N-acetylglucosaminidase

By Targets:	Endogenous Metabolite (2) Endothelin Receptor (1) Fluorescent Dye (1) Glucosylceramide Synthase (GCS) (1) Kisspeptin Receptor (3) NOD-like Receptor (NLR) (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Metabolic Disease (5)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70132

*Endo-β-N-acetylglucosaminidase* D** Endo D	Others	Metabolic Disease
Endo-β-N-acetylglucosaminidase D (Endo D), isolated from Streptococcus pneumoniae. Endo-β-N-acetylglucosaminidase D hydrolyzes Fc N-glycan of intact IgG antibodies after sequential removal of the sialic acid, galactose, and internal GlcNAc residues in the N-glycan. Endo-β-N-acetylglucosaminidase D possesses transglycosylation activity with sugar oxazoline as the donor substrate .

HY-E70135

*Endo-β-N-acetylglucosaminidase* F1** Endo F1	Others	Metabolic Disease
Endo-β-N-acetylglucosaminidase F1 (Endo F1) cleaves Asparagine-linked high mannose and some hybrid oligosaccharides .

HY-E70134

*Endo-β-N-acetylglucosaminidase* F3** Endo F3	Others	Metabolic Disease
Endo-β-N-acetylglucosaminidase D (Endo F3) cleaves free or Asparagine-linked triantennary oligosaccharides or α1-6 fucosylated biantennary oligosaccharides, as well as triamnnosyl chitobiose core structures .

HY-E70184

α-N-Acetylglucosaminidase EC:3.2.1.50; NAGLU; UFHSD 1	Glucosylceramide Synthase (GCS)	Others
α-N-Acetylglucosaminidase (EC:3.2.1.50; NAGLU; UFHSD 1) is a alpha-N-acetylglucosaminidase .

HY-P2999

Endo-β-N-acetylglucosaminidase ENGase	Endogenous Metabolite	Others
Endo-β-N-acetylglucosaminidase (ENGase) is cytosolic deglycosylating enzyme that hydrolyzes the N-linked oligosaccharides. Endo-β-N-acetylglucosaminidase can be used for glycan analysis on glycoproteins and preparation of precursors for glycosylated compounds, is often used in biochemical studies .

HY-E70131

Endo H, Streptomyces picatus Endo-β-N-acetylglucosaminidase H	Others	Metabolic Disease
Endo H, Streptomyces picatus (Endo-β-N-acetylglucosaminidase H), isolated from Streptomyces plicatus, hydrolyzes the central glycosidic bond of the β1, 4-di-N-acetylchitobiose core in asparagine-linked oligosaccharides .

HY-E70133

*Endo-β-N-acetylglucosaminidase* F2** Endo F2	Others	Metabolic Disease
Endo-β-N-acetylglucosaminidase F2 (Endo F2), a highly specific endoglycosidase, cleaves within the chitobiose core of asparagine-linked complex biantennary and high mannose oligosaccharides from glycoproteins and glycopeptides. Endo F2 cleaves biantennary glycans at a rate approximately 20 times greater than high mannose glycans. The activity of Endo F2 is identical on biantennary structures with and without core fucosylation. Endo F2 is not active on hybrid or tri- and tetra-antennary oligosaccharides .

HY-E70069

Endo S2, Streptococcus pyogenes	Others	Others
Endo-β-N-acetylglucosaminidase (Endo S2) is a key enzyme involved in the processing of free oligosaccharides in the cytosol. Endo-β-N-acetylglucosaminidase catalyzes hydrolysis of N-linked oligosaccharides .

HY-D1530

*4-Methylumbelliferyl-N-acetyl-α-D-glucosaminide*	Fluorescent Dye	Others
4-Methylumbelliferyl-N-acetyl-α-D-glucosaminide is a fluorogenic substrate for detecting α-N-acetylglucosaminidase .

