2. Signaling Pathways
  3. GPCR/G Protein
  4. ICMT
  5. ICMT Inhibitor

ICMT Inhibitor

ICMT Inhibitors (66):

Cat. No. Product Name Effect Purity
  • HY-156500
    ICMT-IN-1
    		Inhibitor 98.43%
    ICMT-IN-1 (compound 75) is an inhibitor of ICMT (IC50=0.0013 μM). ICMT-IN-1 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras.
  • HY-118563
    Farnesylthioacetic acid
    		Inhibitor
    Farnesylthioacetic acid is a competitive, non-substrate inhibitor of Prenylcysteine α-carboxyl methyltransferase. It acts as a non-substrate competitive inhibitor of Arabidopsis thaliana Prenylcysteine α-carboxyl methyltransferase and blocks methyltransferase activity. Farnesylthioacetic acid does not inhibit protein farnesyltransferase activity in Arabidopsis. It induces Apoptosis. Farnesylthioacetic acid regulates the subcellular localization of Ras protein, reducing the proportion of cytoplasmic Ras protein without disrupting membrane binding. It enhances ABA-induced seed dormancy, delays seed germination, and promotes maximum stomatal closure at lower exogenous ABA concentrations. Farnesylthioacetic acid can be used in studies related to promyelocytic leukemia.
  • HY-149708
    UCM-13207
    		Inhibitor 99.61%
    UCM-13207 is a selective isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor with a human IC50 of 1.4 μM and human Ka of 7.2 μM. UCM-13207 modulates progerin localization, stability, and levels, reduces DNA damage, increases cellular viability, and decreases tissue senescence. UCM-13207 can be used for the research of Hutchinson−Gilford progeria syndrome.
  • HY-155433
    ICMT-IN-30
    		Inhibitor
    ICMT-IN-30 (compound 67) is an inhibitor of ICMT (IC50=0.27 μM).
  • HY-157092A
    (S)-ICMT-IN-3
    		Inhibitor
    (S)-ICMT-IN-3 (compound ent 1-27) is an inhibitor of ICMT (IC50=0.23 μM).
  • HY-155431
    ICMT-IN-28
    		Inhibitor
    ICMT-IN-28 (compound 65) is an inhibitor of ICMT (IC50=0.008 μM).
  • HY-157120
    ICMT-IN-52
    		Inhibitor
    ICMT-IN-52 (compound 44) is an inhibitor of ICMT (IC50=0.052 μM).
  • HY-155419
    ICMT-IN-5
    		Inhibitor
    ICMT-IN-5 (compound 46) is an inhibitor of ICMT (IC50=0.3 μM).
  • HY-157103
    ICMT-IN-34
    		Inhibitor
    ICMT-IN-34 (compound 39) is an inhibitor of ICMT (IC50=0.17 μM).
  • HY-157119
    ICMT-IN-51
    		Inhibitor
    ICMT-IN-51 (compound 43) is an inhibitor of ICMT (IC50=0.55 μM).
  • HY-149705
    ICMT-IN-7
    		Inhibitor
    ICMT-IN-7 (compound 74) is an inhibitor of ICMT (IC50=0.015 μM). ICMT-IN-7 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras.
  • HY-157095
    ICMT-IN-6
    		Inhibitor
    ICMT-IN-6 (compound 29) is an inhibitor of ICMT (IC50=0.09 μM).
  • HY-157118
    ICMT-IN-50
    		Inhibitor
    ICMT-IN-50 (compound 3) is an inhibitor of ICMT (IC50=0.31 μM).
  • HY-155429
    ICMT-IN-24
    		Inhibitor
    ICMT-IN-24 (compound 63) is an inhibitor of ICMT (IC50=0.19 μM).
  • HY-155424
    ICMT-IN-15
    		Inhibitor
    ICMT-IN-15 (compound 51) is an inhibitor of ICMT (IC50=0.032 μM).
  • HY-155422
    ICMT-IN-13
    		Inhibitor
    ICMT-IN-13 (compound 49) is an inhibitor of ICMT (IC50=0.47 μM).
  • HY-157114
    ICMT-IN-46
    		Inhibitor
    ICMT-IN-46 (compound 25) is an inhibitor of ICMT (IC50=0.556 μM).
  • HY-157105
    ICMT-IN-37
    		Inhibitor
    ICMT-IN-37 (compound 41) is an inhibitor of ICMT (IC50=0.308 μM).
  • HY-155430
    ICMT-IN-27
    		Inhibitor
    ICMT-IN-27 (compound 64) is an inhibitor of ICMT (IC50=0.1 μM).
  • HY-155427
    ICMT-IN-20
    		Inhibitor
    ICMT-IN-20 (compound 54) is an inhibitor of ICMT (IC50=0.682 μM).