1621536-10-4
1621536-10-4
Chemical Structure
UCM-13207
- CAS No.: 1621536-10-4
- Formula:C24H32N2O2
- Molecular Weight:380.52
InChIKey: BLQZCBCZOHGCHD-UHFFFAOYSA-N
SMILES: O=C(CCN(CCCCCCCC)C(C1=CC=CC=C1)=O)NC2=CC=CC=C2
Biological Activity: UCM-13207 is a selective isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor with a human IC50 of 1.4 μM and human Ka of 7.2 μM. UCM-13207 modulates progerin localization, stability, and levels, reduces DNA damage, increases cellular viability, and decreases tissue senescence. UCM-13207 can be used for the research of Hutchinson−Gilford progeria syndrome[1].
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UCM-13207 | 99.61% | UCM-13207 is a selective isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor with a human IC50 of 1.4 μM and human Ka of 7.2 μM. UCM-13207 modulates progerin localization, stability, and levels, reduces DNA damage, increases cellular viability, and decreases tissue senescence. UCM-13207 can be used for the research of Hutchinson−Gilford progeria syndrome. | ||||||||||||||||||||
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References
Keywords
