2. Anti-infection
  3. Dengue virus Flavivirus Virus Protease
  4. 1,8-Dihydroxy-4,5-dinitroanthraquinone

1,8-Dihydroxy-4,5-dinitroanthraquinone  (Synonyms: ARDP0006; DHDNE)

Cat. No.: HY-121138 Purity: 98.00%
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1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM.

For research use only. We do not sell to patients.

1,8-Dihydroxy-4,5-dinitroanthraquinone Chemical Structure

1,8-Dihydroxy-4,5-dinitroanthraquinone Chemical Structure

CAS No. : 81-55-0

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Based on 1 publication(s) in Google Scholar

1,8-Dihydroxy-4,5-dinitroanthraquinone Related Antibodies

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Description

1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM[1].

In Vitro

1,8-Dihydroxy-4,5-dinitroanthraquinone (25 μM; 12-48 h) inhibits extracellular and intracellular dengue virus growth in BHK-21 cells[1].
1,8-Dihydroxy-4,5-dinitroanthraquinone (50 μM-2 mM; 90 min) inhibits NS2B/3 cleavage, and significantly and dramatically acts function at 100 μM in BHK-21 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1,8-Dihydroxy-4,5-dinitroanthraquinone Related Antibodies
Molecular Weight

330.21

Formula

C14H6N2O8
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

O=C1C2=C(C(C3=C(C=CC(O)=C13)[N+]([O-])=O)=O)C([N+]([O-])=O)=CC=C2O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (126.19 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0284 mL 15.1419 mL 30.2838 mL
5 mM 0.6057 mL 3.0284 mL 6.0568 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0284 mL 15.1419 mL 30.2838 mL 75.7094 mL
5 mM 0.6057 mL 3.0284 mL 6.0568 mL 15.1419 mL
10 mM 0.3028 mL 1.5142 mL 3.0284 mL 7.5709 mL
15 mM 0.2019 mL 1.0095 mL 2.0189 mL 5.0473 mL
20 mM 0.1514 mL 0.7571 mL 1.5142 mL 3.7855 mL
25 mM 0.1211 mL 0.6057 mL 1.2114 mL 3.0284 mL
30 mM 0.1009 mL 0.5047 mL 1.0095 mL 2.5236 mL
40 mM 0.0757 mL 0.3785 mL 0.7571 mL 1.8927 mL
50 mM 0.0606 mL 0.3028 mL 0.6057 mL 1.5142 mL
60 mM 0.0505 mL 0.2524 mL 0.5047 mL 1.2618 mL
80 mM 0.0379 mL 0.1893 mL 0.3785 mL 0.9464 mL
100 mM 0.0303 mL 0.1514 mL 0.3028 mL 0.7571 mL
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1,8-Dihydroxy-4,5-dinitroanthraquinone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,8-Dihydroxy-4,5-dinitroanthraquinone81-55-0ARDP0006 DHDNEARDP 0006ARDP-0006Dengue virusFlavivirusVirus ProteaseDENVdengue viralInhibitorinhibitorinhibit

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