2. GPCR/G Protein
  3. ICMT
  4. ICMT-IN-54

ICMT-IN-54 (compound 7c) is an adamantyl analogue and an ICMT inhibitor (IC50=12.4 μM), which can inhibit ICMT Methylation. ICMT-in-54 inhibits BFC (N-biotinyl-(6-aminohexanoic)-S-farnesyl-L-cysteine) methylation in saccharomyces cerevisiae expressing ICMT, which is an indirect effect of inhibiting ICMT methylation.

For research use only. We do not sell to patients.

ICMT-IN-54 Chemical Structure

ICMT-IN-54 Chemical Structure

CAS No. : 908856-14-4

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ICMT-IN-54 Related Antibodies

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Description

ICMT-IN-54 (compound 7c) is an adamantyl analogue and an ICMT inhibitor (IC50=12.4 μM), which can inhibit ICMT Methylation. ICMT-in-54 inhibits BFC (N-biotinyl-(6-aminohexanoic)-S-farnesyl-L-cysteine) methylation in saccharomyces cerevisiae expressing ICMT, which is an indirect effect of inhibiting ICMT methylation[1].

IC50 & Target

IC50: 12.4 μM (human ICMT)[1]
Molecular Weight

487.74

Formula

C29H45NO3S
CAS No.
SMILES

C/C(C)=C/CC/C(C)=C/CC/C(C)=C/CSC[C@@H](C(O)=O)NC(C12CC3CC(CC(C3)C2)C1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ICMT-IN-54 Related Classifications

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Keywords:

ICMT-IN-54908856-14-4ICMTIsoprenylcysteine carboxyl methyltransferaseMelanomacancer cell metastasiscell proliferationRAS membrane localizationmislocalizationisoprenylcysteine carboxyl methyltransferaseInhibitorinhibitorinhibit

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