1,8-Dihydroxy-4,5-dinitroanthraquinone
Based on 1 Customer Validation
1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM.
For research use only. We do not sell to patients.
- Purity: 98.03%
- CAS No.: 81-55-0
- Formula: C14H6N2O8
- Molecular Weight:330.21
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LLC-MK2 | CC50 |
69.4 μM
Compound: ARDP0006
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Cytotoxicity against monkey LLC-MK2 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against monkey LLC-MK2 cells assessed as reduction in cell viability by MTT assay
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[PMID: 34298282] |
1,8-Dihydroxy-4,5-dinitroanthraquinone (25 μM; 12-48 h) inhibits extracellular and intracellular dengue virus growth in BHK-21 cells[1].
1,8-Dihydroxy-4,5-dinitroanthraquinone (50 μM-2 mM; 90 min) inhibits NS2B/3 cleavage, and significantly and dramatically acts function at 100 μM in BHK-21 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 81-55-0
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Appearance Solid
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Molecular Weight 330.21
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Formula C14H6N2O8
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Color Yellow to brown
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SMILES
O=C1C2=C(C(C3=C(C=CC(O)=C13)[N+]([O-])=O)=O)C([N+]([O-])=O)=CC=C2O
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Synonyms
ARDP0006; DHDNE
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 41.67 mg/mL (126.19 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0284 mL | 15.1419 mL | 30.2838 mL | 75.7094 mL |
| 5 mM | 0.6057 mL | 3.0284 mL | 6.0568 mL | 15.1419 mL | |
| 10 mM | 0.3028 mL | 1.5142 mL | 3.0284 mL | 7.5709 mL | |
| 15 mM | 0.2019 mL | 1.0095 mL | 2.0189 mL | 5.0473 mL | |
| 20 mM | 0.1514 mL | 0.7571 mL | 1.5142 mL | 3.7855 mL | |
| 25 mM | 0.1211 mL | 0.6057 mL | 1.2114 mL | 3.0284 mL | |
| 30 mM | 0.1009 mL | 0.5047 mL | 1.0095 mL | 2.5236 mL | |
| 40 mM | 0.0757 mL | 0.3785 mL | 0.7571 mL | 1.8927 mL | |
| 50 mM | 0.0606 mL | 0.3028 mL | 0.6057 mL | 1.5142 mL | |
| 60 mM | 0.0505 mL | 0.2524 mL | 0.5047 mL | 1.2618 mL | |
| 80 mM | 0.0379 mL | 0.1893 mL | 0.3785 mL | 0.9464 mL | |
| 100 mM | 0.0303 mL | 0.1514 mL | 0.3028 mL | 0.7571 mL |
1,8-Dihydroxy-4,5-dinitroanthraquinone Related Classifications
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