1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Sultopride

Sultopride (Synonyms: LIN-1418)

Cat. No.: HY-42849
Handling Instructions

Sultopride (LIN-1418) is a selective antagonist of dopamine D2 receptor.

For research use only. We do not sell to patients.

Sultopride Chemical Structure

Sultopride Chemical Structure

CAS No. : 53583-79-2

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Sultopride (LIN-1418) is a selective antagonist of dopamine D2 receptor.

IC50 & Target

Dopamine D2 receptor[1]

In Vivo

Sultopride (LIN-1418) is a selective antagonist of dopamine D2 receptor. DOPAC and HVA levels in the striatum, the nucleus accumbens and the medial prefrontal cortex are higher in the rats treated with Sultopride and sulpiride than those of the controls. In the striatum, DOPAC and HVA levels are higher in the Sultopride-treated rats than the sulpiride-treated rats (p<0.05). In the nucleus accumbens, DOPAC levels are higher in the Sultopride-treated rats than sulpiride treated rats (p<0.05). In the Sultopride-treated rats, DOPAC and HVA levels are higher in the striatum or in the nucleus accumbens than in the medial prefrontal cortex (p<0.05)[1].

Molecular Weight









Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

Animal Administration

Thirty-six male Sprague-Dawley rats weighing 180 to 220 g are used in this study. The rats are divided into three groups of 6 each. One group is intraperitoneally injected with Sultopride (100 mg/kg body weight), the second group with sulphide (100 mg/kg body weight), and the third group with normal saline. One hundred minutes after the initial treatments, apomorphine (0.1 mg/kg body weight, dissolved in saline ad libitum) is administered subcutaneously to the three groups, and 20 minutes later the rats are sacrificed. The third group serves as controls[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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SultoprideLIN-1418LIN1418LIN 1418Dopamine ReceptordopamineD2receptorDOPACHVAlevelsstriatumInhibitorinhibitorinhibit

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