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DSP-4 hydrochloride  (Synonyms: Neurotoxin DSP 4 hydrochloride)

Cat. No.: HY-103210 Purity: ≥98.0%
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DSP-4 hydrochloride is a highly and selective adrenergic neurotoxin. DSP-4 hydrochloride can cross the blood brain barrier. DSP-4 hydrochloride can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons.

For research use only. We do not sell to patients.

DSP-4 hydrochloride Chemical Structure

DSP-4 hydrochloride Chemical Structure

CAS No. : 40616-75-9

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 61 In-stock
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10 mg USD 77 In-stock
50 mg USD 198 In-stock
100 mg USD 308 In-stock
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Based on 1 publication(s) in Google Scholar

DSP-4 hydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE DSP-4 hydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DSP-4 hydrochloride is a highly and selective adrenergic neurotoxin. DSP-4 hydrochloride can cross the blood brain barrier. DSP-4 hydrochloride can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons[1][2].

In Vivo

DSP-4 hydrochloride (i.p.; 50 mg/kg; single) destroys the LC neurons and fibers[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: rats[1]
Dosage: 50 mg/kg
Administration: intraperitoneal , single
Result: Not visualized large projection neurons and the fibers of the LC.
Molecular Weight

313.06

Formula

C11H16BrCl2N
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCN(CCCl)CC1=CC=CC=C1Br.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (399.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (159.71 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1943 mL 15.9714 mL 31.9428 mL
5 mM 0.6389 mL 3.1943 mL 6.3886 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (6.64 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (6.64 mM); Clear solution

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (159.71 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.1943 mL 15.9714 mL 31.9428 mL 79.8569 mL
5 mM 0.6389 mL 3.1943 mL 6.3886 mL 15.9714 mL
10 mM 0.3194 mL 1.5971 mL 3.1943 mL 7.9857 mL
15 mM 0.2130 mL 1.0648 mL 2.1295 mL 5.3238 mL
20 mM 0.1597 mL 0.7986 mL 1.5971 mL 3.9928 mL
25 mM 0.1278 mL 0.6389 mL 1.2777 mL 3.1943 mL
30 mM 0.1065 mL 0.5324 mL 1.0648 mL 2.6619 mL
40 mM 0.0799 mL 0.3993 mL 0.7986 mL 1.9964 mL
50 mM 0.0639 mL 0.3194 mL 0.6389 mL 1.5971 mL
60 mM 0.0532 mL 0.2662 mL 0.5324 mL 1.3309 mL
80 mM 0.0399 mL 0.1996 mL 0.3993 mL 0.9982 mL
100 mM 0.0319 mL 0.1597 mL 0.3194 mL 0.7986 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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DSP-4 hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DSP-440616-75-9Neurotoxin DSP 4DSP4DSP 4Neurotoxin DSP4Neurotoxin DSP-4Othersinferior colliculus (IC)locus coeruleus (LC)adrenergic neurotoxinblood brain barriernoradrenergic neuronsInhibitorinhibitorinhibit

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