2. Neuronal Signaling NF-κB
  3. Amyloid-β Keap1-Nrf2
  4. Aβ-IN-6

Aβ-IN-6 reduces pro-inflammatory cytokine release from microglia cells. Aβ-IN-6 significantly induces Nrf2 nuclear translocation and hamperes Aβ oligomers formation. Aβ-IN-6 exerts a consistent neuroprotective effect by modulating the redox-sensitive signalling pathways in vivo oxidative stress model. Aβ-IN-6 is an orally active and has antiinflammatory, Antioxidant and Anti-oligomeric activity. Aβ-IN-6 has the potential for Alzheimer's disease (AD) research.

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Aβ-IN-6 Chemical Structure

Aβ-IN-6 Chemical Structure

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Aβ-IN-6 Related Antibodies

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Description

Aβ-IN-6 reduces pro-inflammatory cytokine release from microglia cells. Aβ-IN-6 significantly induces Nrf2 nuclear translocation and hamperes Aβ oligomers formation. Aβ-IN-6 exerts a consistent neuroprotective effect by modulating the redox-sensitive signalling pathways in vivo oxidative stress model. Aβ-IN-6 is an orally active and has antiinflammatory, Antioxidant and Anti-oligomeric activity. Aβ-IN-6 has the potential for Alzheimer's disease (AD) research[1].

In Vitro

Aβ-IN-6 (compound 4; 1-20 μM; 24 h) markedly reduces microglia viability starting from the concentration of 5 μM[1].
Aβ-IN-6 (1.25-40 μM; 24 h) causes significant cytotoxicity at concentrations higher than 2.5 μM in SH-SY5Y neuroblastoma cells[1].
Aβ-IN-6 (2.5 μM; 3 h) significantly induces Nrf2 nuclear translocation[1].
Aβ-IN-6 (2.5 μM) markedly suppresses the LPS-induced increase of mRNA levels of the two cytokines and NLRP3[1].
Aβ-IN-6 (1, 2.5 μM; protreamt for 1 h then stimulated with LPS for 24 h) significantly decreases LPS treatment induced the release of TNF-α and IL-1β[1].
Aβ-IN-6 (2.5 μM; for 24 h) before tert-butyl hydroperoxide (t-BuOOH; 50 μM for 30 min) reduces ROS formation with inhibition of around 18%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aβ-IN-6 Related Antibodies

Cell Viability Assay[1]

Cell Line: Microglia
Concentration: 1-20 μM
Incubation Time: 24 h
Result: Markedly reduced microglia viability starting from the concentration of 5 μM.

Cell Cytotoxicity Assay[1]

Cell Line: SH-SY5Y neuroblastoma cells
Concentration: 1.25, 2.5, 5, 10, 20, 40 μM
Incubation Time: 24 h
Result: Recorded significant cytotoxicity at concentrations higher than 2.5 μM.

Western Blot Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 2.5 μM 3 h Significantly induced Nrf2 nuclear translocation. SH-SY5Y cells 2.5 μM
Incubation Time: 3 h
Result: Significantly induced Nrf2 nuclear translocation.

RT-PCR[1]

Cell Line: Microglia
Concentration: 2.5 μM
Incubation Time: Pretreated for 1 h and then stimulated with 100 ng/mL LPS for 6 h
Result: Markedly suppressed the LPS-induced increase of mRNA levels of the two cytokines and NLRP3, confirming the anti-inflammatory properties.
In Vivo

Aβ-IN-6 (compound 4; 10 μM; added to standard food) efficiently restored the increased ROS level in larval muscles and brains under neurodegenerative conditions (D-spastin loss of function model) to that observed for the control in Spastin Drosophila model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Spastin Drosophila model[1]
Dosage: 10 μM
Administration: Added to standard food (dissolved in DMSO)
Result: Efficiently restored the increased ROS level in larval muscles and brains under neurodegenerative conditions (D-spastin loss of function model) to that observed for the control.
Significantly ameliorated the phenotype associated with spastin reduction.
Molecular Weight

473.56

Formula

C28H31N3O4
SMILES

CCCCN1C=C(N=N1)C/C(C(/C=C/C2=CC=C(C=C2)OC)=O)=C(\C=C\C3=CC=C(C=C3)OC)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Aβ-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aβ-IN-6Amyloid-βKeap1-Nrf2β-amyloid peptideAβAbetapro-inflammatorymicroglia cellsNrf2nuclear translocationAβ oligomerneuroprotectiveredox-sensitiveoxidative stressantiinflammatoryAntioxidantAnti-oligomericAlzheimer's diseaseADInhibitorinhibitorinhibit

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