Anti-Mouse 4-1BB/CD137 Antibody (3H3)
Based on 1 Customer Validation
Anti-Mouse 4-1BB/CD137 Antibody (3H3) is an anti-mouse 4-1BB/CD137 IgG2a κ agonistic monoclonal antibody. Anti-Mouse 4-1BB/CD137 Antibody (3H3) can effectively activate memory T cells and inhibit tumors by increasing Bcl-xL and granzyme B levels. Anti-Mouse 4-1BB/CD137 Antibody (3H3) can be used for research on cancer such as lymphoma and colon cancer.
For research use only. We do not sell to patients.
- Purity: 98.22%
- Molecular Weight:150 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Rat IgG2a kappa
Mouse
|
Bcl-xL |
Anti-Mouse 4-1BB/CD137 Antibody (3H3) (4 mg/kg, i.p., once every 2 days, for 3 dose) significantly inhibits tumor growth female BALB/c mice bearing CT26hEGFR tumors[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:5×105 E.G7 cells injected wild type C57BL/6 mice (6-10 weeks)[1]
-
Dosage:100 μg
-
Administration:Intraperitoneal injection (i.p.), on day 8 and 11
-
Result:Significantly inhibited tumor growth in 57% of mice.
-
Animal Model:1.5×106 CT26hEGFR cells injected female BALB/c mice (6 weeks)[2]
-
Dosage:4 mg/kg
-
Administration:Intraperitoneal injection (i.p.), once every 2 days, for 3 dose
-
Result:Regressed 91% of mouse tumors and induces long-term immune memory.
Significantly enlarged spleen and liver.
Caused monocyte infiltration and collagen deposition in the liver, pancreas, and lungs.
Significantly increased the levels of IFN-γ, IL-6, and TNF-α.
XP_850336.1
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
Product Image
in vivo 4-1BB stimulationin vitro 4-1BB stimulation
Chemical Information
-
Appearance Liquid
-
Molecular Weight 150 kDa
-
Color Colorless to light yellow
-
SMILES
[Anti-Mouse 4-1BB/CD137 Antibody (3H3)]
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (261 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
[1]. Lin GH, et al. Evaluating the cellular targets of anti-4-1BB agonist antibody during immunotherapy of a pre-established tumor in mice. PLoS One. 2010 Jun 8;5(6):e11003. [Content Brief]
[2]. Compte M, et al. A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity. Nat Commun. 2018 Nov 15;9(1):4809. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse 4-1BB/CD137 Antibody (3H3) Related Classifications
HY-P99119 Related Classifications
Powered by Bioz