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Results for "55224-94-7" in MCE Product Catalog:

Cat. No. Product Name Target Research Areas
  • HY-W014421

    TRP Channel Neurological Disease
    AP-18 is a potent and selective TRPA1 inhibitor. AP18 blocks activation of TRPA1 by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP18 reverses complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 attenuated 30 μM AITC-induced Yo-Pro uptake in a concentration-dependent manner, with an IC50 of 10.3 μM.