A-77636 hydrochloride
Based on 1 publication(s) in Google Scholar
A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor.
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- CAS No.: 145307-34-2
- Formule: C20H28ClNO3
- Masse moléculaire:365.89
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) A-77636 hydrochloride
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Activité biologique
Description
IC50 & Target
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D2 Receptor |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male hooded rat[1]
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Dosage:0.1, 0.3 and 1.0 mg/kg
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Administration:S.c.
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Result:Exerted a suppressant effect on food intake, due principally to a reduction in meal size and duration.
Chemical Information
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CAS No. 145307-34-2
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Appearance Solid
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Masse moléculaire 365.89
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Formule C20H28ClNO3
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Color Brown to black
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SMILES
[H]Cl.NC[C@@H]1O[C@@H](CC2=C(O)C(O)=CC=C12)C34C[C@H](C5)C[C@H](C[C@H]5C4)C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Nature
2023 Dec;624(7992):672-681. PMID: 37935376
Solvant et solubilité
In Vitro:
DMSO : 33 mg/mL (90.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Kebabian JW, et al. A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. Eur J Pharmacol. 1992;229(2-3):203-209. [Content Brief]
[2]. Smith LA, et al. The actions of a D-1 agonist in MPTP treated primates show dependence on both D-1 and D-2 receptor function and tolerance on repeated administration. J Neural Transm (Vienna). 2002;109(2):123-140. [Content Brief]
[3]. Cooper SJ, et al. The anorectic effect of the selective dopamine D1-receptor agonist A-77636 determined by meal pattern analysis in free-feeding rats. Eur J Pharmacol. 2006;532(3):253-257. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7331 mL | 13.6653 mL | 27.3306 mL | 68.3265 mL |
| 5 mM | 0.5466 mL | 2.7331 mL | 5.4661 mL | 13.6653 mL | |
| 10 mM | 0.2733 mL | 1.3665 mL | 2.7331 mL | 6.8327 mL | |
| 15 mM | 0.1822 mL | 0.9110 mL | 1.8220 mL | 4.5551 mL | |
| 20 mM | 0.1367 mL | 0.6833 mL | 1.3665 mL | 3.4163 mL | |
| 25 mM | 0.1093 mL | 0.5466 mL | 1.0932 mL | 2.7331 mL | |
| 30 mM | 0.0911 mL | 0.4555 mL | 0.9110 mL | 2.2776 mL | |
| 40 mM | 0.0683 mL | 0.3416 mL | 0.6833 mL | 1.7082 mL | |
| 50 mM | 0.0547 mL | 0.2733 mL | 0.5466 mL | 1.3665 mL | |
| 60 mM | 0.0456 mL | 0.2278 mL | 0.4555 mL | 1.1388 mL | |
| 80 mM | 0.0342 mL | 0.1708 mL | 0.3416 mL | 0.8541 mL |
A-77636 hydrochloride Related Classifications
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