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Results for "864249-60-5" in MCE Product Catalog:

Cat. No. Product Name Target Research Area
  • HY-108642
    AMG-548

    p38 MAPK Casein Kinase Inflammation/Immunology
    AMG-548 is a potent, oral and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γand p38δ. AMG 548 is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM) . AMG-548 inhibits Wnt signaling by direcly inhibing Casein kinase 1 isoforms δ and ε.