alkaloids Acids and Aldehydes
Glutathione oxidized is produced by the oxidation of glutathione which is a major intracellular antioxidant and detoxifying agent.

HY-13458

Droxidopa L-DOPS; DOPS; SM5688	Others	Phenylpropanoids
Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood–brain barrier.

HY-N0666B

Aspartic acid calcium Calcium L-aspartate	Others	Alkaloids Acids and Aldehydes
Aspartic acid calcium (Calcium L-aspartate) is a chelate where calcium is attached to an amino acid naming L-Aspartic acid. L-Aspartic acid is an amino acid and serves as a building block for proteins in the body.

HY-B2246

L-Carnitine hydrochloride (R)-Carnitine hydrochloride	Endogenous Metabolite	Acids and Aldehydes
L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism.

HY-101409

O-Acetylserine O-Acetyl-L-serine	Endogenous Metabolite	Alkaloids Acids and Aldehydes
O-Acetylserine (O-Acetyl-L-serine) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants.

HY-W012499

N-Acetyl-L-methionine N-Acetylmethionine	Endogenous Metabolite	Natural Products
N-Acetyl-L-methionine, a human metabolite, is nutritionally and metabolically equivalent to L-methionine. L-methionine is an indispensable amino acid required for normal growth and development.

HY-N6858

4-Hydroxyisoleucine 4-Hydroxy-L-isoleucine	Others	Natural Products
4-Hydroxyisoleucine (4-Hydroxy-L-isoleucine) is an amino acid which can be extracted and purified from fenugreek seeds. 4-Hydroxyisoleucine (4-Hydroxy-L-isoleucine) displays an insulinotropic activity of great interest.

HY-N4112

L-Fucitol
1-Deoxy-D-galactitol
Others Natural Products

L-Fucitol (1-Deoxy-D-galactitol) is a sugar alcohol isolated from Nutmeg.

HY-N0455A

L-Arginine hydrochloride (S)-(+)-Arginine hydrochloride	NO Synthase Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-14608

(S)-Glutamic acid (+)-L-Glutamic acid	Endogenous Metabolite iGluR Ferroptosis Apoptosis	Alkaloids Acids and Aldehydes
(S)-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-W008315

L-Allothreonine
H-allo-Thr-OH
Endogenous Metabolite Acids and Aldehydes

L-Allothreonine (H-allo-Thr-OH) is an endogenous metabolite.

HY-N0304

L-DOPA Levodopa; 3,4-Dihydroxyphenylalanine	Dopamine Receptor Endogenous Metabolite	Alkaloids
L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease.

HY-B0225

L-(-)-α-Methyldopa MK-351; Methyldopa	Adrenergic Receptor	Natural Products
Methyldopa is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.

HY-N2042

Cimigenol-3-O-α-L-arabinoside
Others Saccharides and Glycosides Terpenoids and Glycosides

Cimigenol-3-O-α-L-arabinoside is a triterpenoid isolated from Cimicifuga foetida L.

HY-W050031

(S)-3-Hydroxybutanoic acid (S)-β-Hydroxybutanoic acid; L-(+)-3-Hydroxybutyric acid; L-β-Hydroxybutyric acid	Endogenous Metabolite	Acids and Aldehydes
(S)-3-Hydroxybutanoic acid is a normal human metabolite, that has been found elevated in geriatric patients remitting from depression. In humans, 3-Hydroxybutyric acid is synthesized in the liver from acetyl-CoA, and can be used as an energy source by the brain when blood glucose is low.

HY-N2310

Domoic acid (-)-Domoic acid; L-Domoic acid	iGluR	Acids and Aldehydes
Domoic acid ((-)-Domoic acid; L-Domoic acid) is an excitatory neurotransmitter isolated from a form of marine vegetation, Nitzschia pungens. Domoic acid produces neurotoxic effect through activating kainate receptor.

HY-W010104

L-Methionine sulfoxide H-Met(O)-OH	Endogenous Metabolite	Acids and Aldehydes
L-Methionine sulfoxide (H-Met(O)-OH), a metabolite of Methionine, induces M1/classical macrophage polarization, and modulates oxidative stress and purinergic signaling parameters.

HY-14608A

L-Glutamic acid monosodium salt Monosodium glutamate	iGluR Apoptosis Ferroptosis	Alkaloids Acids and Aldehydes
L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-N7132

Menthyl acetate L-Menthyl acetate; (-)-Menthyl acetate	Others	Natural Products
Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation.

