2. Signaling Pathways
  3. GPCR/G Protein
  4. ICMT

ICMT

Isoprenylcysteine carboxyl methyltransferase

ICMT (Isoprenylcysteine carboxyl methyltransferase) is an enzyme involved in complex post-translational modification processes and plays a key role in the post-translational regulation of prenylated proteins. ICMT primarily catalyzes the methylation of post-translationally isoprene-methylated C-terminal cysteine residues and targets these proteins to the cell membrane. This modification provides the substrate protein with a hydrophobic uncharged C terminus, thereby enhancing interaction with biological membranes and/or altering the ability to interact with protein partners. ICMT-catalyzed protein prenylation may play a role in cancer. Examples include ICMT-modified RHO GTPases or Ras family members. When the ICMT gene is knocked out, it can inhibit KRAS-induced embryonic fibroblast transformation and inhibit RAS-driven tumorigenesis; or ICMT inhibition can hinder RHO GTPase-related cancer cell invasiveness and metastasis[1][2].

ICMT Related Products (66):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-157092B
    (R)-ICMT-IN-3
    		Inhibitor
    (R)-ICMT-IN-3 (compound ent 2-27) is an inhibitor of ICMT (IC50=0.01 μM).
    (R)-ICMT-IN-3
  • HY-157104
    ICMT-IN-36
    		Inhibitor
    ICMT-IN-36 (compound 40) is an inhibitor of ICMT (IC50=0.181 μM).
    ICMT-IN-36
  • HY-149706
    ICMT-IN-12
    		Inhibitor
    ICMT-IN-12 (compound 78) is an inhibitor of ICMT (IC50=0.42 μM).
    ICMT-IN-12
  • HY-157096
    ICMT-IN-8
    		Inhibitor
    ICMT-IN-8 (compound 30) is an inhibitor of ICMT (IC50=0.652 μM).
    ICMT-IN-8
  • HY-149707
    ICMT-IN-21
    		Inhibitor
    ICMT-IN-21 (compound 6ag) is an ICMT inhibitor (IC50=8.8 μM), a sulfonamide-modified farnesyl cysteine (SMFC). The farnesyl and carboxylic acid motifs of ICMT-IN-21 are important structures for inhibiting ICMT.
    ICMT-IN-21
  • HY-155425
    ICMT-IN-17
    		Inhibitor
    ICMT-IN-17 (compound 52) is an inhibitor of ICMT (IC50=0.38 μM).
    ICMT-IN-17
  • HY-157102
    ICMT-IN-26
    		Inhibitor
    ICMT-IN-26 (compound 38) is an inhibitor of ICMT (IC50=0.36 μM).
    ICMT-IN-26
  • HY-157098
    ICMT-IN-16
    		Inhibitor
    ICMT-IN-16 (compound 33) is an inhibitor of ICMT (IC50=0.131 μM).
    ICMT-IN-16
  • HY-157109
    ICMT-IN-41
    		Inhibitor
    ICMT-IN-41 (compound 20) is an inhibitor of ICMT (IC50=0.069 μM).
    ICMT-IN-41
  • HY-155434
    ICMT-IN-31
    		Inhibitor
    ICMT-IN-31 (compound 68) is an inhibitor of ICMT (IC50=0.0038 μM).
    ICMT-IN-31
  • HY-149730
    ICMT-IN-54
    		Inhibitor
    ICMT-IN-54 (compound 7c) is an adamantyl analogue and an ICMT inhibitor (IC50=12.4 μM), which can inhibit ICMT Methylation. ICMT-in-54 inhibits BFC (N-biotinyl-(6-aminohexanoic)-S-farnesyl-L-cysteine) methylation in saccharomyces cerevisiae expressing ICMT, which is an indirect effect of inhibiting ICMT methylation.
    ICMT-IN-54
  • HY-157099
    ICMT-IN-18
    		Inhibitor
    ICMT-IN-18 (compound 35) is an inhibitor of ICMT (IC50=0.066 μM).
    ICMT-IN-18
  • HY-157108
    ICMT-IN-40
    		Inhibitor
    ICMT-IN-40 (compound 19) is an inhibitor of ICMT (IC50=0.031 μM).
    ICMT-IN-40
  • HY-155421
    ICMT-IN-11
    		Inhibitor
    ICMT-IN-11 (compound 48) is an inhibitor of ICMT (IC50=0.031 μM).
    ICMT-IN-11
  • HY-155432
    ICMT-IN-29
    		Inhibitor
    ICMT-IN-29 (compound 66) is an inhibitor of ICMT (IC50=0.019 μM).
    ICMT-IN-29
  • HY-157106
    ICMT-IN-38
    		Inhibitor
    ICMT-IN-38 (compound 42) is an inhibitor of ICMT (IC50=0.049 μM).
    ICMT-IN-38
  • HY-157111
    ICMT-IN-43
    		Inhibitor
    ICMT-IN-43 (compound 22) is an inhibitor of ICMT (IC50=0.04 μM).
    ICMT-IN-43
  • HY-157107
    ICMT-IN-39
    		Inhibitor
    ICMT-IN-39 (compound 18) is an inhibitor of ICMT (IC50=0.031 μM).
    ICMT-IN-39
  • HY-155435
    ICMT-IN-32
    		Inhibitor
    ICMT-IN-32 (compound 70) is an inhibitor of ICMT (IC50=0.777 μM).
    ICMT-IN-32
  • HY-157100
    ICMT-IN-23
    		Inhibitor
    ICMT-IN-23 (compound 36) is an inhibitor of ICMT (IC50=0.123 μM).
    ICMT-IN-23