1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Dihydrexidine hydrochloride

Dihydrexidine hydrochloride (Synonyms: DAR-0100 hydrochloride)

Cat. No.: HY-101299B Purity: 98.90%
Handling Instructions

Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist, with an IC50 of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity.

For research use only. We do not sell to patients.

Dihydrexidine hydrochloride Chemical Structure

Dihydrexidine hydrochloride Chemical Structure

CAS No. : 137417-08-4

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Based on 1 publication(s) in Google Scholar

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Description

Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist, with an IC50 of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity[1][2][3][4].

IC50 & Target

IC50: 10 nM (D1 dopamine receptor), D5 dopamine receptor, 660 nM (D2 dopamine receptor)[1]

In Vivo

Dihydrexidine hydrochloride has poor oral bioavailability and a relatively short half-life of 1 to 2 h[3].
Dihydrexidine hydrochloride (3 mg/kg; i.p.) produces prominent dopamine D1 receptor agonist effects in vivo[4].

Animal Model: Adult male Sprague–Dawley rats (275-300 g)[4]
Dosage: 3 mg/kg
Administration: Intraperitoneal injection
Result: Produces prominent dopamine D1 receptor agonist effects in vivo.
Clinical Trial
Molecular Weight

303.78

Formula

C₁₇H₁₈ClNO₂

CAS No.

137417-08-4

SMILES

OC1=C(O)C=C(CC[[email protected]]2([H])[[email protected]]3([H])C4=C(C=CC=C4)CN2)C3=C1.Cl.[relative stereochemistry]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

DihydrexidineDAR-0100DAR0100DAR 0100Dopamine ReceptordopaminereceptornervoussystemdisordersInhibitorinhibitorinhibit

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Product name:
Dihydrexidine hydrochloride
Cat. No.:
HY-101299B
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