HY-B1352

L-Ornithine (S)-2,5-Diaminopentanoic acid	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-ornithine has an antifatigue effect in increasing the efficiency of energy consumption and promoting the excretion of ammonia.

HY-Y0479

L-Lactic acid (S)-2-Hydroxypropanoic acid	Bacterial Endogenous Metabolite Antibiotic	Acids and Aldehydes
L-Lactic acid is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid.

HY-B0979

Lobeline hydrochloride α-Lobeline hydrochloride; L-Lobeline hydrochloride	nAChR	Alkaloids
Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes.

HY-Y0017

L-Norleucine (S)-Norleucine; (S)-2-Aminohexanoic acid	Influenza Virus Endogenous Metabolite	Acids and Aldehydes
L-Norleucine is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

HY-128420

Lobeline sulfate α-Lobeline sulfate; L-Lobeline sulfate	Endogenous Metabolite	Alkaloids
Lobeline sulfate (α-Lobeline sulfate; L-Lobeline sulfate) is a nonstimulant medication that can alter dopamine uptake in brain. Lobeline sulfate (α-Lobeline sulfate; L-Lobeline sulfate) inhibits nicotine-induced hyperactivity and is effective in smoking cessation.

HY-101410

SDMA Symmetric dimethylarginine; NG,NG'-Dimethyl-L-arginine	Endogenous Metabolite	Alkaloids Acids and Aldehydes
SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity.

HY-W050026

Phenylacetylglutamine NSC 203800; Phenylacetyl-L-glutamine	Endogenous Metabolite	Acids and Aldehydes
Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation.

HY-113039

L-2-Hydroxyglutaric acid (S)-2-Hydroxyglutaric acid	Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite	Acids and Aldehydes
L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with K_m and K_i of 2.52 mM and 11.13 mM, respectively.

HY-B0215

Acetylcysteine N-Acetylcysteine; N-Acetyl-L-cysteine; NAC	Reactive Oxygen Species Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus	Alkaloids Acids and Aldehydes
Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities.

HY-B0471

Phenylephrine hydrochloride (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride	Adrenergic Receptor Endogenous Metabolite	Natural Products
(R)-(-)-Phenylephrine hydrochloride is a selective α₁-adrenoceptor agonist with pK_is of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

HY-N0457A

L-Chicoric Acid (-)-Chicoric acid; trans-Caffeoyltartaric acid	HIV Integrase HIV	Phenylpropanoids
L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC₅₀ of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture.

HY-10572

Efavirenz DMP 266; EFV; L-743726	Reverse Transcriptase HIV Autophagy	Alkaloids
Efavirenz is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅ of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture.

HY-113025A

L-hydroxylysine dihydrochloride (2S,5R)-5-Hydroxylysine dihydrochloride	Endogenous Metabolite	Acids and Aldehydes
L-hydroxylysine dihydrochloride ((2S,5R)-5-Hydroxylysine dihydrochloride), an amino acid, is exclusive to collagen protein, which is formed by posttranslational hydroxylation of some lysine residues.

HY-N0215

L-Phenylalanine (S)-2-Amino-3-phenylpropionic acid	Calcium Channel iGluR Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca⁺ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (K_B of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.

HY-111825

1-PeCSO S-1-Propenyl-L-cysteine sulfoxide	Others	Natural Products
1-PeCSO is isolated from onion or garlic bulbs, acts as a key compound in garlic greening, and reacts with lachrymatory factor synthase.

HY-B1065

Aceglutamide α-N-Acetyl-L-glutamine; N2-Acetylglutamine	Autophagy Endogenous Metabolite	Natural Products
Aceglutamide (α-N-Acetyl-L-glutamine) is a psychostimulant and nootropic, used to improve memory and concentration.

HY-114557

NSC 90469
3,5-Diiodo-L-thyronine
Endogenous Metabolite Acids and Aldehydes

NSC 90469 is an endogenous metabolite.

HY-B1122

L-Cycloserine (S)-Cycloserine; (S)-4-Amino-3-isoxazolidone	GABA Receptor HIV	Alkaloids
L-Cycloserine ((S)-4-Amino-3-isoxazolidone) irreversibly inhibits GABA pyridoxal 5′-phosphate-dependent aminitransferase in E.

HY-N0562

5,15-Diacetyl-3-benzoyllathyrol
Euphorbia factor L3
Others Terpenoids and Glycosides

5,15-Diacetyl-3-benzoyllathyrol is one of the lathyrane diterpenoids, that has anti-cancer activity.

