A-77636 

A-77636 is an orally active, potent, selective and long-acting dopamine D1 receptor agonist (pEC50 = 8.13; EC50 = 1.1 nM). A-77636 shows the highest affinity (pKi = 7.40 ± 0.09; Ki = 39.8 nM) for the dopamine D1 receptor. A-77636 shows antiparkinsonian activity^[1].

A-77636 (0-3.2 μmol/kg, Subcutaneously) elicits rotational behavior in 6-OHDA-lesioned rats (ED₅₀=0.32 μmol/kg s.c.)^[1].
A-77636 (1-10 mg/kg) attenuates addiction-induced locomotor activity in a dose-dependent manner^[2].
A-77636 produce forelimb clonus in rats (ED₅₀=12.3 μmol/kg s.c.) and mice (ED₅₀=12.1 μmol/kg s.c.)^[1].
In marmosets treated with MPTP to induce a parkinsonian-like state, A-77636 (0.5, 1.0 or 2.0 μmol/kg, p.o.) increases locomotor activity and decreases the severity of the parkinsonian-like symptoms: the compound is active after either subcutaneous or oral administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

329.43

C₂₀H₂₇NO₃

778546-51-3

NC[C@@H]1O[C@H](C2(C[C@@H]3C4)C[C@H](C3)C[C@H]4C2)CC5=C(O)C(O)=CC=C51

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kebabian JW, et al. A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. Eur J Pharmacol. 1992 Dec 15;229(2-3):203-9.  [Content Brief]

  [2]. Chausmer AL, et al. Comparison of interactions of D1-like agonists, SKF 81297, SKF 82958 and A-77636, with cocaine: locomotor activity and drug discrimination studies in rodents. Psychopharmacology (Berl). 2002 Jan;159(2):145-53.  [Content Brief]