2. Epigenetics
  3. DNA Methyltransferase
  4. DNMT3A-IN-2

DNMT3A-IN-2 (compound 1a) is a hydrophthalazinone-based inhibitor of DNA methyltransferase 3A (DNMT3A) (IC50: 14 μM) against S-adenosylmethionine (SAM) has a Ki of 9.16-18.85 μM..

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DNMT3A-IN-2 Chemical Structure

DNMT3A-IN-2 Chemical Structure

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DNMT3A-IN-2 Related Antibodies

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Description

DNMT3A-IN-2 (compound 1a) is a hydrophthalazinone-based inhibitor of DNA methyltransferase 3A (DNMT3A) (IC50: 14 μM) against S-adenosylmethionine (SAM) has a Ki of 9.16-18.85 μM.[14][1].

IC50 & Target

DNMT3A

14 μM (IC50)

In Vivo

DNMT3A-IN-2 significantly reduces DNMT3A activity and demonstrates lower cytotoxicity in a mouse model of acute myeloid leukemimice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

584.71

Formula

C33H40N6O4
SMILES

[H][C@]12CC=CC[C@]1(C(N(N=C2C3=CC=C(C(OCCCCOC4=CC=C(C=C4)C5=NNN=N5)=C3)OC)C6CCCCCC6)=O)[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DNMT3A-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DNMT3A-IN-2DNA MethyltransferaseDNMTsDNA MTasesAcute Myeloid Leukemia (AML)， S-Adenosyl MethionineInhibitorinhibitorinhibit

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