HY-B0617

S-Adenosyl-L-methionine Ademetionine; S-Adenosyl methionine; AdoMet	Endogenous Metabolite	Natural Products
S-Adenosyl-L-methionine (Ademetionine) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research.

HY-13715B

Norepinephrine bitartrate monohydrate Levarterenol bitartrate monohydrate; L-Noradrenaline bitartrate monohydrate	Adrenergic Receptor Autophagy	Natural Products
Norepinephrine bitartrate monohydrate (Levarterenol bitartrate monohydrate; L-Noradrenaline bitartrate monohydrate) is a β₁-selective adrenergic receptor agonist with EC₅₀ of 5.37 μM.

HY-N4310

Taxifolin 7-O-rhamnoside
Taxifolin 7-O-α-L-rhamnoside
Others Flavonoids

Taxifolin 7-O-rhamnoside (Taxifolin 7-O-α-L-rhamnoside) is a flavonoid isolated from Hypericum japonicum.
HY-Y0068

NSC 45699
N-Acetyl-L-phenylalanine; N-Acetylphenylalanine
Endogenous Metabolite Acids and Aldehydes

NSC 45699 is an endogenous metabolite.

HY-A0070A

Liothyronine Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Thyroid Hormone Receptor Endogenous Metabolite	Alkaloids Phenols Acids and Aldehydes
Liothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.

HY-A0124A

Sapropterin dihydrochloride 6R-BH4 dihydrochloride; 6R-Tetrahydro-L-biopterin dihydrochloride	Others	Alkaloids
Sapropterin dihydrochloride is a synthetic form of BH4 that is approved for the treatment of BH4 responsive PKU.

HY-N2174

Ophiogenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside	Others	Steroids
Ophiogenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside, a terpenoid glycoside from Ophiopogon japonicus roots, has good pharmacological effects on the cardiovascular system.

HY-N6958

2-O-β-D-Glucopyranosyl-L-ascorbic acid AA-2βG	Others	Acids and Aldehydes Saccharides and Glycosides
2-O-β-D-Glucopyranosyl-L-ascorbic acid (AA-2βG), isolated from Lycium Fruit, is a stable vitamin C analog with anti-tumor activity.

HY-N5128

Apigenin6-C-α-L-arabinopyranosyl-8-C-β-D-xylopyranoside
Others Flavonoids

Apigenin6-C-α-L-arabinopyranosyl-8-C-β-D-xylopyranoside is a natural flavanone compound.

HY-17552

sn-Glycero-3-phosphocholine Choline Alfoscerate; Alpha-GPC; L-α-GPC	AChE Endogenous Metabolite	Natural Products
sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. sn-Glycero-3-phosphocholine (Choline Alfoscerate) has significant effects on cognitive function with a good safety profile and tolerability, and is effective in the treatment of Alzheimer's disease and dementia.

HY-W018035

DL-Glyceric Acid Glyceric Acid (20% in Water,ca.2 mol/L)	Endogenous Metabolite	Natural Products
DL-Glyceric Acid is a compound that is secreted excessively in the urine by patients suffering from D-glyceric aciduria.

HY-12686

5Z-7-Oxozeaenol FR148083; L783279; LL-Z 1640-2	MAP3K VEGFR	Natural Products
5Z-7-Oxozeaenol is a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC₅₀s of 8 nM and 52 nM, respectively.

HY-B0617A

S-Adenosyl-L-methionine tosylate Ademetionine tosylate; S-Adenosyl methionine tosylate; AdoMet tosylate	Endogenous Metabolite	Natural Products
S-Adenosyl-L-methionine tosylate (Ademetionine tosylate) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research.

HY-N6964

Quercetin 3-O-β-D-(6''-p-coumaroyl)glucopyranosyl(1→2)-α-L-rhamnopyranoside Quercetin-3-O-[2-O-(6-O-p-hydroxyl-E-coumaroyl)-D-glucosyl]-(1→2)-L-rhamnoside	Others	Flavonoids
Quercetin 3-O-β-D-(6''-p-coumaroyl)glucopyranosyl(1→2)-α-L-rhamnopyranoside (Quercetin-3-O-[2-O-(6-O-p-hydroxyl-E-coumaroyl)-D-glucosyl]-(1→2)-L-rhamnoside) is one of the major antioxidants of Ginkgo biloba leaves.

