2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. L-Citrulline

L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.

For research use only. We do not sell to patients.

CAS No. : 372-75-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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500 mg In-stock
1 g In-stock
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10 g   Get quote  

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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of L-Citrulline:

L-Citrulline Related Antibodies

Top Publications Citing Use of Products

    L-Citrulline purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2025 Oct 30;11(1):202.  [Abstract]

    L-Citrulline (Citr; 5 mM; 48 h). The representative images of ROS immunofluorescence of TM4 cell line in each group. Citr, treated with Citr; Sucrose, treated with Sucrose; Sucrose +H2O2, treated with Sucrose and Citr.

    L-Citrulline purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2025 Oct 30;11(1):202.  [Abstract]

    L-Citrulline (Citr; 5 mM; 48 h). Western blot of γH2AX and GAPDH in each indicated group.

    L-Citrulline purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2025 Oct 30;11(1):202.  [Abstract]

    L-Citrulline (Citr; 5 mM; 48 h). RT-qPCR analyzing the expression of Pcna and Gtf2h5 in each indicated group (n = 3).

    L-Citrulline purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2022 Aug 22;24(4):632.

    L-Citrulline (Cit; 1 g/kg/day; ip). Representative histological changes of lung tissue. Scale bar, 100 µm.

    L-Citrulline purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2022 Aug 22;24(4):632.

    L-Citrulline (Cit; 1 g/kg/day; ip). Representative macrophage infiltration shown as F4/80-positive cells. Sections were stained with primary antibodies against F4/80 (red), while the nucleus was stained with DAPI (blue). Scale bar, 100 µm. LPS, lipopolysaccharide; Con, control; Cit, citrulline.

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway. L-Citrulline is also obtained during the degradation of asymmetric dimethylarginine (ADMA), the process catalyzed by dimethylarginine dimethylaminohydrolase (DDAH), yielding dimethylamine (DMA) as a coproduct[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    L-Citrulline Related Antibodies
    Clinical Trial
    Molecular Weight

    175.19

    Formula

    C6H13N3O3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    N[C@@H](CCCNC(N)=O)C(O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 50 mg/mL (285.40 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.7081 mL 28.5404 mL 57.0809 mL
    5 mM 1.1416 mL 5.7081 mL 11.4162 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    Concentration (final)

    C2

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    Volume (final)

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (570.81 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.96%

    SDS (393 KB)

    COA (243 KB) HNMR (129 KB) RP-HPLC (240 KB) MS (68 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 5.7081 mL 28.5404 mL 57.0809 mL 142.7022 mL
    5 mM 1.1416 mL 5.7081 mL 11.4162 mL 28.5404 mL
    10 mM 0.5708 mL 2.8540 mL 5.7081 mL 14.2702 mL
    15 mM 0.3805 mL 1.9027 mL 3.8054 mL 9.5135 mL
    20 mM 0.2854 mL 1.4270 mL 2.8540 mL 7.1351 mL
    25 mM 0.2283 mL 1.1416 mL 2.2832 mL 5.7081 mL
    30 mM 0.1903 mL 0.9513 mL 1.9027 mL 4.7567 mL
    40 mM 0.1427 mL 0.7135 mL 1.4270 mL 3.5676 mL
    50 mM 0.1142 mL 0.5708 mL 1.1416 mL 2.8540 mL
    60 mM 0.0951 mL 0.4757 mL 0.9513 mL 2.3784 mL
    80 mM 0.0714 mL 0.3568 mL 0.7135 mL 1.7838 mL
    100 mM 0.0571 mL 0.2854 mL 0.5708 mL 1.4270 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    L-Citrulline Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-Citrulline372-75-8Endogenous MetaboliteInhibitorinhibitorinhibit

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