1. Protein Tyrosine Kinase/RTK Apoptosis
  2. Ephrin Receptor Apoptosis
  3. Ifabotuzumab

Ifabotuzumab  (Synonyms: KB004)

Cat. No.: HY-P99655 Purity: ≥95.0%
COA

Ifabotuzumab (KB004) is an IgG1κ antibody targeting EphA3 (KD=610 pM). Ifabotuzumab induces tumor cell apoptosis, activates Antibody-dependent cell mediated cytotoxicity (ADCC), and damages tumor vasculature. Ifabotuzumab reduces human idiopathic pulmonary fibrosis (IPF) CCR10+ cells and improves pulmonary fibrosis.

For research use only. We do not sell to patients.

Ifabotuzumab Chemical Structure

Ifabotuzumab Chemical Structure

CAS No. : 2147698-66-4

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5 mg USD 740 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Ifabotuzumab (KB004) is an IgG1κ antibody targeting EphA3 (KD=610 pM). Ifabotuzumab induces tumor cell apoptosis, activates Antibody-dependent cell mediated cytotoxicity (ADCC), and damages tumor vasculature. Ifabotuzumab reduces human idiopathic pulmonary fibrosis (IPF) CCR10+ cells and improves pulmonary fibrosis[1][2].

Isotype

Human IgG1 kappa

Recommend Isotype Controls
Species

Humanized

In Vivo

Ifabotuzumab (5 mg/kg; i.p.; twice weekly for 5 weeks) improve pulmonary fibrosis in human mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Humanized NSG mice with lung fibrosis[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; twice weekly for 5 weeks
Result: Significantly reduced hydroxyproline to levels and IL-6 transcript levels.
Significantly reduced the total number of CCR10+EphA3+, as well as Lin-CCR10+ cells.
Clinical Trial
CAS No.
Unlabeled CAS

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ifabotuzumab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: ≥95.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Ifabotuzumab
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HY-P99655
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