Aβ-IN-6
Aβ-IN-6 reduces pro-inflammatory cytokine release from microglia cells. Aβ-IN-6 significantly induces Nrf2 nuclear translocation and hamperes Aβ oligomers formation. Aβ-IN-6 exerts a consistent neuroprotective effect by modulating the redox-sensitive signalling pathways in vivo oxidative stress model. Aβ-IN-6 is an orally active and has antiinflammatory, Antioxidant and Anti-oligomeric activity. Aβ-IN-6 has the potential for Alzheimer's disease (AD) research.
For research use only. We do not sell to patients.
- CAS No.: 3043752-01-5
- Formula: C28H31N3O4
- Molecular Weight:473.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Aβ-IN-6 (compound 4; 1-20 μM; 24 h) markedly reduces microglia viability starting from the concentration of 5 μM[1].
Aβ-IN-6 (1.25-40 μM; 24 h) causes significant cytotoxicity at concentrations higher than 2.5 μM in SH-SY5Y neuroblastoma cells[1].
Aβ-IN-6 (2.5 μM; 3 h) significantly induces Nrf2 nuclear translocation[1].
Aβ-IN-6 (2.5 μM) markedly suppresses the LPS-induced increase of mRNA levels of the two cytokines and NLRP3[1].
Aβ-IN-6 (1, 2.5 μM; protreamt for 1 h then stimulated with LPS for 24 h) significantly decreases LPS treatment induced the release of TNF-α and IL-1β[1].
Aβ-IN-6 (2.5 μM; for 24 h) before tert-butyl hydroperoxide (t-BuOOH; 50 μM for 30 min) reduces ROS formation with inhibition of around 18%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Microglia
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Concentration:1-20 μM
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Incubation Time:24 h
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Result:Markedly reduced microglia viability starting from the concentration of 5 μM.
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Cell Line:SH-SY5Y neuroblastoma cells
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Concentration:1.25, 2.5, 5, 10, 20, 40 μM
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Incubation Time:24 h
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Result:Recorded significant cytotoxicity at concentrations higher than 2.5 μM.
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Cell Line:SH-SY5Y cells
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Concentration:2.5 μM 3 h Significantly induced Nrf2 nuclear translocation. SH-SY5Y cells 2.5 μM
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Incubation Time:3 h
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Result:Significantly induced Nrf2 nuclear translocation.
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Cell Line:Microglia
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Concentration:2.5 μM
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Incubation Time:Pretreated for 1 h and then stimulated with 100 ng/mL LPS for 6 h
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Result:Markedly suppressed the LPS-induced increase of mRNA levels of the two cytokines and NLRP3, confirming the anti-inflammatory properties.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Spastin Drosophila model[1]
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Dosage:10 μM
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Administration:Added to standard food (dissolved in DMSO)
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Result:Efficiently restored the increased ROS level in larval muscles and brains under neurodegenerative conditions (D-spastin loss of function model) to that observed for the control.
Significantly ameliorated the phenotype associated with spastin reduction.
Chemical Information
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CAS No. 3043752-01-5
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Molecular Weight 473.56
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Formula C28H31N3O4
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SMILES
CCCCN1C=C(N=N1)C/C(C(/C=C/C2=CC=C(C=C2)OC)=O)=C(\C=C\C3=CC=C(C=C3)OC)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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