1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Dihydrexidine hydrochloride

Dihydrexidine hydrochloride (Synonyms: DAR-0100 hydrochloride)

Cat. No.: HY-101299B Purity: 98.90%
Handling Instructions

Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist, with an IC50 of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity. Dihydrexidine hydrochloride can stimulate YAP phosphorylation.

For research use only. We do not sell to patients.

Dihydrexidine hydrochloride Chemical Structure

Dihydrexidine hydrochloride Chemical Structure

CAS No. : 137417-08-4

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Solution
10 mM * 1 mL in DMSO USD 240 In-stock
Estimated Time of Arrival: December 31
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ready for reconstitution
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10 mg USD 550 In-stock
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50 mg USD 1650 In-stock
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100 mg USD 2250 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist, with an IC50 of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity[1][2][3][4]. Dihydrexidine hydrochloride can stimulate YAP phosphorylation[5].

IC50 & Target

IC50: 10 nM (D1 dopamine receptor), D5 dopamine receptor, 660 nM (D2 dopamine receptor)[1]

In Vitro

Dihydrexidine (DAR-0100) strongly increased YAP phosphorylation in U2OS cells[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dihydrexidine hydrochloride has poor oral bioavailability and a relatively short half-life of 1 to 2 h[3].
Dihydrexidine hydrochloride (3 mg/kg; i.p.) produces prominent dopamine D1 receptor agonist effects in vivo[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague–Dawley rats (275-300 g)[4]
Dosage: 3 mg/kg
Administration: Intraperitoneal injection
Result: Produces prominent dopamine D1 receptor agonist effects in vivo.
Clinical Trial
Molecular Weight

303.78

Formula

C₁₇H₁₈ClNO₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (274.31 mM; Need ultrasonic)

H2O : 10 mg/mL (32.92 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2919 mL 16.4593 mL 32.9186 mL
5 mM 0.6584 mL 3.2919 mL 6.5837 mL
10 mM 0.3292 mL 1.6459 mL 3.2919 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.85 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.85 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.85 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Dihydrexidine hydrochloride
Cat. No.:
HY-101299B
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