Aβ-IN-6
Aβ-IN-6 reduces pro-inflammatory cytokine release from microglia cells. Aβ-IN-6 significantly induces Nrf2 nuclear translocation and hamperes Aβ oligomers formation. Aβ-IN-6 exerts a consistent neuroprotective effect by modulating the redox-sensitive signalling pathways in vivo oxidative stress model. Aβ-IN-6 is an orally active and has antiinflammatory, Antioxidant and Anti-oligomeric activity. Aβ-IN-6 has the potential for Alzheimer's disease (AD) research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 3043752-01-5
- Formel: C28H31N3O4
- Molecular Weight:473.56
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Aβ-IN-6 (compound 4; 1-20 μM; 24 h) markedly reduces microglia viability starting from the concentration of 5 μM[1].
Aβ-IN-6 (1.25-40 μM; 24 h) causes significant cytotoxicity at concentrations higher than 2.5 μM in SH-SY5Y neuroblastoma cells[1].
Aβ-IN-6 (2.5 μM; 3 h) significantly induces Nrf2 nuclear translocation[1].
Aβ-IN-6 (2.5 μM) markedly suppresses the LPS-induced increase of mRNA levels of the two cytokines and NLRP3[1].
Aβ-IN-6 (1, 2.5 μM; protreamt for 1 h then stimulated with LPS for 24 h) significantly decreases LPS treatment induced the release of TNF-α and IL-1β[1].
Aβ-IN-6 (2.5 μM; for 24 h) before tert-butyl hydroperoxide (t-BuOOH; 50 μM for 30 min) reduces ROS formation with inhibition of around 18%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Microglia
-
Concentration:1-20 μM
-
Incubation Time:24 h
-
Result:Markedly reduced microglia viability starting from the concentration of 5 μM.
-
Cell Line:SH-SY5Y neuroblastoma cells
-
Concentration:1.25, 2.5, 5, 10, 20, 40 μM
-
Incubation Time:24 h
-
Result:Recorded significant cytotoxicity at concentrations higher than 2.5 μM.
-
Cell Line:SH-SY5Y cells
-
Concentration:2.5 μM 3 h Significantly induced Nrf2 nuclear translocation. SH-SY5Y cells 2.5 μM
-
Incubation Time:3 h
-
Result:Significantly induced Nrf2 nuclear translocation.
-
Cell Line:Microglia
-
Concentration:2.5 μM
-
Incubation Time:Pretreated for 1 h and then stimulated with 100 ng/mL LPS for 6 h
-
Result:Markedly suppressed the LPS-induced increase of mRNA levels of the two cytokines and NLRP3, confirming the anti-inflammatory properties.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Spastin Drosophila model[1]
-
Dosage:10 μM
-
Administration:Added to standard food (dissolved in DMSO)
-
Result:Efficiently restored the increased ROS level in larval muscles and brains under neurodegenerative conditions (D-spastin loss of function model) to that observed for the control.
Significantly ameliorated the phenotype associated with spastin reduction.
Chemical Information
-
CAS. Nr. 3043752-01-5
-
Molecular Weight 473.56
-
Formel C28H31N3O4
-
SMILES
CCCCN1C=C(N=N1)C/C(C(/C=C/C2=CC=C(C=C2)OC)=O)=C(\C=C\C3=CC=C(C=C3)OC)O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Aβ-IN-6 Related Classifications
HY-149246 Related Classifications
Powered by Bioz