2. Academic Validation
  3. 3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility

3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility

  • Bioorg Med Chem Lett. 2003 Mar 24;13(6):1195-8. doi: 10.1016/s0960-894x(03)00046-5.
W Cameron Black 1,  Christine Brideau,  Chi Chung Chan,  Stella Charleson,  Wanda Cromlish,  Robert Gordon,  Erich L Grimm,  Gregory Hughes,  Serge Leger,  Chun Sing Li,  Denis Riendeau,  Michel Thérien,  Zhaoyin Wang,  Li Jing Xu,  Petpiboon Prasit
Affiliations

Affiliation

  • 1 Merck Frosst Centre for Therapeutic Research, PO Box 1005, Pointe-Claire-Dorval, Quebec, Canada H9R 4P8. [email protected]
PMID: 12643942 DOI: 10.1016/s0960-894x(03)00046-5
Abstract

The introduction of a hydroxyl group into the 5-position of the diaryl furanone system provides highly selective inhibitors of cyclooxygenase-2. These molecules can be converted into their sodium salts which are water soluble, facilitating intravenous formulation. These salts show excellent potency in rat models of pain, fever and inflammation.

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