2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-102037R
    SSTR5 antagonist 1 (Standard) 1628741-91-2 98%
    SSTR5 antagonist 1 (Standard) is the analytical standard of SSTR5 antagonist 1 (HY-102037). This product is intended for research and analytical applications. SSTR5 antagonist 1 (compound 25a) is a selective and orally available somatostatin receptor subtype 5 (SSTR5) antagonist with IC50s of 9.6 and 57 nM for hSSTR5 and mSSTR5, respectively.
    SSTR5 antagonist 1 (Standard)
  • HY-102093R
    ZD 7155hydrochloride (Standard) 146709-78-6 98%
    ZD 7155(hydrochloride) (Standard) is the analytical standard of ZD 7155(hydrochloride). This product is intended for research and analytical applications. ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.
    ZD 7155hydrochloride (Standard)
  • HY-10259AR
    PD 123319 ditrifluoroacetate (Standard) 136676-91-0 98%
    PD 123319 ditrifluoroacetate (Standard) is the analytical standard of PD 123319 ditrifluoroacetate (HY-10259A). This product is intended for research and analytical applications. PD 123319 ditrifluoroacetate is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
    PD 123319 ditrifluoroacetate (Standard)
  • HY-103005R
    Ramelteon metabolite M-II (Standard) 896736-21-3
    Amlodipine (maleate) (Standard) is the analytical standard of Amlodipine (maleate). This product is intended for research and analytical applications. Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.
    Ramelteon metabolite M-II (Standard)
  • HY-103007R
    TC-G-1008 (Standard) 1621175-65-2 98%
    TC-G-1008 (Standard) is the analytical standard of TC-G-1008 (HY-103007). This product is intended for research and analytical applications. TC-G-1008 (GPR39-C3) is a potent and orally available GPR39 agonist with EC50 values of 0.4 and 0.8 nM for rat and human receptors respectively.
    TC-G-1008 (Standard)
  • HY-103088R
    Palupiprant (Standard) 1369489-71-3 98%
    Palupiprant (Standard) is the analytical standard of Palupiprant (HY-103088). This product is intended for research and analytical applications. Palupiprant (E7046) is an orally bioavailable and specific EP4 antagonist, with IC50 of 13.5 nM and Ki of 23.14 nM. Palupiprant exhibits anti-tumor activities.
    Palupiprant (Standard)
  • HY-103204R
    RS100329 hydrochloride (Standard) 1215654-26-4
    RS100329 hydrochloride (Standard) is the analytical standard of RS100329 hydrochloride (HY-103204). This product is intended for research and analytical applications. RS100329 hydrochloride is a potent and selective α1A-adrenoceptor antagonist with pKi values of 9.6, 7.9 and 7.5 for α1A, α1D, and α1B, respectively. RS100329 hydrochloride inhibits reflex urethral contractions. RS100329 hydrochloride can be used in research of benign prostatic hyperplasia.
    RS100329 hydrochloride (Standard)
  • HY-103213R
    JP1302 dihydrochloride (Standard) 1259314-65-2 98%
    JP1302 dihydrochloride (Standard) is the analytical standard of JP1302 dihydrochloride. This product is intended for research and analytical applications. JP1302 dihydrochloride is a potent, selective, high affinity antagonist of the α2C-adrenoceptor, with a Kb of 16 nM and a Ki of 28 nM for the human α2C-receptor. JP1302 dihydrochloride shows antidepressant and antipsychotic-like effects. JP1302 dihydrochloride can be used for neuropsychiatric disorders and renal dysfunction research.
    JP1302 dihydrochloride (Standard)
  • HY-103214R
    Bucindolol (Standard) 71119-11-4 98%
    Bucindolol (Standard) is the analytical standard of Bucindolol. This product is intended for research and analytical applications. Bucindolol is a β1-adrenergic receptor blocker, with intrinsic sympathomimetic activity, used in the research of heart failure.
    Bucindolol (Standard)
  • HY-103261R
    SCH28080 (Standard) 76081-98-6 98%
    SCH28080 (Standard) is the analytical standard of SCH28080. This product is intended for research and analytical applications. SCH28080 is a reversible, K+-competitive inhibitor of the gastric H,K-ATPase, with a Ki of 0.12 μM. SCH28080 is an effective inhibitor of acid secretion in vivo and with anti-gastric ulcer activity.