HY-N7404

Nε,Nε,Nε-Trimethyllysine chloride Ne-(Trimethyl)-L-lysine chloride; H-Lys(Me)3-OH chloride	Endogenous Metabolite	Acids and Aldehydes
Nε,Nε,Nε-Trimethyllysine chloride serves as a precursor for gut flora-dependent formation of N,N,N-trimethyl-5-aminovaleric acid (TMAVA).

HY-W010271

(2S,3R,4S)-4-Hydroxyisoleucine (2S,3R,4S)-4-Hydroxy-L-isoleucine	Others	Natural Products
(2S,3R,4S)-4-Hydroxyisoleucine is an orally active compound isolated from Trigonella foenum-graecum, with anti-diabetes and anti-diabetic nephropathy activity.

Cat. No.	Product Name	Species	Source

HY-P7446

*Recombinant Mouse 4-1BB* Ligand/TNFSF9, His (HEK293-expressed)** rMu4-1BB Ligand/TNFSF9, His; 4-1BBL; CD137L; 4-1BB Ligand; TNFSF9	Mouse	HEK 293
Recombinant Mouse 4-1BB Ligand/TNFSF9, His (HEK293-expressed) is a member of the tumor necrosis factor (TNF) superfamily and is the ligand for the TNFR superfamily receptor 4-1BB, with an N-terminal His tag^[1].

HY-P7113

*Recombinant Human 4-1BB* Ligand/TNFSF9** rHu4-1BBL/TNFSF9; CD137L	Human	E. coli
Recombinant Human 4-1BB Ligand/TNFSF9 is a costimulatory member of the TNF family, which are expressed on activated B cells, macrophages, and dendritic cells.

HY-P7317

*Recombinant Human 4-1BB, Fc Chimera (CHO-expressed)* rHu4-1BB, Fc Chimera; CD137; ILA	Human	CHO
Recombinant Human 4-1BB, Fc Chimera (CHO-expressed) is a polypeptide chain with the C-termimal human IgG1 Fc fragment produced in CHO. 4-1BB is a member of the tumor necrosis factor receptor superfamily.

HY-P7447

*Recombinant Mouse 4-1BB/TNFRSF9, C-Fc (HEK293-expressed)* rMu4-1BB/TNFRSF9, C-Fc; CD137; 4-1 BB; TNFRSF-9	Mouse	HEK 293
Recombinant Mouse 4-1BB/TNFRSF9, C-Fc (HEK293-expressed) also known as CD137, is an inducible costimulatory receptor and a specific target for cancer therapy^[1].

HY-P7424

Recombinant Human RANK L/TNFSF11 rHuRANK L/TNFSF11; TRANCE; CD254	Human	E. coli
Recombinant Human RANK L/TNFSF11 is a TNF-related activation-induced cytokine produced in E. coli. Recombinant Human RANK L/TNFSF11 induces the activation of the c-jun N terminal kinase, enhances T cell growth and dendritic cell function, induces osteoclastogenesis, and lymph node organogenesis.

HY-P7425

Recombinant Mouse RANK L/TNFSF11 rMuRANK L/TNFSF11; TRANCE; CD254	Mouse	E. coli
Recombinant Mouse RANK L/TNFSF11 is a TNF-related activation-induced cytokine produced in E. coli. Mouse and human RANK Ligand share 85% amino acid identity. Recombinant Mouse RANK L/TNFSF11 induces the activation of the c-jun N terminal kinase, enhances T cell growth and dendritic cell function, induces osteoclastogenesis, and lymph node organogenesis.

HY-P7306

Recombinant Human TRAIL/Apo2L rHuTRAIL/Apo2L; TNFSF10; CD253	Human	E. coli
Recombinant Human TRAIL/Apo2L is a protein functioning as a ligand that induces the process of apoptosis through engagement of death receptors.

HY-P7425A

Recombinant Mouse RANK L/TNFSF11, His (CHO-expressed) rMuRANK L/TNFSF11, His; TRANCE; CD254	Mouse	CHO
Recombinant Mouse RANK L/TNFSF11,His (CHO-expressed) is a TNF-related activation-induced cytokine produced in CHO. Mouse and human RANK Ligand share 85% amino acid identity. Recombinant Mouse RANK L/TNFSF11,His (CHO-expressed) induces the activation of the c-jun N terminal kinase, enhances T cell growth and dendritic cell function, induces osteoclastogenesis, and lymph node organogenesis.

HY-P7144

Recombinant Human CD40 Ligand rHuCD40L; CD154; TRAP; TNFSF5; CD40LG; CD40-L	Human	E. coli
Recombinant Human CD40 Ligand exerts an important role in immune system regulation, including myeloid progenitor cell development.

