2. Anti-infection
  3. Virus Protease
  4. 1,8-Dihydroxy-4,5-dinitroanthraquinone

1,8-Dihydroxy-4,5-dinitroanthraquinone  (Synonyms: ARDP0006; DHDNE)

Cat. No.: HY-121138 Purity: 98.00%
COA Handling Instructions

1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM.

For research use only. We do not sell to patients.

1,8-Dihydroxy-4,5-dinitroanthraquinone Chemical Structure

1,8-Dihydroxy-4,5-dinitroanthraquinone Chemical Structure

CAS No. : 81-55-0

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Based on 1 publication(s) in Google Scholar

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Description

1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM[1].

In Vitro

1,8-Dihydroxy-4,5-dinitroanthraquinone (25 μM; 12-48 h) inhibits extracellular and intracellular dengue virus growth in BHK-21 cells[1].
1,8-Dihydroxy-4,5-dinitroanthraquinone (50 μM-2 mM; 90 min) inhibits NS2B/3 cleavage, and significantly and dramatically acts function at 100 μM in BHK-21 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

330.21

Appearance

Solid

Formula

C14H6N2O8
CAS No.
SMILES

O=C1C2=C(C(C3=C(C=CC(O)=C13)[N+]([O-])=O)=O)C([N+]([O-])=O)=CC=C2O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (126.19 mM; ultrasonic and warming and heat to 60°C)

氘代氯仿 : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0284 mL 15.1419 mL 30.2838 mL
5 mM 0.6057 mL 3.0284 mL 6.0568 mL
10 mM 0.3028 mL 1.5142 mL 3.0284 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

1,8-Dihydroxy-4,5-dinitroanthraquinone81-55-0ARDP0006 DHDNEARDP 0006ARDP-0006Virus Proteasedengue viralInhibitorinhibitorinhibit

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