2. Cytoskeleton NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Dynamin Reactive Oxygen Species (ROS)
  4. L-Citrulline (GMP)

L-Citrulline GMP is an orally active, blood-brain barrier permeable neutral α-amino acid. L-Citrulline GMP inhibits the mitochondrial translocation of Drp1 and maintains mitochondrial homeostasis via a NO-dependent pathway, thereby reducing excessive ROS production. Consequently, L-Citrulline GMP protects sperm DNA integrity, stabilizes the blood-testis barrier and improves semen quality. L-Citrulline GMP can be used in research related to male infertility, mycobacterial infection (tuberculosis) and radiation combined injury.

For research use only. We do not sell to patients.

L-Citrulline (GMP)

L-Citrulline (GMP) Chemical Structure

CAS No. : 372-75-8

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L-Citrulline (GMP) Related Antibodies

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Description

L-Citrulline GMP is an orally active, blood-brain barrier permeable neutral α-amino acid. L-Citrulline GMP inhibits the mitochondrial translocation of Drp1 and maintains mitochondrial homeostasis via a NO-dependent pathway, thereby reducing excessive ROS production. Consequently, L-Citrulline GMP protects sperm DNA integrity, stabilizes the blood-testis barrier and improves semen quality. L-Citrulline GMP can be used in research related to male infertility, mycobacterial infection (tuberculosis) and radiation combined injury[1][2][3].

In Vitro

L-Citrulline (GMP) (1-2 mM) protects mouse C2C12 myoblasts against 43 °C heat stress-induced mitochondrial dysfunction and cell injury via a nitric oxide-mediated inhibition of DRP1 activation[1].
L-Citrulline GMP maintains normal autophagic flux in primary human airway epithelial cells by mitigating asymmetric dimethylarginine-induced nitrative stress via restored nitric oxide bioavailability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Citrulline (GMP) Related Antibodies
In Vivo

L-Citrulline GMP (1 g/kg; p.o.; once daily; 21 days post-irradiation) significantly accelerates skin wound healing in a mouse model of radiation combined injury, improves bone marrow clonogenicity, and produces a non-significant trend toward increased 30-day survival (40% survival rate)[3].
L-Citrulline GMP (1 g/kg; p.o.; once daily; 21 days post-irradiation), in combination with PEG-G-CSF, significantly increases 30-day survival (42% survival rate) in a mouse model of radiation combined injury, accelerates body weight recovery, improves bone marrow clonogenicity, and enhances intestinal crypt recovery[3].
L-Citrulline GMP (1 g/kg; p.o.; once daily; 21 days post-irradiation) does not significantly improve 30-day survival in mice with total-body irradiation alone, but improves bone marrow clonogenicity and partially reduces irradiation-induced splenomegaly[3].
L-Citrulline GMP (1 g/kg; p.o.; once daily; 21 days post-irradiation), in combination with PEG-G-CSF, does not significantly improve 30-day survival in mice with total-body irradiation alone, but improves bone marrow clonogenicity and fully inhibits irradiation-induced splenomegaly[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B6D2F1/J (female, 14-15 weeks old, average weight 24-25 g, radiation combined injury model)[3]
Dosage: 1 g/kg
Administration: p.o.; once daily; 21 days post-irradiation
Result: Produced a non-significant trend toward enhanced 30-day survival (40% survival, median survival time 17.5 days, P=0.057 versus vehicle).
Significantly accelerated wound healing, resulting in smaller wound areas on day 14 (P=0.0436) and day 21 (P=0.0002), and higher percentage wound closure on day 14 (P=0.01) and day 21 (P<0.0001) compared to vehicle.
Significantly increased bone marrow colony-forming unit-granulocyte-monocyte (CFU-GM) counts (P=0.032) and total colony counts (CFU-Total, P=0.0491) on day 30 post-irradiation compared to vehicle.
Increased serum citrulline levels to a moderate degree (not statistically significant versus vehicle).\nSignificantly increased 30-day survival to 42% (median survival time 18 days, P=0.007 versus vehicle), and delayed onset of death to after day 13 post-irradiation (versus 6-10 days for other treatments).
Significantly increased body weight on day 21 post-irradiation (P=0.0071 versus vehicle).
Significantly increased bone marrow CFU-GM (P<0.0001), CFU-granulocyte-erythrocyte-monocyte-megakaryocyte (CFU-GEMM, P=0.0476), and CFU-Total (P=0.0029) counts on day 30 post-irradiation compared to vehicle.
Significantly increased serum citrulline levels (P=0.0388 versus vehicle), increased jejunal crypt depth (P=0.0277 versus vehicle), and restored jejunal crypt counts to levels comparable to sham-irradiated mice on day 30 post-irradiation.
Animal Model: B6D2F1/J (female, 14-15 weeks old, average weight 24-25 g, acute radiation syndrome model)[3]
Dosage: 1 g/kg
Administration: p.o.; once daily; 21 days post-irradiation
Result: Resulted in 35% 30-day survival (median survival time 20 days), which was not significantly different from vehicle control (P=0.45).
Improved bone marrow cellularity and significantly increased bone marrow CFU-GM counts (P=0.0169) on day 30 post-irradiation compared to vehicle.
Partially inhibited irradiation-induced splenomegaly and reduced splenocyte counts in surviving mice.\nResulted in 50% 30-day survival (median survival time 26 days), which was not significantly different from vehicle control (P=0.19).
Significantly increased bone marrow CFU-GM counts (P=0.0207) on day 30 post-irradiation compared to vehicle.
Fully inhibited irradiation-induced splenomegaly and reduced splenocyte counts in surviving mice.
Molecular Weight

175.19

Formula

C6H13N3O3
CAS No.
SMILES

N[C@@H](CCCNC(N)=O)C(O)=O
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L-Citrulline (GMP) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Citrulline (GMP)372-75-8DynaminReactive Oxygen Species (ROS)mouse C2C12 myoblastsradiation combined injurynitric oxidemale infertilityTrp53caspase-3/7CD4+ T cellmycobacterial infectionDrp1primary human airway epithelial cellsInhibitorinhibitorinhibit

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