2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. αC-Conotoxin PrXA

αC-Conotoxin PrXA  (Synonyms: αC-PrXA)

Cat. No.: HY-P5149 Purity: 98.44%
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αC-Conotoxin PrXA is a paralytic peptide neurotoxin and a competitive nAChR antagonist, with IC50s of 1.8 nM (α1β1εδ, adult) and 3.0 nM (α1β1γδ, fetal), respectively. αC-Conotoxin PrXA competes with α-bungarotoxin at the α/δ and α/γ subunit interfaces of the nAChR, shows high specificity against neuromuscular nAChR.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

αC-Conotoxin PrXA Chemical Structure

αC-Conotoxin PrXA Chemical Structure

Size Price Stock Quantity
1 mg USD 110 In-stock
5 mg USD 315 In-stock
10 mg USD 472 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

αC-Conotoxin PrXA Related Antibodies

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Description

αC-Conotoxin PrXA is a paralytic peptide neurotoxin and a competitive nAChR antagonist, with IC50s of 1.8 nM (α1β1εδ, adult) and 3.0 nM (α1β1γδ, fetal), respectively. αC-Conotoxin PrXA competes with α-bungarotoxin at the α/δ and α/γ subunit interfaces of the nAChR, shows high specificity against neuromuscular nAChR[1].

IC50 & Target

IC50: 1.8 nM (α1β1εδ, adult) and 3.0 nM (α1β1γδ, fetal)[1]
Molecular Weight

3541.06

Formula

C160H247N43O44S2
Appearance

Solid

Color

White to off-white

Sequence

Thr-Tyr-Gly-Ile-Tyr-Asp-Ala-Lys-Pro-{Hyp}-Phe-Ser-Cys-Ala-Gly-Leu-Arg-Gly-Gly-Cys-Val-Leu-Pro-{Hyp}-Asn-Leu-Arg-{Hyp}-Lys-Phe-Lys-Glu-NH2 (Disulfide bridge:Cys13-Cys20)
Sequence Shortening

TYGIYDAKP-{Hyp}-FSCAGLRGGCVLP-{Hyp}-NLR-{Hyp}-KFKE-NH2 (Disulfide bridge:Cys13-Cys20)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (28.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2824 mL 1.4120 mL 2.8240 mL
5 mM 0.0565 mL 0.2824 mL 0.5648 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.2824 mL 1.4120 mL 2.8240 mL 7.0600 mL
5 mM 0.0565 mL 0.2824 mL 0.5648 mL 1.4120 mL
10 mM 0.0282 mL 0.1412 mL 0.2824 mL 0.7060 mL
15 mM 0.0188 mL 0.0941 mL 0.1883 mL 0.4707 mL
20 mM 0.0141 mL 0.0706 mL 0.1412 mL 0.3530 mL
25 mM 0.0113 mL 0.0565 mL 0.1130 mL 0.2824 mL
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αC-Conotoxin PrXA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

αC-Conotoxin PrXAαC-PrXAnAChRNicotinic acetylcholine receptorsparalytic peptide neurotoxinInhibitorinhibitorinhibit

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