1. Metabolic Enzyme/Protease
  2. Isocitrate Dehydrogenase (IDH)
  3. WT IDH1 Inhibitor 2

WT IDH1 Inhibitor 2 

Cat. No.: HY-128888
Handling Instructions

WT IDH1 Inhibitor 2 (Compound 3) is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. WT IDH1 Inhibitor 2 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity.

For research use only. We do not sell to patients.

WT IDH1 Inhibitor 2 Chemical Structure

WT IDH1 Inhibitor 2 Chemical Structure

CAS No. : 1816272-19-1

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Description

WT IDH1 Inhibitor 2 (Compound 3) is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. WT IDH1 Inhibitor 2 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity[1].

IC50 & Target

IC50: 120 nM (WT IDH1)[1]

In Vitro

WT IDH1 Inhibitor 2 (0.1~3 μM; 5 hours; A-498 cells) dose dependent decreases in reductive glutaminolysis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

501.55

Formula

C₂₈H₂₈FN₅O₃

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
WT IDH1 Inhibitor 2
Cat. No.:
HY-128888
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