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Cat. No.: HY-101299

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(+)-Dihydrexidine hydrochloride

(Synonyms: (+)-DAR-0100 hydrochloride)

(+)-Dihydrexidine hydrochloride ((+)-DAR-0100 hydrochloride) is a dopamine D1 receptor agonist with an EC₅₀ of 72± 21 nM.

For research use only. We do not sell to patients.

CAS No.: 158704-02-0
Formula: C₁₇H₁₈ClNO₂
Molecular Weight:303.78

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (288 KB)

(+)-Dihydrexidine hydrochloride Chemical Structure

CAS No.: 158704-02-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Protocol
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

(+)-Dihydrexidine hydrochloride ((+)-DAR-0100 hydrochloride) is a dopamine D1 receptor agonist with an EC₅₀ of 72± 21 nM.

IC₅₀ & Target

EC50: 72±21 nM (Dopamine D1 receptor)^[1]

All Dopamine Receptor Isoforms :

In Vitro

(+)-Dihydrexidine hydrochloride (DHX) is a high-potency, bioavailable D1 dopamine receptor agonist. (+)-Dihydrexidine is screened for activity against 40 other binding sites, and is inactive (IC₅₀ greater than 10 microM) against all except D2 dopamine receptors (IC₅₀=130 nM) and alpha 2 adrenoreceptors (IC₅₀=230 nM). Dihydrexidine competes stereoselectively and potently for D1 binding sites in rat striatal membranes labeled with [³H]SCH23390 with an IC₅₀ of about 10 nM compared to about 30 nM for the prototypical D1 agonist SKF38393^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

To examine the functional state of striatal neurons in response to D1 receptor activation, AC5^+/+ and AC5^-/- mice are injected with the D1 agonist (+)-Dihydrexidine (30 mg/kg, i.p.) and obtained the dorso-lateral striatum and NAc, separately, 45 min later for RT-PCR analysis. These experiments reveal that (+)-Dihydrexidine -triggered induction of the immediate early genes, c-fos, egr-1, and junB, in the NAc is markedly enhanced in AC5^-/- mice compared with that in AC5^+/+ mice, while the induction in the dorso-lateral striatum is suppressed in AC5^-/- mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 158704-02-0
Molecular Weight 303.78
Formula C₁₇H₁₈ClNO₂
SMILES

OC1=C(O)C=C(CC[C@]2([H])[C@]3([H])C4=C(C=CC=C4)CN2)C3=C1.Cl
Synonyms

(+)-DAR-0100 hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

Animal Administration^[3]

Mice^[3]
AC5^-/- mice are backcrossed to the C57BL/6J strain for 9 or 10 generations to obtain heterozygote N9 or N10 mice. Mice are treated with (+)-Dihydrexidine (30 mg/kg, i.p.)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (288 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lewis MM, et al. Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitizationdissociates from both receptor occupancy and functional potency. J Pharmacol Exp Ther. 1998 Jul;286(1):345-53. [Content Brief]

[2]. Mottola DM, et al. Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. J Pharmacol Exp Ther. 1992 Jul;262(1):383-93. [Content Brief]

[3]. Kim KS, et al. Adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior. J Neurochem. 2008 Oct;107(1):105-15. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Protocol
Purity & Documentation
References

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(+)-Dihydrexidine hydrochloride

All Dopamine Receptor Isoforms

Biological Activity

Chemical Information

Protocol

Purity & Documentation

References

Calculators

Help & FAQs

(+)-Dihydrexidine hydrochloride Related Classifications

HY-101299 Related Classifications