SLC38A5 - solute carrier family 38 member 5 Gene

Also Known as SN2; JM24; SNAT5; pp7194

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 92745

About SLC38A5

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,458,544-48,470,260 (from NCBI)

This gene has 13 transcripts (splice variants), 218 orthologues and 15 paralogues. Broad expression in pancreas (RPKM 19.9), bone marrow (RPKM 15.5) and 18 other tissues.

Summary

The protein encoded by this gene is a system N sodium-coupled Amino acid Transporter. The encoded protein transports glutamine, asparagine, histidine, serine, alanine, and glycine across the cell membrane, but does not transport charged Amino acids, imino acids, or N-alkylated Amino acids. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Aug 2013]

SLC38A5 Products (1)

mRNA	Protein	Name
NM_033518.4	NP_277053.2	sodium-coupled neutral amino acid transporter 5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables L-asparagine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	11243884	GOA
enables L-glutamine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	11243884	GOA
enables L-histidine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	11243884	GOA
enables L-serine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	11243884	GOA
enables alanine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	11243884	GOA
enables glycine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	11243884	GOA
enables neutral amino acid, sodium:proton antiporter activity	IDA IDA: Inferred from direct assay	11243884	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in L-alanine transmembrane transport	IMP IMP: Inferred from mutant phenotype	11243884	GOA
involved in L-histidine transmembrane transport	IMP IMP: Inferred from mutant phenotype	11243884	GOA
involved in asparagine transmembrane transport	IMP IMP: Inferred from mutant phenotype	11243884	GOA
involved in glutamine transport	IMP IMP: Inferred from mutant phenotype	11243884	GOA
involved in glycine transport	IMP IMP: Inferred from mutant phenotype	11243884	GOA
involved in neutral amino acid transport	IDA IDA: Inferred from direct assay	11243884	GOA
involved in serine transport	IMP IMP: Inferred from mutant phenotype	11243884	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC38A5 Protein Structure

Aa_trans

0
100
200
300
400
472 a.a.

Protein Preferred Names	Protein Names
sodium-coupled neutral amino acid transporter 5	solute carrier family 38 (amino acid transporter), member 5

Related Diseases

Diseases	Alias
Hepatic Encephalopathy	Encephalopathy, Hepatic Portal-Systemic Encephalopathy Hepatoencephalopathy He - [Hepatic Encephalopathy] Hepatic Encephalopathy Nos Hepatic Encephalopathy, Stage Unspecified Hepatic Coma Hepatocerebral Encephalopathy Hepatocerebral Intoxication
Mahvash Disease	Gcgr-Related Hyperglucagonemia MVAH Alpha-Cell Hyperplasia With Glucagonemia Nesidioblastosis, Alpha Cell Hyperplasia, Microglucagonoma, And Nonfunctioning Islet Cell Tumor Nesidioblastosis Alpha Cell Hyperplasia Microglucagonoma And Nonfunctioning Islet Cell Tumor
Brain Edema	Cerebral Edema Intracranial Swelling Wet Brain
Osteogenesis Imperfecta, Type Iv	Osteogenesis Imperfecta Type 4 Osteogenesis Imperfecta Type Iv OI4 Oi, Type Iv Osteogenesis Imperfecta With Normal Sclerae Oi Type Iv Oi Type 4 Osteogenesis Imperfecta With Normal Sclera Common Variable Oi With Normal Sclerae Osteogenesis Imperfecta 4 Oi-Iv
Osteogenesis Imperfecta, Type Iii	Osteogenesis Imperfecta Type Iii OI3 Oi, Type Iii Osteogenesis Imperfecta Type 3 Oi Type Iii Oi Type 3 Progressive Deforming Osteogenesis Imperfecta Severe Osteogenesis Imperfecta Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae Progressively Deforming Osteogenesis Imperfecta With Normal Sclera Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae Progressively Deforming Oi Osteogenesis Imperfecta 3 Oi-Iii Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae
Iminoglycinuria	Iminoglycinuria, Digenic IG

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13223	SLC38A5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC38A5	MGD	MGI:2148066
Bos taurus	SLC38A5	VGNC	VGNC:34852
Felis catus	SLC38A5	VGNC	VGNC:65348
Canis familiaris	SLC38A5	VGNC	VGNC:54601
Rattus norvegicus	SLC38A5	RGD	RGD:620702
Macaca mulatta	SLC38A5	VGNC	VGNC:77505
Others	SLC38A5	NCBI