1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. AP-18

AP-18 

Cat. No.: HY-W014421
Handling Instructions

AP-18 is a potent and selective TRPA1 inhibitor. AP18 blocks activation of TRPA1 by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP18 reverses complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 attenuated 30 μM AITC-induced Yo-Pro uptake in a concentration-dependent manner, with an IC50 of 10.3 μM.

For research use only. We do not sell to patients.

AP-18 Chemical Structure

AP-18 Chemical Structure

CAS No. : 55224-94-7

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Description

AP-18 is a potent and selective TRPA1 inhibitor. AP18 blocks activation of TRPA1 by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP18 reverses complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 attenuated 30 μM AITC-induced Yo-Pro uptake in a concentration-dependent manner, with an IC50 of 10.3 μM[1][2][3].

IC50 & Target[3]

TRPA1

~3 μM (IC50)

In Vitro

At concentrations up to 50 μM, AP-18 is unable to appreciably block activation of TRPV1, TRPV2, TRPV3, TRPV4, or TRPM8. AP-18 reversibly blocks mouse TRPA1 responses to iodoacetamide (an irreversible cysteine-alkylating agent) in CHO cells assayed by ratiometric Ca2+ imaging. AP-18 also blocks cold- and mustard-oil-induced activation of mouse TRPA1. AP-18 blocks cinnamaldehyde-induced TRPA1 currents in excised patches from Xenopus oocytes[1].

In Vivo

AP18 (1 mM; injected in hindpaw of mice) significantly blocks cinnamaldehdye-induced but not capsaicin-induced nociceptive events, demonstrating efficacy and specificity[1].

Molecular Weight

209.67

Formula

C₁₁H₁₂ClNO

CAS No.

55224-94-7

SMILES

CC(/C(C)=C/C1=CC=C(Cl)C=C1)=N\O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AP-18AP18AP 18TRP ChannelTransient receptor potential channelshyperalgesiapaintransductiondorsalrootganglianervesnociceptiveInhibitorinhibitorinhibit

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AP-18
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HY-W014421
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