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Cat. No.: HY-112777 Purity: >98.0%
Handling Instructions

Kinesore is an inhibitor of the KLC2-SKIP Interaction.

For research use only. We do not sell to patients.

Kinesore Chemical Structure

Kinesore Chemical Structure

CAS No. : 363571-83-9

Size Price Stock Quantity
1 mg USD 185 In-stock
Estimated Time of Arrival: December 31
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Kinesore is an inhibitor of the KLC2-SKIP Interaction.

IC50 & Target


In Vitro

Remarkably, in kinesore-treated cells, the microtubule network is entirely reorganized into a series of loops and bundles. In addition, the lysosomal compartment accumulates in a juxtanuclear position, where there are relatively few microtubules. At 50 μM kinesore, this phenotype is highly penetrant, with 95±2.4% (n=3, total of 200 cells) of cells exhibiting a reorganized nonradial microtubule network. In titration experiments, in cells treated for 1 h, this phenotype becomes apparent at a concentration of 25 μM kinesore, with relatively little effect at or below concentrations of 12.5 μM. The effect is reversible because a 2-h washout of kinesore from cells treated for 1 h led to the reestablishment of the radial microtubule array. This kinesore-induced reorganization of the microtubule network is observed in a panel of mammalian normal and cancer cell lines. In wild-type cells, 50 μM kinesore induces the remodeling of the microtubule network and the formation of extensive microtubule-rich projections. This phenotype is strongly suppressed in Kif5B knockout cells, confirming that microtubule remodeling induced by kinesore is dependent upon the presence of kinesin-1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight









Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (233.14 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8651 mL 9.3254 mL 18.6508 mL
5 mM 0.3730 mL 1.8651 mL 3.7302 mL
10 mM 0.1865 mL 0.9325 mL 1.8651 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (3.88 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
Cell Assay

To examine the effect of kinesore in cells, HeLa cells are treated with 50 μM kinesore or vehicle control (0.1% DMSO) for 1 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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