HY-N7529

Siastatin B	Endogenous Metabolite	Others
Siastatin B is an effective broad-spectrum glycosidase inhibitor that can effectively inhibit the activities of sialidase, β-D-glucuronidase, *N-acetyl-glucosaminidase, β-glucuronidase, and human heparinase* .

HY-P1016

BQ-3020	Endothelin Receptor	Cardiovascular Disease
BQ-3020 is a selective endothelin receptor (ET_B receptor) agonist that displaces [ ¹²⁵I] ET-1 binding to ET_B receptors, with an IC₅₀ value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research ¹ ².

HY-P5544

M-TriDAP N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid	NOD-like Receptor (NLR)	Others
M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) is a NOD1/2 agoist and biological active peptide .

HY-P5544A

M-TriDAP TFA N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid TFA	NOD-like Receptor (NLR)	Others
M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) TFA is a NOD1/2 agoist and biological active peptide .

HY-P2161A

TAK-683 TFA	Kisspeptin Receptor	Cancer
TAK-683 TFA is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 TFA is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively . TAK-683 TFA depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer .

HY-P2161

TAK-683	Kisspeptin Receptor	Cancer
TAK-683 is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively . TAK-683 depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer .

HY-P2161B

TAK-683 acetate	Kisspeptin Receptor	Cancer
TAK-683 acetate is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 acetate is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively . TAK-683 acetate depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer .

Cat. No.	Product Name	Type

HY-D1530

*4-Methylumbelliferyl-N-acetyl-α-D-glucosaminide*	Fluorescent Dyes/Probes
4-Methylumbelliferyl-N-acetyl-α-D-glucosaminide is a fluorogenic substrate for detecting α-N-acetylglucosaminidase .

Cat. No.	Product Name	Type

HY-E70068

*Endo-β-N-acetylglucosaminidase* (Endo S)**	Biochemical Assay Reagents
Endo-β-N-acetylglucosaminidase (Endo S) is a family 18 glycosyl hydrolase secreted by Streptococcus pyogenes. Endo-β-N-acetylglucosaminidase (Endo S) exclusively hydrolyzes the β-1,4-di-N-acetylchitobiose core of the asparagine-linked complex-type glycan on Asn-297 of the γ-chains of IgG antibody .

HY-E70184

α-N-Acetylglucosaminidase

EC:3.2.1.50; NAGLU; UFHSD 1
Enzyme Substrates

α-N-Acetylglucosaminidase (EC:3.2.1.50; NAGLU; UFHSD 1) is a alpha-N-acetylglucosaminidase .

α-N-Acetylglucosaminidase EC:3.2.1.50; NAGLU; UFHSD 1	Enzyme Substrates
α-N-Acetylglucosaminidase (EC:3.2.1.50; NAGLU; UFHSD 1) is a alpha-N-acetylglucosaminidase .

HY-E70070

*Endo-β-N-acetylglucosaminidase* (Endo A)**	Biochemical Assay Reagents
Endo-β-N-acetylglucosaminidase (Endo A) is an Endo-β-N-acetylglucosaminidases (ENGases) from Arthrobacter protophormiae. Endo-β-N-acetylglucosaminidase (Endo A) can transfer a high-mannose type oligosaccharide to monosaccharides such as N-acetylglucosamine (GlcNAc) and glucose to form a new oligosaccharide. Endo-β-N-acetylglucosaminidase (Endo A) catalyzes glycopeptide synthesis by using Man3GlcNAc-oxazoline .

Endo-β-N-acetylglucosaminidase (Endo A)

Biochemical Assay Reagents

Endo-β-N-acetylglucosaminidase (Endo A) is an Endo-β-N-acetylglucosaminidases (ENGases) from Arthrobacter protophormiae. Endo-β-N-acetylglucosaminidase (Endo A) can transfer a high-mannose type oligosaccharide to monosaccharides such as N-acetylglucosamine (GlcNAc) and glucose to form a new oligosaccharide. Endo-β-N-acetylglucosaminidase (Endo A) catalyzes glycopeptide synthesis by using Man3GlcNAc-oxazoline .

