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NE 10790 (Synonyms: 3-PEHPC)

Cat. No.: HY-16011
Handling Instructions

NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.

For research use only. We do not sell to patients.

NE 10790 Chemical Structure

NE 10790 Chemical Structure

CAS No. : 152831-36-2

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.

IC50 & Target

FPP synthase[1].

In Vitro

NE 10790 inhibits incorporation of [14C]mevalonic acid into Rab6, but not into H-Ras or Rap1, proteins that are modified by FTase and GGTase I, respectively. NE 10790 reduces viability in J774 cells. NE 10790 prevents prenylation of 22-26-kDa proteins that are not modified by FTase or GGTase I[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0463 mL 20.2314 mL 40.4629 mL
5 mM 0.8093 mL 4.0463 mL 8.0926 mL
10 mM 0.4046 mL 2.0231 mL 4.0463 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

247.14

Formula

C₈H₁₀NO₆P

CAS No.

152831-36-2

SMILES

OC(C(O)=O)(P(O)(O)=O)CC1=CC=CN=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
NE 10790
Cat. No.:
HY-16011
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NE 10790

Cat. No.: HY-16011