1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Dihydrexidine

Dihydrexidine (Synonyms: DAR-0100)

Cat. No.: HY-101299A
Handling Instructions

Dihydrexidine (DAR-0100) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist with an IC50 of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity.

For research use only. We do not sell to patients.

Dihydrexidine Chemical Structure

Dihydrexidine Chemical Structure

CAS No. : 123039-93-0

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Description

Dihydrexidine (DAR-0100) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist with an IC50 of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity[1][2][3][4].

IC50 & Target

IC50: 10 nM (D1 dopamine receptor), D5 dopamine receptor, 660 nM (D1 dopamine receptor)[1]

In Vivo

Dihydrexidine has poor oral bioavailability and a relatively short half-life of 1 to 2 h[3].
Dihydrexidine (3 mg/kg; i.p.) produces prominent dopamine D1 receptor agonist effects in vivo[4].

Animal Model: Adult male Sprague–Dawley rats (275-300 g)[4]
Dosage: Adult male Sprague–Dawley rats (275-300 g)[4]
Administration: Intraperitoneal injection
Result: Produces prominent dopamine D1 receptor agonist effects in vivo
Clinical Trial
Molecular Weight

267.32

Formula

C₁₇H₁₇NO₂

CAS No.

123039-93-0

SMILES

OC1=C(O)C=C(CC[[email protected]]2([H])[[email protected]]3([H])C4=C(C=CC=C4)CN2)C3=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

DihydrexidineDAR-0100DAR0100DAR 0100Dopamine ReceptordopaminereceptornervoussystemdisordersInhibitorinhibitorinhibit

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Dihydrexidine
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