1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Sultopride hydrochloride

Sultopride hydrochloride (Synonyms: LIN-1418 hydrochloride)

Cat. No.: HY-42849A Purity: 99.96%
Handling Instructions

Sultopride hydrochloride is a selective antagonist of dopamine D2 receptor.

For research use only. We do not sell to patients.

Sultopride hydrochloride Chemical Structure

Sultopride hydrochloride Chemical Structure

CAS No. : 23694-17-9

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 210 In-stock
Estimated Time of Arrival: December 31
25 mg USD 420 In-stock
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50 mg USD 700 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Sultopride hydrochloride:

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Description

Sultopride hydrochloride is a selective antagonist of dopamine D2 receptor.

IC50 & Target

Dopamine D2 receptor[1]

In Vivo

Sultopride hydrochloride is a selective antagonist of dopamine D2 receptor. DOPAC and HVA levels in the striatum, the nucleus accumbens and the medial prefrontal cortex are higher in the rats treated with Sultopride hydrochloride and sulpiride than those of the controls. In the striatum, DOPAC and HVA levels are higher in the Sultopride hydrochloride-treated rats than the sulpiride-treated rats (p<0.05). In the nucleus accumbens, DOPAC levels are higher in the Sultopride hydrochloride-treated rats than sulpiride treated rats (p<0.05). In the Sultopride hydrochloride-treated rats, DOPAC and HVA levels are higher in the striatum or in the nucleus accumbens than in the medial prefrontal cortex (p<0.05)[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (127.90 mM; Need ultrasonic)

DMSO : 50 mg/mL (127.90 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5580 mL 12.7900 mL 25.5800 mL
5 mM 0.5116 mL 2.5580 mL 5.1160 mL
10 mM 0.2558 mL 1.2790 mL 2.5580 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Thirty-six male Sprague-Dawley rats weighing 180 to 220 g are used in this study. The rats are divided into three groups of 6 each. One group is intraperitoneally injected with Sultopride hydrochloride (100 mg/kg body weight), the second group with sulphide (100 mg/kg body weight), and the third group with normal saline. One hundred minutes after the initial treatments, apomorphine (0.1 mg/kg body weight, dissolved in saline ad libitum) is administered subcutaneously to the three groups, and 20 minutes later the rats are sacrificed. The third group serves as controls[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

390.93

Formula

C₁₇H₂₇ClN₂O₄S

CAS No.

23694-17-9

SMILES

O=C(NCC1N(CC)CCC1)C2=CC(S(=O)(CC)=O)=CC=C2OC.Cl

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Sultopride hydrochloride
Cat. No.:
HY-42849A
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Sultopride hydrochloride

Cat. No.: HY-42849A