DMNB (Synonyms: 6-Nitroveratraldehyde)

Cat. No.: HY-100705 Purity: 98.76%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DMNB (6-Nitroveratraldehyde), a precursor, can be used for the synthesis no-carrier-added 6-[¹⁸F]fluoro-L-DOPA (6-FDOPA). No-Carrier-Added (NCA) 6-[18F]fluoro-L-dopa (6-FDOPA) is being produced routinely for PET investigations of dopaminergic systems.

For research use only. We do not sell to patients.

DMNB Chemical Structure

CAS No. : 20357-25-9

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50 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 75	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
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Description

Molecular Weight

211.17

Formula

C₉H₉NO₅

CAS No.

20357-25-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=CC1=CC(OC)=C(OC)C=C1[N+]([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (473.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7355 mL	23.6776 mL	47.3552 mL
5 mM	0.9471 mL	4.7355 mL	9.4710 mL
10 mM	0.4736 mL	2.3678 mL	4.7355 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (11.84 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.76%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (252 KB) LCMS (276 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.7355 mL	23.6776 mL	47.3552 mL	118.3880 mL
	5 mM	0.9471 mL	4.7355 mL	9.4710 mL	23.6776 mL
	10 mM	0.4736 mL	2.3678 mL	4.7355 mL	11.8388 mL
	15 mM	0.3157 mL	1.5785 mL	3.1570 mL	7.8925 mL
	20 mM	0.2368 mL	1.1839 mL	2.3678 mL	5.9194 mL
	25 mM	0.1894 mL	0.9471 mL	1.8942 mL	4.7355 mL
	30 mM	0.1579 mL	0.7893 mL	1.5785 mL	3.9463 mL
	40 mM	0.1184 mL	0.5919 mL	1.1839 mL	2.9597 mL
	50 mM	0.0947 mL	0.4736 mL	0.9471 mL	2.3678 mL
	60 mM	0.0789 mL	0.3946 mL	0.7893 mL	1.9731 mL
	80 mM	0.0592 mL	0.2960 mL	0.5919 mL	1.4799 mL
	100 mM	0.0474 mL	0.2368 mL	0.4736 mL	1.1839 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DMNB20357-25-96-NitroveratraldehydeInhibitorinhibitorinhibit

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