NE 10790
Based on 3 publication(s) in Google Scholar
NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 152831-36-2
- Formula: C8H10NO6P
- Molecular Weight:247.14
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) NE 10790
More
Biological Activity
FPP synthase[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| J774 | IC50 |
2800 μM
Compound: (+/-)-1
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Cytotoxicity against mouse J774 cells assessed as cell viability after 48 hrs by alamar blue assay
Cytotoxicity against mouse J774 cells assessed as cell viability after 48 hrs by alamar blue assay
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[PMID: 20394422] |
| Osteoclast | IC50 |
970 μM
Compound: (+/-)-1
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Antiresorptive activity in rabbit osteoclasts assessed as number of actin rings after 48 hrs using TRITC-phelloidin stain relative to control
Antiresorptive activity in rabbit osteoclasts assessed as number of actin rings after 48 hrs using TRITC-phelloidin stain relative to control
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[PMID: 20394422] |
NE 10790 inhibits incorporation of [14C]mevalonic acid into Rab6, but not into H-Ras or Rap1, proteins that are modified by FTase and GGTase I, respectively. NE 10790 reduces viability in J774 cells. NE 10790 prevents prenylation of 22-26-kDa proteins that are not modified by FTase or GGTase I[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 152831-36-2
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Appearance Solid
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Molecular Weight 247.14
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Formula C8H10NO6P
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Color White to off-white
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SMILES
OC(C(O)=O)(P(O)(O)=O)CC1=CC=CN=C1
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Synonyms
3-PEHPC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (3)
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Journal Impact Factor
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Most Recent
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Autophagy
Bisphosphonate zoledronic acid blocks secretory autophagy and inhibits bone resorptive functions in osteoclasts. [Abstract]2026 Jun 28:1-13. PMID: 42316434 -
Int J Mol Sci
Palmitoylation Code and Endosomal Sorting Regulate ABHD17A Plasma Membrane Targeting and Activity. [Abstract]2025 Oct 20;26(20):10190. PMID: 41155484 -
Solvent & Solubility
1 M NaOH : ≥ 100 mg/mL (404.63 mM)
0.1 M NaOH : 10 mg/mL (40.46 mM; Need ultrasonic)
H2O : 1.67 mg/mL (6.76 mM; ultrasonic and warming and heat to 60°C)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 2 mg/mL (8.09 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / 0.1 M NaOH / 1 M NaOH | 1 mM | 4.0463 mL | 20.2314 mL | 40.4629 mL | 101.1572 mL |
| 5 mM | 0.8093 mL | 4.0463 mL | 8.0926 mL | 20.2314 mL | |
| 0.1 M NaOH / 1 M NaOH | 10 mM | 0.4046 mL | 2.0231 mL | 4.0463 mL | 10.1157 mL |
| 15 mM | 0.2698 mL | 1.3488 mL | 2.6975 mL | 6.7438 mL | |
| 20 mM | 0.2023 mL | 1.0116 mL | 2.0231 mL | 5.0579 mL | |
| 25 mM | 0.1619 mL | 0.8093 mL | 1.6185 mL | 4.0463 mL | |
| 30 mM | 0.1349 mL | 0.6744 mL | 1.3488 mL | 3.3719 mL | |
| 40 mM | 0.1012 mL | 0.5058 mL | 1.0116 mL | 2.5289 mL | |
| 1 M NaOH | 50 mM | 0.0809 mL | 0.4046 mL | 0.8093 mL | 2.0231 mL |
| 60 mM | 0.0674 mL | 0.3372 mL | 0.6744 mL | 1.6860 mL | |
| 80 mM | 0.0506 mL | 0.2529 mL | 0.5058 mL | 1.2645 mL | |
| 100 mM | 0.0405 mL | 0.2023 mL | 0.4046 mL | 1.0116 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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