1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor

Sultopride (Synonyms: LIN-1418)

Cat. No.: HY-42849
Handling Instructions

Sultopride is a selective antagonist of dopamine D2 receptor.

For research use only. We do not sell to patients.

Sultopride Chemical Structure

Sultopride Chemical Structure

CAS No. : 53583-79-2

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5 mg USD 120 Get quote
10 mg USD 210 Get quote
25 mg USD 420 Get quote
50 mg USD 700 Get quote

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Sultopride is a selective antagonist of dopamine D2 receptor.

IC50 & Target

Dopamine D2 receptor[1]

In Vivo

Sultopride is a selective antagonist of dopamine D2 receptor. DOPAC and HVA levels in the striatum, the nucleus accumbens and the medial prefrontal cortex are higher in the rats treated with Sultopride and sulpiride than those of the controls. In the striatum, DOPAC and HVA levels are higher in the Sultopride-treated rats than the sulpiride-treated rats (p<0.05). In the nucleus accumbens, DOPAC levels are higher in the Sultopride-treated rats than sulpiride treated rats (p<0.05). In the Sultopride-treated rats, DOPAC and HVA levels are higher in the striatum or in the nucleus accumbens than in the medial prefrontal cortex (p<0.05)[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8212 mL 14.1060 mL 28.2119 mL
5 mM 0.5642 mL 2.8212 mL 5.6424 mL
10 mM 0.2821 mL 1.4106 mL 2.8212 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Thirty-six male Sprague-Dawley rats weighing 180 to 220 g are used in this study. The rats are divided into three groups of 6 each. One group is intraperitoneally injected with Sultopride (100 mg/kg body weight), the second group with sulphide (100 mg/kg body weight), and the third group with normal saline. One hundred minutes after the initial treatments, apomorphine (0.1 mg/kg body weight, dissolved in saline ad libitum) is administered subcutaneously to the three groups, and 20 minutes later the rats are sacrificed. The third group serves as controls[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

354.46

Formula

C₁₇H₂₆N₂O₄S

CAS No.

53583-79-2

SMILES

O=C(NCC1N(CC)CCC1)C2=CC(S(=O)(CC)=O)=CC=C2OC

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Sultopride
Cat. No.:
HY-42849
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Sultopride

Cat. No.: HY-42849