2. Academic Validation
  3. Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors

Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors

  • J Med Chem. 2001 Dec 20;44(26):4497-500. doi: 10.1021/jm010451+.
Y T Chang 1,  S M Wignall,  G R Rosania,  N S Gray,  S R Hanson,  A I Su,  J Merlie Jr,  H S Moon,  S B Sangankar,  O Perez,  R Heald,  P G Schultz
Affiliations

Affiliation

  • 1 Department of Chemistry, New York University, 100 Washington Square East, New York, New York 10003, USA. [email protected]
PMID: 11741468 DOI: 10.1021/jm010451+
Abstract

Myoseverin, a trisubstituted purine, inhibits microtubule assembly in vitro, interferes with normal mitotic spindle assembly, and arrests the cell cycle in Mitosis in U937 cells. We synthesized a variety of myoseverin derivatives and screened them for inhibition of spindle assembly in Xenopus egg extracts and for microtubule disassembly in vitro. Selected compounds were tested against 60 Cancer cell lines at the National Cancer Institute as possible Anticancer drug candidates.

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