PDE4C - phosphodiesterase 4C Gene

Also Known as DPDE1; PDE21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5143

About PDE4C

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,207,965-18,248,433 (from NCBI)

This gene has 14 transcripts (splice variants), 90 orthologues and 20 paralogues. Broad expression in placenta (RPKM 1.5), endometrium (RPKM 1.5) and 20 other tissues.

Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

PDE4C Products (7)

mRNA Protein Name
NM_000923.6 NP_000914.2 cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1
NM_001098818.4 NP_001092288.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 3
NM_001098819.4 NP_001092289.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 2
NM_001330172.2 NP_001317101.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1
NM_001369701.2 NP_001356630.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 4
NM_001395274.1 NP_001382203.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 2
NM_001414480.1 NP_001401409.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
7843419 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE4C Protein Structure

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (387 - 631)

  • 0
  • 200
  • 400
  • 600
  • 712 a.a.
Protein Preferred Names Protein Names

cAMP-specific 3',5'-cyclic phosphodiesterase 4C

  • dunce-like phosphodiesterase E1

Related Diseases

Diseases Alias
Ocular Hypotension

  • Hypotony Of Eye
Retinitis Pigmentosa 73

  • RP73

  • Retinitis Pigmentosa, Type 73
Acrodysostosis

  • Acrodysplasia

  • Arkless-Graham Syndrome

  • Maroteaux-Malamut Syndrome

  • Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome

  • Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-108047 MK-0873 Inhibitor 95.0% Phase 2
HY-131707 LEO 39652 Inhibitor 99.40% Phase 1
HY-201403 LY2775240 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-128358 MR-L2 Activator 98.63% Unkown
HY-119190 PF-06445974 Inhibitor 98.59% Unkown
HY-103050 ML-030 Inhibitor 99.28% Unkown
HY-100246 CI-1044 Inhibitor 98.02% Unkown
HY-114052 NVP-ABE171 Inhibitor / Unkown
HY-179504 PDE4B-IN-6 Inhibitor / Unkown
HY-RS10224 PDE4C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-119799 UK-500001 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PDE4C VGNC VGNC:80650
Rattus norvegicus PDE4C RGD RGD:727918
Bos taurus PDE4C VGNC VGNC:50242
Canis familiaris PDE4C VGNC VGNC:49938
Mus musculus PDE4C MGD MGI:99556
Others PDE4C NCBI