1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. Dazoxiben

Dazoxiben 

Cat. No.: HY-106067A Purity: 99.87%
Handling Instructions

Dazoxiben is a potent and orally active thromboxane (TX) synthase inhibitor.

For research use only. We do not sell to patients.

Dazoxiben Chemical Structure

Dazoxiben Chemical Structure

CAS No. : 74226-22-5

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Based on 1 publication(s) in Google Scholar

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Description

Dazoxiben is a potent and orally active thromboxane (TX) synthase inhibitor[1].

IC50 & Target

Thromboxane (TX) synthase[1]

In Vitro

Dazoxiben inhibits TXB2 production in clotting human whole blood with an IC50 of 0.3 μM and causes parallel enhancement of PGE2 greater than PGF2 alpha greater than 6-keto-PGF1 alpha production[1].
Dazoxiben inhibits TXB2 production in rat kidney glomeruli with an IC50 of 1.60 μM) than in rat whole blood (IC50= 0.32μM), and is not associated with changes in PGE2, PGF2 alpha and 6-keto-PGF1 alpha production[1].

In Vivo

Dazoxiben (intraperitoneal administration; 100 μg/kg) produces a marked prolongation of the tail bleeding time with 96.8 ± 10.8 secs[2].

Molecular Weight

268.70

Formula

C₁₂H₁₃ClN₂O₃

CAS No.

74226-22-5

SMILES

OC(C1=CC=C(OCCN2C=CN=C2)C=C1)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

DazoxibenProstaglandin ReceptorInhibitorinhibitorinhibit

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