L-Citrulline-d₄

Name: L-Citrulline-d 4
Brand: MedChemExpress
SKU: HY-N0391S4
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0391S4 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Citrulline-d₄ is the deuterium labeled L-Citrulline. L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.

For research use only. We do not sell to patients.

L-Citrulline-d<sub>4</sub> Chemical Structure

L-Citrulline-d₄ Chemical Structure

CAS No. : 1217474-00-4

Size	Price	Stock	Quantity
1 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of L-Citrulline-d₄:

L-Citrulline In-stock

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

179.21

Formula

C₆H₉D₄N₃O₃

CAS No.

1217474-00-4

Appearance

Solid

Color

White to off-white

SMILES

NC(NC([2H])([2H])C([2H])([2H])C[C@H](N)C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (279.00 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.5800 mL	27.9002 mL	55.8005 mL
5 mM	1.1160 mL	5.5800 mL	11.1601 mL
10 mM	0.5580 mL	2.7900 mL	5.5800 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (270 KB) SDS (0 KB)

COA (247 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.5800 mL	27.9002 mL	55.8005 mL	139.5011 mL
	5 mM	1.1160 mL	5.5800 mL	11.1601 mL	27.9002 mL
	10 mM	0.5580 mL	2.7900 mL	5.5800 mL	13.9501 mL
	15 mM	0.3720 mL	1.8600 mL	3.7200 mL	9.3001 mL
	20 mM	0.2790 mL	1.3950 mL	2.7900 mL	6.9751 mL
	25 mM	0.2232 mL	1.1160 mL	2.2320 mL	5.5800 mL
	30 mM	0.1860 mL	0.9300 mL	1.8600 mL	4.6500 mL
	40 mM	0.1395 mL	0.6975 mL	1.3950 mL	3.4875 mL
	50 mM	0.1116 mL	0.5580 mL	1.1160 mL	2.7900 mL
	60 mM	0.0930 mL	0.4650 mL	0.9300 mL	2.3250 mL
	80 mM	0.0698 mL	0.3488 mL	0.6975 mL	1.7438 mL
	100 mM	0.0558 mL	0.2790 mL	0.5580 mL	1.3950 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.