L-Citrulline DL-malate
Based on 6 publication(s) in Google Scholar
L-Citrulline (DL-malate) is an organic compound commonly used as a nutritional supplement. It boosts the body's production of nitrogen oxides, improves circulation and athletic performance, and reduces muscle fatigue. In addition, L-Citrulline DL-malate also plays an important role in some industrial fields, for example, it is used in the field of agriculture to enhance plant immunity.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 70796-17-7
- Formula: C10H19N3O8
- Molecular Weight:309.27
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications Citing Use of MedChemExpress (MCE) L-Citrulline DL-malate
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- NPJ Biofilms Microbiomes. 2025 Oct 30;11(1):202. [Abstract]
- Front Immunol. 2022 Aug 5:13:918241. [Abstract]
- PLoS Biol. 2024 Jun 27;22(6):e3002672. [Abstract]
- Exp Ther Med. 2022 Aug 22;24(4):632. [Abstract]
- bioRxiv. 2024 Apr 3:2023.06.02.542933. [Abstract]
-
Cell Imaging/Staining
-
WB
-
RT-PCR
-
IHC
-
IF
All Endogenous Metabolite Isoforms
More
Biological Activity
|
Human Endogenous Metabolite |
L-Citrulline DL-malate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 70796-17-7
-
Appearance Solid
-
Molecular Weight 309.27
-
Formula C10H19N3O8
-
Color White to off-white
-
SMILES
N[C@H](C(O)=O)CCCNC(N)=O.O=C(C(CC(O)=O)O)O
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
-
Journal Impact Factor
-
Most Recent
-
Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
NPJ Biofilms Microbiomes
L-citrulline protects testicular Sertoli cell function by mitigating DNA damage via the gut-testis axis of sheep fed a high-concentrate diet. [Abstract]2025 Oct 30;11(1):202. PMID: 41168195
L-Citrulline DL-malate purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2025 Oct 30;11(1):202. [Abstract]
L-Citrulline (Citr; 5 mM; 48 h). The representative images of ROS immunofluorescence of TM4 cell line in each group. Citr, treated with Citr; Sucrose, treated with Sucrose; Sucrose +H2O2, treated with Sucrose and Citr.
L-Citrulline DL-malate purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2025 Oct 30;11(1):202. [Abstract]
L-Citrulline (Citr; 5 mM; 48 h). Western blot of γH2AX and GAPDH in each indicated group.
L-Citrulline DL-malate purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2025 Oct 30;11(1):202. [Abstract]
L-Citrulline (Citr; 5 mM; 48 h). RT-qPCR analyzing the expression of Pcna and Gtf2h5 in each indicated group (n = 3).
-
Front Immunol
DMGV Is a Rheostat of T Cell Survival and a Potential Therapeutic for Inflammatory Diseases and Cancers. [Abstract]2022 Aug 5:13:918241. PMID: 35990633 -
PLoS Biol
2024 Jun 27;22(6):e3002672. PMID: 38935621 -
Exp Ther Med
Citrulline protects against LPS‑induced acute lung injury by inhibiting ROS/NLRP3‑dependent pyroptosis and apoptosis via the Nrf2 signaling pathway. [Abstract]2022 Aug 22;24(4):632. PMID: 36160882
L-Citrulline DL-malate purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2022 Aug 22;24(4):632. [Abstract]
L-Citrulline (Cit; 1 g/kg/day; ip). Representative histological changes of lung tissue. Scale bar, 100 µm.
L-Citrulline DL-malate purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2022 Aug 22;24(4):632. [Abstract]
L-Citrulline (Cit; 1 g/kg/day; ip). Representative macrophage infiltration shown as F4/80-positive cells. Sections were stained with primary antibodies against F4/80 (red), while the nucleus was stained with DAPI (blue). Scale bar, 100 µm. LPS, lipopolysaccharide; Con, control; Cit, citrulline.
-
bioRxiv
An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence in C. elegans. [Abstract]2024 Apr 3:2023.06.02.542933. PMID: 37333363
Solvent & Solubility
H2O : 175 mg/mL (565.85 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (249 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.2334 mL | 16.1671 mL | 32.3342 mL | 80.8355 mL |
| 5 mM | 0.6467 mL | 3.2334 mL | 6.4668 mL | 16.1671 mL | |
| 10 mM | 0.3233 mL | 1.6167 mL | 3.2334 mL | 8.0836 mL | |
| 15 mM | 0.2156 mL | 1.0778 mL | 2.1556 mL | 5.3890 mL | |
| 20 mM | 0.1617 mL | 0.8084 mL | 1.6167 mL | 4.0418 mL | |
| 25 mM | 0.1293 mL | 0.6467 mL | 1.2934 mL | 3.2334 mL | |
| 30 mM | 0.1078 mL | 0.5389 mL | 1.0778 mL | 2.6945 mL | |
| 40 mM | 0.0808 mL | 0.4042 mL | 0.8084 mL | 2.0209 mL | |
| 50 mM | 0.0647 mL | 0.3233 mL | 0.6467 mL | 1.6167 mL | |
| 60 mM | 0.0539 mL | 0.2695 mL | 0.5389 mL | 1.3473 mL | |
| 80 mM | 0.0404 mL | 0.2021 mL | 0.4042 mL | 1.0104 mL | |
| 100 mM | 0.0323 mL | 0.1617 mL | 0.3233 mL | 0.8084 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.