HY-P2999

Endo-β-N-acetylglucosaminidase ENGase	Biochemical Assay Reagents
Endo-β-N-acetylglucosaminidase (ENGase) is cytosolic deglycosylating enzyme that hydrolyzes the N-linked oligosaccharides. Endo-β-N-acetylglucosaminidase can be used for glycan analysis on glycoproteins and preparation of precursors for glycosylated compounds, is often used in biochemical studies .

Cat. No.	Product Name	Target	Research Area

HY-P5544

M-TriDAP N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid	NOD-like Receptor (NLR)	Others
M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) is a NOD1/2 agoist and biological active peptide .

HY-P2999

Endo-β-N-acetylglucosaminidase ENGase	Endogenous Metabolite	Others
Endo-β-N-acetylglucosaminidase (ENGase) is cytosolic deglycosylating enzyme that hydrolyzes the N-linked oligosaccharides. Endo-β-N-acetylglucosaminidase can be used for glycan analysis on glycoproteins and preparation of precursors for glycosylated compounds, is often used in biochemical studies .

HY-P1016

BQ-3020	Endothelin Receptor	Cardiovascular Disease
BQ-3020 is a selective endothelin receptor (ET_B receptor) agonist that displaces [ ¹²⁵I] ET-1 binding to ET_B receptors, with an IC₅₀ value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research ¹ ².

HY-P5544A

M-TriDAP TFA N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid TFA	NOD-like Receptor (NLR)	Others
M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) TFA is a NOD1/2 agoist and biological active peptide .

HY-P2161A

TAK-683 TFA	Kisspeptin Receptor	Cancer
TAK-683 TFA is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 TFA is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively . TAK-683 TFA depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer .

HY-P2161

TAK-683	Kisspeptin Receptor	Cancer
TAK-683 is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively . TAK-683 depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer .

HY-P2161B

TAK-683 acetate	Kisspeptin Receptor	Cancer
TAK-683 acetate is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 acetate is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively . TAK-683 acetate depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer .

Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P79064

	Endo S2 Protein, S. pyogenes (His) Secreted Endo-beta-N-acetylglucosaminidase (EndoS); endoS; Spy49_1414c; Endo-beta-N-acetylglucosaminidase S2	Others	E. coli
	Endo S2, secreted by Streptococcus pyogenes, deglycosylates the conserved N-linked glycan at Asn297 on IgG Fc to eliminate its effector functions and evade the immune system. EndoS2 specifically hydrolyzes diverse glycans on the Fc region of IgG antibodies using a mechanism that relies on its glycoside hydrolase domain and a coevolved carbohydrate-binding module. Endo S2 Protein, S. pyogenes (His) is the recombinant Endo S2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Endo S2 Protein, S. pyogenes (His) is 807 a.a., with molecular weight of ~95 kDa.

HY-P79242

	O-GlcNAcase/OGA Protein, B. thetaiotaomicron (His) O-GlcNAcase BT_4395; Beta-N-acetylglucosaminidase; Beta-N-acetylhexosaminidase; Beta-hexosaminidase; Hexosaminidase B; N-acetyl-beta-glucosaminidase	Others	E. coli
	O-GlcNAcase (OGA) is an enzyme with the capability to hydrolyze the glycosidic link in O-GlcNAcylated proteins. In vitro, it demonstrates the ability to utilize substrates such as p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc. O-GlcNAcase/OGA Protein, B. thetaiotaomicron (His) is the recombinant O-GlcNAcase/OGA protein, expressed by E. coli , with N-6*His labeled tag. The total length of O-GlcNAcase/OGA Protein, B. thetaiotaomicron (His) is 716 a.a., with molecular weight of 80-95 kDa.


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Fluorescent Dye

Biochemical Assay Reagents

Peptides

Recombinant Proteins