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Cat. No.: HY-112777
Handling Instructions

Kinesore is an inhibitor of the KLC2-SKIP Interaction.

For research use only. We do not sell to patients.

Kinesore Chemical Structure

Kinesore Chemical Structure

CAS No. : 363571-83-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1239 In-stock
Estimated Time of Arrival: December 31
1 mg USD 350 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1050 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Kinesore is an inhibitor of the KLC2-SKIP Interaction.

IC50 & Target


In Vitro

Remarkably, in kinesore-treated cells, the microtubule network is entirely reorganized into a series of loops and bundles. In addition, the lysosomal compartment accumulates in a juxtanuclear position, where there are relatively few microtubules. At 50 μM kinesore, this phenotype is highly penetrant, with 95±2.4% (n=3, total of 200 cells) of cells exhibiting a reorganized nonradial microtubule network. In titration experiments, in cells treated for 1 h, this phenotype becomes apparent at a concentration of 25 μM kinesore, with relatively little effect at or below concentrations of 12.5 μM. The effect is reversible because a 2-h washout of kinesore from cells treated for 1 h led to the reestablishment of the radial microtubule array. This kinesore-induced reorganization of the microtubule network is observed in a panel of mammalian normal and cancer cell lines. In wild-type cells, 50 μM kinesore induces the remodeling of the microtubule network and the formation of extensive microtubule-rich projections. This phenotype is strongly suppressed in Kif5B knockout cells, confirming that microtubule remodeling induced by kinesore is dependent upon the presence of kinesin-1[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8651 mL 9.3254 mL 18.6508 mL
5 mM 0.3730 mL 1.8651 mL 3.7302 mL
10 mM 0.1865 mL 0.9325 mL 1.8651 mL
*Please refer to the solubility information to select the appropriate solvent.
Cell Assay

To examine the effect of kinesore in cells, HeLa cells are treated with 50 μM kinesore or vehicle control (0.1% DMSO) for 1 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight









Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

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Cat. No.: HY-112777