2. Academic Validation
  3. Synthesis and evaluation of potential complement inhibitory semisynthetic analogs of oleanolic acid

Synthesis and evaluation of potential complement inhibitory semisynthetic analogs of oleanolic acid

  • Bioorg Med Chem Lett. 1999 Jul 19;9(14):1889-94. doi: 10.1016/s0960-894x(99)00314-5.
H Assefa 1,  A Nimrod,  L Walker,  R Sindelar
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University 38677, USA.
PMID: 10450948 DOI: 10.1016/s0960-894x(99)00314-5
Abstract

A number of semisynthetic analogs of oleanolic acid have been synthesized and tested for their complement inhibitory, cytotoxic and apoptotic activities. Among these, compounds 10 and 17 exhibited complement inhibitory potency superior to oleanolic acid. Both have also shown a moderate improvement in in vitro therapeutic index (T.I.).

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