2. Academic Validation
  3. Alzheimer's disease is a synaptic failure

Alzheimer's disease is a synaptic failure

  • Science. 2002 Oct 25;298(5594):789-91. doi: 10.1126/science.1074069.
Dennis J Selkoe 1
Affiliations

Affiliation

  • 1 Center for Neurologic Diseases, Brigham and Women's Hospital, and the Harvard Center for Neurodegeneration and Repair, Boston, MA 02115, USA. [email protected]
PMID: 12399581 DOI: 10.1126/science.1074069
Abstract

In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid beta protein.

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