    SCH28080 (Standard)
  • HY-103302R
    SUN B8155 (Standard) 345893-91-6
    SUN B8155 (Standard) is the analytical standard of SUN B8155 (HY-103302). This product is intended for research and analytical applications. SUN B8155, a non-peptide agonist of calcitonin (CT) receptor, selectively mimics the biological actions of calcitonin. Calcitonin, a 32-amino acid peptide hormone secreted mainly from the thyroid gland, plays an important role in maintaining bone homeostasis.
    SUN B8155 (Standard)
  • HY-103354R
    Proglumide sodium (Standard) 99247-33-3 98%
    Proglumide (sodium) (Standard) is the analytical standard of Proglumide (sodium). This product is intended for research and analytical applications. Proglumide sodium is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide sodium selective blocks CCK’s effects in the central nervous system (CNS). Proglumide sodium has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide sodium also has antiepileptic and antioxidant activities.
    Proglumide sodium (Standard)
  • HY-103377R
    Antalarmin hydrochloride (Standard) 220953-69-5 98%
    Antalarmin (hydrochloride) (Standard) is the analytical standard of Antalarmin (hydrochloride). This product is intended for research and analytical applications. Antalarmin (hydrochloride) is an oral active non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist with a Ki of 1 nM. Antalarmin hydrochloride suppresses CRH-induced ACTH secretion and blocks CRH and novelty induced anxiety-like behavior in animal models. Antalarmin hydrochloride produces anti-inflammatory effects in arthritis models, and suppresses stress-induced gastric ulceration related to irritable bowel syndrome.
    Antalarmin hydrochloride (Standard)
  • HY-103450R
    G36 (Standard) 1392487-51-2
    G36 (Standard) is the analytical standard of G36 (HY-103450). This product is intended for research and analytical applications. G-36 is a cell-permeable nonsteroidal antagonist of the G protein-coupled estrogen receptor (GPER/GPR30), which selectively inhibits estrogen-mediated PI3K activation through GPER, rather than Erα. G-36 also inhibits estrogen-mediated calcium mobilization (IC50=112 nM). G-36 is promising for research in the field of cancer.
    G36 (Standard)
  • HY-103454R
    MPP dihydrochloride (Standard) 911295-24-4
    MPP dihydrochloride (Standard) is the analytical standard of MPP dihydrochloride (HY-103454). This product is intended for research and analytical applications. MPP dihydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP dihydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP dihydrochloride reverses the positive effects of beta-estradiol. MPP dihydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo.
    MPP dihydrochloride (Standard)
  • HY-103576R
    LGD-3303 (Standard) 917891-35-1
    LGD-3303 (Standard) is the analytical standard of LGD-3303 (HY-103576). This product is intended for research and analytical applications. LGD-3303 is a selective androgen receptor modulator (SARM).
    LGD-3303 (Standard)
  • HY-103662R
    GW-870086 (Standard) 827319-43-7
    GW-870086 (Standard) is the analytical standard of GW-870086 (HY-103662). This product is intended for research and analytical applications. GW-870086 is a potent anti-inflammatory agent, acting as a glucocorticoid receptor agonist, with a pIC50 of 10.1 in A549 cells expressing NF-κB.
    GW-870086 (Standard)
  • HY-104003R
    S 38093 (Standard) 862896-30-8
    S 38093 (Standard) is the analytical standard of S 38093 (HY-104003). This product is intended for research and analytical applications. S 38093 is a brain-penetrant, orally active antagonist of H3 receptor, with Kis of 8.8, 1.44 and 1.2 μM for rat, mouse and human H3 receptors, respectively.
    S 38093 (Standard)
  • HY-104038R
    Pariceract (Standard) 1919820-28-2 98%
    Pariceract (Standard) is the analytical standard of Pariceract (HY-104038). This product is intended for research and analytical applications. Pariceract (LTI-291) is an activator of glucocerebrosidase (Gcase), with activation rates of more than 60% (1 μM) and between 10%-20% (0.1 μM). Pariceract can be used for Parkinson's disease and endometriosis research.
    Pariceract (Standard)
  • HY-105124R
    Bufuralol (Standard) 54340-62-4 98%
    Bufuralol (Standard) is the analytical standard of Bufuralol (HY-105124). This product is intended for research and analytical applications. Bufuralol (Ro 3-4787) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate.
    Bufuralol (Standard)
Cat. No. Product Name / Synonyms Application Reactivity