2. Academic Validation
  3. A new class of anti-HIV agents: synthesis and activity of conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor

A new class of anti-HIV agents: synthesis and activity of conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor

  • Bioorg Med Chem Lett. 1999 Mar 22;9(6):803-6. doi: 10.1016/s0960-894x(99)00089-x.
T Kimura 1,  H Matsumoto,  T Matsuda,  T Hamawaki,  K Akaji,  Y Kiso
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Japan.
PMID: 10206539 DOI: 10.1016/s0960-894x(99)00089-x
Abstract

Conjugates of HIV Protease Inhibitors with a Reverse Transcriptase Inhibitor were synthesized, which expressed excellent Antiviral activity compared with that of the individual components. The remarkable Antiviral activity of the conjugated compounds may be due to their penetration into the cell and later splitting into two different classes of anti-HIV agents.

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