L-シトルリン
Based on 6 publication(s) in Google Scholar
L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.96%
- CAS 番号: 372-75-8
- 分子式: C6H13N3O3
- 分子量:175.19
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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溶剤 & 溶解度
- 純度とドキュメンテーション
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MedChemExpress（MCE）の使用を引用している文献 L-Citrulline
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- NPJ Biofilms Microbiomes. 2025 Oct 30;11(1):202. [Abstract]
- Front Immunol. 2022 Aug 5:13:918241. [Abstract]
- PLoS Biol. 2024 Jun 27;22(6):e3002672. [Abstract]
- Exp Ther Med. 2022 Aug 22;24(4):632. [Abstract]
- bioRxiv. 2024 Apr 3:2023.06.02.542933. [Abstract]
Customer Validation & Images
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Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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Human Endogenous Metabolite |
L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway. L-Citrulline is also obtained during the degradation of asymmetric dimethylarginine (ADMA), the process catalyzed by dimethylarginine dimethylaminohydrolase (DDAH), yielding dimethylamine (DMA) as a coproduct[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 372-75-8
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性状 Solid
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分子量 175.19
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分子式 C6H13N3O3
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Color White to off-white
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SMILES
N[C@@H](CCCNC(N)=O)C(O)=O
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別名
L-Citrulline
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Structure Classification
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (6)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
NPJ Biofilms Microbiomes
L-citrulline protects testicular Sertoli cell function by mitigating DNA damage via the gut-testis axis of sheep fed a high-concentrate diet. [Abstract]2025 Oct 30;11(1):202. PMID: 41168195
L-Citrulline purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2025 Oct 30;11(1):202. [Abstract]
L-Citrulline (Citr; 5 mM; 48 h). The representative images of ROS immunofluorescence of TM4 cell line in each group. Citr, treated with Citr; Sucrose, treated with Sucrose; Sucrose +H2O2, treated with Sucrose and Citr.
L-Citrulline purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2025 Oct 30;11(1):202. [Abstract]
L-Citrulline (Citr; 5 mM; 48 h). Western blot of γH2AX and GAPDH in each indicated group.
L-Citrulline purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2025 Oct 30;11(1):202. [Abstract]
L-Citrulline (Citr; 5 mM; 48 h). RT-qPCR analyzing the expression of Pcna and Gtf2h5 in each indicated group (n = 3).
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Front Immunol
DMGV Is a Rheostat of T Cell Survival and a Potential Therapeutic for Inflammatory Diseases and Cancers. [Abstract]2022 Aug 5:13:918241. PMID: 35990633 -
PLoS Biol
2024 Jun 27;22(6):e3002672. PMID: 38935621 -
Exp Ther Med
Citrulline protects against LPS‑induced acute lung injury by inhibiting ROS/NLRP3‑dependent pyroptosis and apoptosis via the Nrf2 signaling pathway. [Abstract]2022 Aug 22;24(4):632. PMID: 36160882
L-Citrulline purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2022 Aug 22;24(4):632. [Abstract]
L-Citrulline (Cit; 1 g/kg/day; ip). Representative histological changes of lung tissue. Scale bar, 100 µm.
L-Citrulline purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2022 Aug 22;24(4):632. [Abstract]
L-Citrulline (Cit; 1 g/kg/day; ip). Representative macrophage infiltration shown as F4/80-positive cells. Sections were stained with primary antibodies against F4/80 (red), while the nucleus was stained with DAPI (blue). Scale bar, 100 µm. LPS, lipopolysaccharide; Con, control; Cit, citrulline.
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bioRxiv
An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence in C. elegans. [Abstract]2024 Apr 3:2023.06.02.542933. PMID: 37333363
溶剤 & 溶解度
H2O : ≥ 50 mg/mL (285.40 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (570.81 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.7081 mL | 28.5404 mL | 57.0809 mL | 142.7022 mL |
| 5 mM | 1.1416 mL | 5.7081 mL | 11.4162 mL | 28.5404 mL | |
| 10 mM | 0.5708 mL | 2.8540 mL | 5.7081 mL | 14.2702 mL | |
| 15 mM | 0.3805 mL | 1.9027 mL | 3.8054 mL | 9.5135 mL | |
| 20 mM | 0.2854 mL | 1.4270 mL | 2.8540 mL | 7.1351 mL | |
| 25 mM | 0.2283 mL | 1.1416 mL | 2.2832 mL | 5.7081 mL | |
| 30 mM | 0.1903 mL | 0.9513 mL | 1.9027 mL | 4.7567 mL | |
| 40 mM | 0.1427 mL | 0.7135 mL | 1.4270 mL | 3.5676 mL | |
| 50 mM | 0.1142 mL | 0.5708 mL | 1.1416 mL | 2.8540 mL | |
| 60 mM | 0.0951 mL | 0.4757 mL | 0.9513 mL | 2.3784 mL | |
| 80 mM | 0.0714 mL | 0.3568 mL | 0.7135 mL | 1.7838 mL | |
| 100 mM | 0.0571 mL | 0.2854 mL | 0.5708 mL | 1.4270 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Citrulline 関連分類
HY-N0391 関連分類
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