HY-P7231

Recombinant Human LD78 beta/CCL3L1 rHuLD78β/CCL3L1; C-C motif chemokine 3-like 1; SCYA3L1	Human	E. coli
Recombinant Human LD78 beta/CCL3L1 is a potent ligand for the HIV-1 co-receptor CCR5, which is essential for viral entry into human host cells.

HY-P7398

Recombinant Human PD-L1, His (HEK293-expressed) rHuPD-L1, His; Programmed death ligand 1; CD274; B7-H1	Human	HEK 293
Recombinant Human PD-L1, His (HEK293-expressed) play a major role in suppressing the adaptive arm of immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis.

HY-P7397

Recombinant Human PD-L1, Fc Chimera (CHO-expressed) rHuPD-L1, Fc Chimera; Programmed death ligand 1; CD274; B7-H1	Human	CHO
Recombinant Human PD-L1, Fc Chimera (CHO-expressed) play a major role in suppressing the adaptive arm of immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis.

HY-P7399

Recombinant Human PD-L2, Fc Chimera (HEK293-expressed) rHuPD-L2, Fc Chimera; Programmed cell death 1 ligand 2; B7DC; CD273	Human	HEK 293
Recombinant Human PD-L2, Fc Chimera (HEK293-expressed), a second ligand for PD-1, interacts with PD-1 negatively regulates T cell proliferation, cytokine production and cytotoxic activity.

HY-P7457

Recombinant Human ACY3, His rHuACY3, His; N-acyl-aromatic-L-amino acid amidohydrolase; ACY-3	Human	E. coli
Recombinant Human ACY3, His is human recombinant ACY3 with a N-terminal His tag. Recombinant Human ACY3, His plays an important role in deacetylating mercapturic acids in kidney proximal tubules^[1]^[2].

HY-P7313

Recombinant Human VEGF-C (HEK293-expressed) rHuVEGF-C; Vascular endothelial growth factor C; Flt4-L; VRP	Human	HEK 293
Recombinant Human VEGF-C (HEK293-expressed) functions in lymphangiogenesis, where it acts on lymphatic endothelial cells (LECs) primarily via its receptor VEGFR-3 promoting survival, growth and migration.

HY-P7309

Recombinant Human TWEAK (CHO-expressed) rHuTWEAK; TNF-related weak inducer of apoptosis; TNFSF12; DR3LG; APO3L	Human	CHO
Recombinant Human TWEAK (CHO-expressed) could induce apoptosis via multiple pathways of cell death in a cell type-specific manner and promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis.

HY-P7394

Recombinant Human OX40/TNFRSF4, His (HEK293-expressed) rHuOX40/TNFRSF4, His; ACT35 antigen; CD134; TXGP1L	Human	HEK 293
Recombinant Human OX40/TNFRSF4, His (HEK293-expressed) activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Recombinant Human OX40/TNFRSF4, His (HEK293-expressed) promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis.

HY-P7590

Recombinant Human RANK L/TNFSF11 (CHO-expressed) rHuRANK L/TNFSF11; Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine; TRANCE; CD254; TNFSF11; OPGL; RANKL; TRANCE	Human	CHO

HY-P7111

Recombinant Human Fms-related Tyrosine Kinase 3 Ligand (CHO-expressed) rHuFlt-3 Ligand; Flt3 ligand; FL; SL cytokine; Flt-3L	Human	CHO
Recombinant Human Fms-related Tyrosine Kinase 3 Ligand (CHO-expressed) is a cytokine, which can promote the generation and differentiation of hematopoietic stem cells and their progenitor cells.

HY-P7575

Recombinant Human CD27/TNFRSF7 (CHO-expressed) rHuCD27/TNFRSF7; CD27 antigen; CD27L receptor; T-cell activation antigen CD27; T14; Tumor necrosis factor receptor superfamily member 7; CD27; TNFRSF7	Human	CHO

HY-P7565

Recombinant Human OX40/TNFRSF4 (CHO-expressed) rHuOX40/TNFRSF4; Tumor necrosis factor ligand superfamily member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; CD252; TNFSF4; TXGP1	Human	CHO

HY-P7576

Recombinant Human CD30/TNFRSF8 (CHO-expressed) rHuCD30/TNFRSF8; Tumor necrosis factor receptor superfamily member 8; CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD30; TNFRSF8; D1S166E	Human	CHO

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