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Kinesore 

Cat. No.: HY-112777
Handling Instructions

Kinesore is an inhibitor of the KLC2-SKIP Interaction.

For research use only. We do not sell to patients.

Kinesore Chemical Structure

Kinesore Chemical Structure

CAS No. : 363571-83-9

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Kinesore is an inhibitor of the KLC2-SKIP Interaction.

IC50 & Target

KLC2-SKIP[1].

In Vitro

Remarkably, in kinesore-treated cells, the microtubule network is entirely reorganized into a series of loops and bundles. In addition, the lysosomal compartment accumulates in a juxtanuclear position, where there are relatively few microtubules. At 50 μM kinesore, this phenotype is highly penetrant, with 95±2.4% (n=3, total of 200 cells) of cells exhibiting a reorganized nonradial microtubule network. In titration experiments, in cells treated for 1 h, this phenotype becomes apparent at a concentration of 25 μM kinesore, with relatively little effect at or below concentrations of 12.5 μM. The effect is reversible because a 2-h washout of kinesore from cells treated for 1 h led to the reestablishment of the radial microtubule array. This kinesore-induced reorganization of the microtubule network is observed in a panel of mammalian normal and cancer cell lines. In wild-type cells, 50 μM kinesore induces the remodeling of the microtubule network and the formation of extensive microtubule-rich projections. This phenotype is strongly suppressed in Kif5B knockout cells, confirming that microtubule remodeling induced by kinesore is dependent upon the presence of kinesin-1[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8651 mL 9.3254 mL 18.6508 mL
5 mM 0.3730 mL 1.8651 mL 3.7302 mL
10 mM 0.1865 mL 0.9325 mL 1.8651 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

To examine the effect of kinesore in cells, HeLa cells are treated with 50 μM kinesore or vehicle control (0.1% DMSO) for 1 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

536.17

Formula

C₂₀H₁₆Br₂N₄O₄

CAS No.

363571-83-9

SMILES

O=C(N/N=C/C1=C(C)N(C2=CC=CC([N+]([O-])=O)=C2)C(C)=C1)C3=CC(Br)=C(O)C(Br)=C3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Kinesore
Cat. No.:
HY-112777
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Kinesore

Cat. No.: HY-112777