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Results for "

Polθ

" in MedChemExpress (MCE) Product Catalog:

4

Inhibitors & Agonists

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-150279
    PolQi2

    		DNA/RNA Synthesis Others
    PolQi2 inhibits the helicase activity of Polθ. PolQi2 improves the precision of gene editing at various loci and in different cell lines .
    PolQi2
  • HY-145056
    ART615

    		Others Cancer
    ART615 is the related isomer of ART558. ART615, the inactive of ART558, elicits <10% Polθ inhibition at 12 µM, thus serving as a control for ART558 (IC50=7.9 nM) .
    ART615
  • HY-161302
    Polθ/PARP-IN-1

    		Apoptosis DNA/RNA Synthesis PARP Cancer
    Polθ/PARP-IN-1 (compound 25d) is a potent dual DNA polymerase theta (Polθ) and PARP inhibitor with IC50 values of 45.6, 5.4 nM, respectively. Polθ/PARP-IN-1 shows antiproliferative activity. Polθ/PARP-IN-1 induces apoptosis and cell cycle arrest at G2/M phase, causes DNA damage. Polθ/PARP-IN-1 shows anti-tumor activity .
    <em>Polθ</em>/PARP-IN-1
  • HY-139593S
    Polθ-IN-1-d3

    		Isotope-Labeled Compounds Cancer
    Polθ-IN-1-d3 (example 1) is a deuterated Polθ inhibitor used for cancer study (extracted from patent WO2021028670) .
    <em>Polθ</em>-IN-1-d3

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